Results 41 to 50 of about 134,788,912 (103)

High levels of oxidatively generated DNA damage 8,5?-cyclo-2?-deoxyadenosine accumulate in the brain tissues of xeroderma pigmentosum group A gene-knockout mice

, 2019
Xeroderma pigmentosum (XP) is a genetic disorder associated with defects in nucleotide excision repair, a pathway that eliminates a wide variety of helix-distorting DNA lesions, including ultraviolet-induced pyrimidine dimers.
Nakane H, Chatgilialoglu C, Kaidoh T, Hasegawa M, Iwamoto T, Mori T, Tanaka K, Sugiura S, Krokidis MG   +8 more
core   +1 more source

The photochemistry of 8-bromo-2_-deoxyadenosine. A direct entry to cyclopurine lesions

, 2004
The UV photolysis of 8-bromo-2'-deoxyadenosine has been investigated in different solvents and in the presence of additives like halide anions. Photolytic cleavage of the C-Br bond leads to formation of the C8 radical.
Miguel A Miranda, Maria Luisa Navacchia, Chryssostomos Chatgilialoglu, Liliana B Jimenez, Susana Encinas   +4 more
core   +1 more source

Effects of 2-chloro-2'-deoxyadenosine on the cell cycle in the human leukemia EHEB cell line.

, 2004
To explain why 2-chloro-2'-deoxyadenosine (CdA) is unable to block DNA synthesis and cell cycle progression, and paradoxically enhances progression from G1 into S phase in the CdA-resistant leukemia EHEB cell line, we studied its metabolism and effects ...
Bontemps, Françoise, Ferrant, Augustin, Smal, Caroline, Rosier, Jean-Claude, Van den Berghe, Georges, Cardoen, S., Van Den Neste, Eric   +6 more
core   +1 more source

8-amino(2-aminoethyl)-2′-deoxyadenosine incorporation into DNA by solid phase synthesis

, 1993
Solid phase synthesis of modified oligonucleotide 5 containing 8-amino(2-aminoethyl)-2'-deoxyadenosine unit is reported using trifluoroacetyl as a C8-side chain amino protector.
Parkash, T. P., Ganesh, K. N., T.P. Parkash, K.N. Ganesh   +3 more
core   +1 more source

Mutagenicity and Genotoxicity of (5′S)‑8,5′-Cyclo-2′-deoxyadenosine in Escherichia coli and Replication of (5′S)‑8,5′-Cyclopurine-2′-deoxynucleosides in Vitro by DNA Polymerase IV, Exo-Free Klenow Fragment, and Dpo4

, 2015
Reactive oxygen species generate many lesions in DNA, including R and S diastereomers of 8,5′-cyclo-2′-deoxyadenosine (cdA) and 8,5′-cyclo-2′-deoxyguanosine (cdG).
Ashis K. Basu (630373), Varsha Pednekar (1308057), Savithri Weerasooriya (630371), Vijay P. Jasti (630372)   +3 more
core   +1 more source

Elevated urinary levels of 8-oxo-2 '-deoxyguanosine, (5 ' R)- and (5 ' S)-8,5 '-cyclo-2 '-deoxyadenosines, and 8-iso-prostaglandi F-2 alpha as potential biomarkers of oxidative stress in patients with prediabetes

, 2016
Prediabetes is the preclinical stage of type 2 diabetes mellitus (T2DM) with intermediate state of hyperglycemia. Hyperglycemia results in a state of oxidative stress, which may contribute to the production of insulin resistance, beta-cell dysfunction ...
İŞLEKEL, GÜL HÜRAY, Kant, Melis, Akis, Merve, BAYRAKTAR, FIRAT, Calan, Mehmet, Arkan, Tugba, Dizdaroglu, Miral   +6 more
core   +1 more source

2-Chloro-2′-deoxyadenosine inhibits DNA repair synthesis and potentiates UVC cytotoxicity in chronic lymphocytic leukea B lymphocytes

, 2002
2-Chloro-2′-deoxyadenosine (CdA) is a deoxyadenosine analogue which targets enzymes involved in DNA synthesis, and hence might interfere with the resynthesis step of DNA repair.
Husson, B., Rosier, J.-F., Van den Berghe, Georges, Van den Berghe, G., Rosier, JF, Cardoen, S, Bontemps, Françoise, Ferrant, Augustin, Bontemps, F., Delacauw, A, Van Den Neste, E., Cardoen, S., Delacauw, A., Van Den Neste, Eric   +13 more
core   +1 more source

Radical-induced purine lesion formation is dependent on DNA helical topology

, 2016
Herein we report the quantification of purine lesions arising from gamma-radiation sourced hydroxyl radicals (HO(•)) on tertiary dsDNA helical forms of supercoiled (SC), open circular (OC) and linear (L) conformation, along with single-stranded folded ...
Chatgilialoglu, Chryssostomos, Krokidis, Marios, Molphy, Zara, Terzidis, Michael, Kellett, Andrew, Prisecaru, Andreea, Dumont, Elise, Terzidis, Michael A, RANDAZZO, ANTONIO, Krokidis, Marios G, Barron, Niall, Randazzo Antonio, Terzidis Michael A, Molphy Zara, Krokidis Marios G, Barron Niall, Kellett Andrew, Chatgilialoglu Chryssostomos, Prisecaru Andreea, Dumont Elise   +19 more
core   +1 more source

Pharmacological inhibition of the MAPK/ERK pathway increases sensitivity to 2-chloro-2'-deoxyadenosine (CdA) in the B-cell leukemia cell line EHEB.

, 2007
EHEB leukemic cells, which are derived from a patient suffering B-cell chronic lymphocytic leukemia (B-CLL), display intermediate sensitivity to the purine analogue 2-chloro-2'-deoxyadenosine (CdA).
Bontemps, Françoise, Lisart, Stéphanie, Ferrant, Augustin, Smal, Caroline, Van Den Neste, Eric, Maerevoet, Marie   +5 more
core   +1 more source

Oligodeoxynucleotides Containing N1-Methyl-2′-Deoxyadenosine and N6-Methyl-2′-Deoxyadenosine

, 2009
This unit describes a simple and efficient synthesis of the phosphoramidite derivative of N(1)-methyl-2'-deoxyadenosine from 2'-deoxyadenosine. The synthesis starts with the monomethoxytritylation of 2'-deoxyadenosine followed by methylation of 5'-O ...
Herdewijn, Piet, Timofeev, Edward, Roesch, Eric, Drenichev, Mikhail, Lemaitre, Marc, Mikhailov, Sergey, Efimtseva, Ekaterina   +6 more
core   +1 more source