Results 51 to 60 of about 8,065 (103)

Radical-induced purine lesion formation is dependent on DNA helical topology

, 2016
Herein we report the quantification of purine lesions arising from gamma-radiation sourced hydroxyl radicals (HO(•)) on tertiary dsDNA helical forms of supercoiled (SC), open circular (OC) and linear (L) conformation, along with single-stranded folded ...
Chatgilialoglu, Chryssostomos, Krokidis, Marios, Molphy, Zara, Terzidis, Michael, Kellett, Andrew, Prisecaru, Andreea, Dumont, Elise, Terzidis, Michael A, RANDAZZO, ANTONIO, Krokidis, Marios G, Barron, Niall   +10 more
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Chemistry and Biology of 8,5\u27-Cyclo-2\u27-deoxyguanosine and Other DNA Lesions

, 2013
8,5’-Cyclopurine deoxynucleosides are unique tandem lesions containing an additional covalent bond between the base and the sugar. These mutagenic and genotoxic lesions are repaired only by nucleotide excision repair (NER). It was shown that the R-cdA is
Das, Rajat S
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Long-lasting complete remission in patients with hairy cell leukemia trated with 2-CdA: a 5-year survey

, 1997
Between January 1991 and January 1994, 40 patients with hairy-cell leukemia (HCL), 30 males and 10 females, with a median age of 54 years, were treated with a single course of 2-chlorodeoxyadenosine (2-CdA) at a dose of 0.1 mg/kg/day continuous infusion ...
RONDELLI D., LAURIA F., RASPADORI D., VENTURA M. A., BIRTOLO S., BOCCHIA M., TURA S., ZINZANI P. L., FORCONI F., SALVUCCI M., MAROTTA G.   +10 more
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Resistance to 2-chloro-2'-deoxyadenosine of the human B-cell leukemia cell line EHEB.

, 2001
The effects of 2-chloro-2'-deoxyadenosine (CdA, cladribine), an adenosine deaminase-resistant analogue toxic for both proliferating and resting lymphoid cells, were investigated in the human leukemia cell line EHEB, which was derived from a patient with ...
Delacauw, Anne, Rosier, Jean-François, Bontemps, Françoise, Ferrant, Augustin, Smal, Caroline, Cardoen, Sabine, Van den Berghe, Georges, Van Den Neste, Eric   +7 more
core  

Abstract 3943: Oxidatively induced DNA base damage in non-small cell lung cancer

, 2010
Non-small cell lung cancer (NSCLC) accounts for 80-85% of all cases of lung cancer and is known to be caused by smoking and other carcinogenic agents. Oxidatively induced DNA damage is involved in multiple modifications and mutations in DNA, thereby in ...
Miral Dizdaroglu, Sanli, Aydin, Guldal Kirkali, Aydin Sanli, Resmi, Halil, Onen, Ahmet, Dizdaroglu, Miral, Ozlem Senol, Senol, Ozlem, Ahmet Onen, Can Sevinc, Kirkali, Guldal, Halil Resmi, SEVİNÇ, CAN, Taylan, Ebru, Ebru Taylan   +15 more
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2-CDA-Treatment on eight patients suffering from hairy cell leukemia [PDF]

, 2007
Acht an Haarzell-Leukämie erkrankte Patienten wurden zwischen September 1993 und November 1997 mit 2-CDA in einer Dosierung von 0,9 mg/kg Körpergewicht behandelt. Vor dieser Therapie bestanden die häufigsten Erstsymptome in Müdigkeit (7/8), Nachtschweiß (
Grömmer, Angela
core  

Assessing the Formation of Purine Lesions in Mitochondrial DNA of Cockayne Syndrome Cells. [PDF]

Biomolecules, 2022
Chatgilialoglu C, Krokidis MG, Masi A, Barata-Vallejo S, Ferreri C, Pascucci B, D'Errico M.   +6 more
europepmc   +1 more source

Randomised Introduction of 2-CDA as Intensification during Consolidation for Children with High-risk AML--results from Study AML-BFM 2004

, 2015
BACKGROUND The outcome in children and adolescents with high-risk (HR) acute myeloid leukemia (AML) is still unsatisfactory. Therefore, in study AML-BFM 2004 we aimed to improve outcome of HR-patients by adding moderately dosed 2-Chloro-2-Deoxyadenosine
Bourquin, J-P, Reinhardt, D, Graf, N, Stray, J, Lehrnbecher, T, Kremens, B, von Neuhoff, C, Klingebiel, T, Creutzig, U, Zimmermann, M, Gruhn, B, Fleischhack, G, Dworzak, M, von Stackelberg, A   +13 more
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Apoyo técnico del CDA para la elaboración del diagnostico del estado actual del botadero a cielo abierto, sistema de acueducto y alcantarillado del municipio de Barrancominas

, 2021
Apoyar la oficina seccional Guainía de la Corporación para el desarrollo sostenible del norte y el oriente amazónico CDA en el diagnóstico técnico de la situación actual del botadero a cielo abierto, sistema de acueducto y alcantarillado, teniendo en ...
Montoya Lesmes, Ingrid Lizeth
core  

2-chloro-deoxyadenosine induces durable complete remission in Castleman's disease but may accelerate its transformation to non-Hodgkin's lymphoma

, 2003
There is currently no consensus on the best treatment for unresectable hyaline-vascular variant or for multicentric Castleman's disease (MCD), because none of the reported regimens have consistently produced complete response or durable remission in the ...
Yunis, Melissa Palis [UNIFESP], Souza, Vanda Akiko Ueda Fick de, Duarte, Luiz Cláudio de Carvalho [UNIFESP], Veras, Marcos Serra de Lobão [UNIFESP], Colleoni, Gisele Wally Braga [UNIFESP], Bordin, Jose Orlando [UNIFESP], Kerbauy, Fábio Rodrigues [UNIFESP], Oliveira, José Salvador Rodrigues de [UNIFESP], Alves, Antonio Correa [UNIFESP]   +8 more
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