Biomimetic Radical Chemistry and Applications [PDF]
, 2020 The enormous importance of free radical chemistry for a variety of biological events, including ageing and inflammation, has attracted a strong interest in understanding the related mechanistic steps at the molecular level.
Chatgilialoglu, Chryssostomos
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Biomarkers Signal Contaminant Effects on the Organs of English Sole (Parophrys vetulus) from Puget Sound [PDF]
, 2006 Fish living in contaminated environments accumulate toxic chemicals in their tissues. Biomarkers are needed to identify the resulting health effects, particularly focusing on early changes at a subcellular level.
Beer +98 more
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The influence of 2- chlorodeoxyadenosine in combination with tumour necrosis factor-α or its mutein on murine leukaemias L1210 and P388 [PDF]
, 1995 We investigated the influence of 2-chlorodeoxyadenosine (2-CdA) in combination with tumour necrosis factor-α (TNFα) or its mutein VI, which differs from the native molecule by N-terminal amino acid composition, on the survival time of mice inoculated ...
Góra-Tybor, J., Robak, T., Warzocha, K.
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Active transcriptomic and proteomic reprogramming in the C-elegans nucleotide excision repair mutant xpa-1 [PDF]
, 2013 Peer ...
Arczewska, Katarzyna D. +16 more
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DNA Damage, Oxidative Stress and Related Metabolic By-Products in Cancer and Environmental Studies [PDF]
, 2022 Computational fluid dynamics (CFD), which uses numerical analysis to predict and model complex flow behaviors and transport processes, has become a mainstream tool in engineering process research and development.
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Novel Antitumoral Strategies Inducing Membrane Lipid and DNA Damage:Artificial Chemical Nucleases & the ‘ClickGene’ Project [PDF]
, 2019 This PhD project was carried out within the frame of a Marie Curie Network with the acronym ‘ClickGene’, which focuses on the development of next-generation gene silencing therapeutics, such as the artificial metallo-nucleases (AMNs).
Menounou, Georgia <1991>
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Chemistry meets biology in colitis-associated carcinogenesis [PDF]
, 2013 The intestine comprises an exceptional venue for a dynamic and complex interplay of numerous chemical and biological processes. Here, multiple chemical and biological systems, including the intestinal tissue itself, its associated immune system, the gut ...
Dedon, Peter C. +4 more
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Mutagenesis and Genetic Control of Translesion Synthesis Across an Abasic Site, 8,5’-Cyclopurines and \u3cem\u3eO\u3c/em\u3e\u3csup\u3e2\u3c/sup\u3e-Alkylthymidine DNA Lesions [PDF]
, 2015 DNA contains the genetic information of all living organisms. Therefore, its integrity and stability are essential for the long-term viability of the organism.
Weerasooriya, Savithri Anurada Kumari
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Epigenetic Instability Induced by DNA Base Lesion via DNA Base Excision Repair [PDF]
, 2017 DNA damage can cause genome instability, which may lead to human cancer. The most common form of DNA damage is DNA base damage, which is efficiently repaired by DNA base excision repair (BER).
Jiang, Zhongliang
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Oxidative DNA Damage Modulates Trinucleotide Repeat Instability Via DNA Base Excision Repair [PDF]
, 2014 Trinucleotide repeat (TNR) expansion is the cause of more than 40 types of human neurodegenerative diseases such as Huntington’s disease. Recent studies have linked TNR expansion with oxidative DNA damage and base excision repair (BER). In this research,
Xu, Meng
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