Trinucleotide Repeat Instability is Modulated by DNA Base Lesions and DNA Base Excision Repair [PDF]
, 2016 Trinucleotide repeat (TNR) expansions are the cause of over 40 human neurodegenerative diseases, and are linked to DNA damage and base excision repair (BER). We explored the role of DNA damage and BER in modulating TNR instability through analysis of DNA
Beaver, Jill M
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Le rôle de l’aldostérone sur le remodelage structurel pulmonaire et la fonction ventriculaire droite en insuffisance cardiaque congestive [PDF]
, 2011 INTRODUCTION : L’insuffisance cardiaque congestive (ICC) induit remodelage pulmonaire et dysfonction ventriculaire droite (VD) qui contribuent de façon importante à la morbidité/mortalité.
Chabot, Andréanne
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Deoxyribose oxidation chemistry and endogenous DNA adducts [PDF]
, 2006 Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, 2006.Includes bibliographical references.Endogenous and exogenous oxidants react with cellular macromolecules to generate a variety of electrophiles that react with ...
Zhou, Xinfeng
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Studies on the biosynthesis and heterologous expression of complex secondary metabolites from streptomycetes [PDF]
, 2009 The heterologous expression of natural product biosynthetic pathways is of increasing interest in biotechnology and drug discovery. This approach enables the production of complex metabolites in more amenable host organisms and provides the basis for the
Binz, Tina Maria
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, 2016 We hypothesized that DNA damage products (5′R)-8,5′-cyclo-2′-deoxyadenosine (R-cdA) and (5′S)-8,5′-cyclo-2′-deoxyadenosine (S-cdA) may be well-suited biomarkers of risk and diagnosis for atherosclerosis.
Arkadiusz Jawien (2107438) +5 more
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Methodologies for the synthesis of novel modified nucleosides with therapeutic potential [PDF]
, 1990 1 v.This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author.
Nair, Vasu
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Molecular Analysis of Genes Involved in the Biosynthesis and Regulation of Hormaomycin, an Exceptionally Complex Bacterial Signaling Metabolite [PDF]
, 2013 Hormaomycin (HRM) is a nonribosomal peptide antibiotic isolated from Streptomyces griseoflavus W-384. It contains several unprecedented nonproteinogenic building blocks bearing chlorine, nitro or cyclopropyl moieties (Andres et al., 1989).
Cai, Xiaofeng
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Advances in Nucleic Acid Research: Exploring the Potential of Oligonucleotides for Therapeutic Applications and Biological Studies. [PDF]
Int J Mol Sci, 2023 Moccia M +6 more
europepmc +1 more source
Immunological Markers, Antioxidants and Prostaglandins in Pregnancy-Induced Hypertension [PDF]
, 1993 Pregnancy-induced hypertension (PIH) is still a major cause of obstetrical and perinatal morbidity and mortality, and no breakthrough has yet been achieved in the understanding of its pathogenesis.
Chen, Gong
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Development of transposon based tools for the investigation of virulence factors in Clostridium difficile [PDF]
, 2011 C. difficile is GI pathogen which under certain conditions colonises the colon leading CDI. During passage through the GI tract the bacterium in either vegetative or spore form encounters innate antimicrobial defence mechanisms evolved to prevent ...
McCurrie, K.L.A.
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