Results 41 to 50 of about 8,065 (103)

Effects of 2-chloro-2'-deoxyadenosine on the cell cycle in the human leukemia EHEB cell line.

, 2004
To explain why 2-chloro-2'-deoxyadenosine (CdA) is unable to block DNA synthesis and cell cycle progression, and paradoxically enhances progression from G1 into S phase in the CdA-resistant leukemia EHEB cell line, we studied its metabolism and effects ...
Bontemps, Françoise, Ferrant, Augustin, Smal, Caroline, Rosier, Jean-Claude, Van den Berghe, Georges, Cardoen, S., Van Den Neste, Eric   +6 more
core   +1 more source

2-Chloro-2′-deoxyadenosine inhibits DNA repair synthesis and potentiates UVC cytotoxicity in chronic lymphocytic leukea B lymphocytes

, 2002
2-Chloro-2′-deoxyadenosine (CdA) is a deoxyadenosine analogue which targets enzymes involved in DNA synthesis, and hence might interfere with the resynthesis step of DNA repair.
Husson, B., Rosier, J.-F., Van den Berghe, Georges, Van den Berghe, G., Rosier, JF, Cardoen, S, Bontemps, Françoise, Ferrant, Augustin, Bontemps, F., Delacauw, A, Van Den Neste, E., Cardoen, S., Delacauw, A., Van Den Neste, Eric   +13 more
core   +1 more source

2-chlorodeoxyadenosine (2-CDA) therapy in previously untreated patients with follicular stage III-IV non-Hodgkin's lymphoma. [PDF]

, 1996
PURPOSE: This phase II multi-institutional trial was designed to assess response and toxicity of 2-chlorodeoxyadenosine (2-CDA) in patients with previously untreated follicular lymphoma.
Egger, T., Hsu Schmitz, S. F., Bürki, K., Von Rohr, A., T. Cerny, Cerny, Thomas, A. Von Rohr, Bürki, K, Betticher, D C, T. Egger, B. Rufener, Egger, T, Cerny, T, Rufener, B., von Rohr, A, Zucca, E., AMBROSETTI, Achille, Betticher, D. C., S. F. Schmitz, Ambrosetti, A., Rufener, B, D. C. Betticher, K. Burki, Radford, J A; id_orcid, Radford, J. A., J. A. Radford, Schmitz, S F, Zucca, E, E. Zucca, Ambrosetti, A   +29 more
core   +1 more source

Study of the efficacy of a pronucleotide of 2-chloro-2'-deoxyadenosine in deoxycytidine kinase-deficient lymphoma cells.

, 2006
2-Chloro-2 '-deoxyadenosine (CdA, cladribine) is a nucleoside analogue (NA) used for the treatment of lymphoproliferative disorders. Phosphorylation of the drug to CdAMP by deoxycytidine kinase (dCK) and its subsequent conversion to CdATP is essential ...
Meier, C, Bontemps, Françoise, Delacauw, A, Galmarini, C, Van Den Neste, Eric, Balzarini, Jan   +5 more
core   +1 more source

High incidence of complications after 2-chloro-2'-deoxyadenosine combined with cyclophosphamide in patients with advanced lymphoproliferative malignancies.

, 2004
peer reviewedThe combination of purine analogs with alkylating agents is able to produce a synergistic antitumoral effect. However, the addition of immunosuppressive and DNA-targeting agents might increase purine analog-related complications.
André, M., Ferrant, A., Francart, J., Francart, Julie, André, Marc, Sonet, A., Michaux, L., Costantini, S., Ferrant, Augustin, Michaux, Lucienne, Lambert, Catherine, Lambert, C., LAYIOS, Nathalie, Robert, A., Van Den Neste, E., Van Den Neste, Eric, Robert, Annie, Costantini, Sabrina, Sonet, Anne   +18 more
core   +1 more source

On the bioavailability of oral and subcutaneous 2-chloro-2'-deoxyadenosine in humans: alternative routes of administration.

, 1992
PURPOSE The antimetabolite 2-chloro-2'-deoxyadenosine (CdA) is a promising alternative to alkylating agents for the treatment of lymphoproliferative disorders. Its use, however, is hampered by the need for intravenous (IV) administration.
M Hassan, G Juliusson, J Liliemark, F Albertioni   +3 more
core   +1 more source

Inhibition of the ERK pathway promotes apoptosis induced by 2-chloro-2'-deoxyadenosine in the B-cell leukemia cell line EHEB.

, 2006
2-Chloro-2'-deoxyadenosine (CdA) is a nucleoside analogue active in B-cell chronic lymphocytic leukemia (B-CLL). Although the mechanism of action of CdA has been extensively investigated in leukemic cells, the possibility that this nucleoside analogue ...
Bontemps, Françoise, Lisart, Stéphanie, Ferrant, Augustin, Smal, Caroline, Van Den Neste, Eric   +4 more
core   +1 more source

Advances in Nucleic Acid Research: Exploring the Potential of Oligonucleotides for Therapeutic Applications and Biological Studies. [PDF]

Int J Mol Sci, 2023
Moccia M, Pascucci B, Saviano M, Cerasa MT, Terzidis MA, Chatgilialoglu C, Masi A.   +6 more
europepmc   +1 more source

CDA-2 decreases pulmonary inflammation.

, 2013
Induction of inflammatory cytokine and chemokine mRNA in homogenates of 3 or 5 days 2000 mg/kg CDA-2 (A) or 800 mg/kg PG (B) treated lungs was measured by real time PCR.
Hai-Ying Wan (284027), Xuan Wang (55634), Kai-Yin Wu (284026), Robert Bals (272688), Wen-Qiang Quan (284025), Jun-Lu Wu (284024), Dong Li (212687), Cui-Min Jiang (293821)   +7 more
core   +1 more source

Potentiation of antitumor effects of cyclophosphamide derivatives in B-chronic lymphocytic leukemia cells by 2-chloro-2'-deoxyadenosine.

, 1999
Because 2-chloro-2'-deoxyadenosine (CdA) is active in B-chronic lymphocytic leukemia (B-CLL), and may interfere with DNA repair, we investigated the potentiating effect of CdA on the cytotoxicity induced in vitro in B-CLL lymphocytes by cyclophosphamide (
Cardoen, S, Bontemps, Françoise, Scheiff, Jean-Marie, Leveugle, P, Ferrant, Augustin, Delacauw, A, Van den Berghe, Georges, Gillis, E, Deneys, Véronique, Van Den Neste, Eric, Louviaux, I   +10 more
core   +1 more source