Results 51 to 60 of about 134,788,912 (103)

Metabolism and cytotoxic effects of 2-chloroadenine, the major catabolite of 2-chloro-2'-deoxyadenosine.

, 2000
EHEB cells, a continuous cell line derived from a patient with B cell chronic lymphocytic leukemia (B-CLL), synthesized, when incubated with tritiated 2-chloro-2'-deoxyadenosine (CdA), labeled mono-, di-, and triphosphate ribonucleosides at a much higher
Cardoen, S, Bontemps, Françoise, Delacauw, A, Van den Berghe, Georges, Van Den Neste, Eric, Georges Van Den Berghe, Eric Van Den Neste, Sabine Cardoen, Françoise Bontemps, Anne Delacauw   +9 more
core   +1 more source

Advances in Nucleic Acid Research: Exploring the Potential of Oligonucleotides for Therapeutic Applications and Biological Studies. [PDF]

Int J Mol Sci, 2023
Moccia M, Pascucci B, Saviano M, Cerasa MT, Terzidis MA, Chatgilialoglu C, Masi A.   +6 more
europepmc   +1 more source

Abstract 3943: Oxidatively induced DNA base damage in non-small cell lung cancer

, 2010
Non-small cell lung cancer (NSCLC) accounts for 80-85% of all cases of lung cancer and is known to be caused by smoking and other carcinogenic agents. Oxidatively induced DNA damage is involved in multiple modifications and mutations in DNA, thereby in ...
Miral Dizdaroglu, Sanli, Aydin, Guldal Kirkali, Aydin Sanli, Resmi, Halil, Onen, Ahmet, Dizdaroglu, Miral, Ozlem Senol, Senol, Ozlem, Ahmet Onen, Can Sevinc, Kirkali, Guldal, Halil Resmi, SEVİNÇ, CAN, Taylan, Ebru, Ebru Taylan   +15 more
core   +1 more source

2-chloro-2'-deoxyadenosine: Clinical applications in hematology

, 1996
The anticancer drug 2-chloro-2'-deoxyadenosine (CdA) belongs to the family of purine nucleoside analogs. CdA is exquisitely cytotoxic both to the dividing and to the non-dividing lymphocyte, which supports its use in lymphoproliferative disorders of low ...
Delannoy, André
core   +1 more source

Study of the efficacy of a pronucleotide of 2-chloro-2'-deoxyadenosine in deoxycytidine kinase-deficient lymphoma cells.

, 2006
2-Chloro-2 '-deoxyadenosine (CdA, cladribine) is a nucleoside analogue (NA) used for the treatment of lymphoproliferative disorders. Phosphorylation of the drug to CdAMP by deoxycytidine kinase (dCK) and its subsequent conversion to CdATP is essential ...
Meier, C, Bontemps, Françoise, Delacauw, A, Galmarini, C, Van Den Neste, Eric, Balzarini, Jan   +5 more
core   +1 more source

Inhibition of the ERK pathway promotes apoptosis induced by 2-chloro-2'-deoxyadenosine in the B-cell leukemia cell line EHEB.

, 2006
2-Chloro-2'-deoxyadenosine (CdA) is a nucleoside analogue active in B-cell chronic lymphocytic leukemia (B-CLL). Although the mechanism of action of CdA has been extensively investigated in leukemic cells, the possibility that this nucleoside analogue ...
Bontemps, Françoise, Lisart, Stéphanie, Ferrant, Augustin, Smal, Caroline, Van Den Neste, Eric   +4 more
core   +1 more source

On the bioavailability of oral and subcutaneous 2-chloro-2'-deoxyadenosine in humans: alternative routes of administration.

, 1992
PURPOSE The antimetabolite 2-chloro-2'-deoxyadenosine (CdA) is a promising alternative to alkylating agents for the treatment of lymphoproliferative disorders. Its use, however, is hampered by the need for intravenous (IV) administration.
M Hassan, G Juliusson, J Liliemark, F Albertioni   +3 more
core   +1 more source

Assessing the Formation of Purine Lesions in Mitochondrial DNA of Cockayne Syndrome Cells. [PDF]

Biomolecules, 2022
Chatgilialoglu C, Krokidis MG, Masi A, Barata-Vallejo S, Ferreri C, Pascucci B, D'Errico M.   +6 more
europepmc   +1 more source

Potentiation of antitumor effects of cyclophosphamide derivatives in B-chronic lymphocytic leukemia cells by 2-chloro-2'-deoxyadenosine.

, 1999
Because 2-chloro-2'-deoxyadenosine (CdA) is active in B-chronic lymphocytic leukemia (B-CLL), and may interfere with DNA repair, we investigated the potentiating effect of CdA on the cytotoxicity induced in vitro in B-CLL lymphocytes by cyclophosphamide (
Cardoen, S, Bontemps, Françoise, Scheiff, Jean-Marie, Leveugle, P, Ferrant, Augustin, Delacauw, A, Van den Berghe, Georges, Gillis, E, Deneys, Véronique, Van Den Neste, Eric, Louviaux, I   +10 more
core   +1 more source

Chemistry and Biology of 8,5\u27-Cyclo-2\u27-deoxyguanosine and Other DNA Lesions

, 2013
8,5’-Cyclopurine deoxynucleosides are unique tandem lesions containing an additional covalent bond between the base and the sugar. These mutagenic and genotoxic lesions are repaired only by nucleotide excision repair (NER). It was shown that the R-cdA is
Das, Rajat S
core   +1 more source