The Influence of 5′,8-Cyclo-2′-Deoxyguanosine on ds-DNA Charge Transfer Depends on Its Diastereomeric Form: A Theoretical Study [PDF]
Antioxidants, 2023 The genetic information stored in the nucleobase sequence is continuously exposed to harmful extra- and intra-cellular factors, which can lead to different types of DNA damage, with more than 70 lesion types identified so far.
Bolesław T. Karwowski
doaj +4 more sources
When UDG and hAPE1 Meet Cyclopurines. How (5′R) and (5′S) 5′,8-Cyclo-2′-deoxyadenosine and 5′,8-Cyclo-2′-deoxyguanosine Affect UDG and hAPE1 Activity? [PDF]
Molecules, 2021 Ionizing radiation is a factor that seriously damages cellular mechanisms/macromolecules, e.g., by inducing damage in the human genome, such as 5′,8-cyclo-2′-deoxypurines (cdPus).
Michał Szewczuk +3 more
doaj +5 more sources
How (5′S) and (5′R) 5′,8-Cyclo-2′-Deoxypurines Affect Base Excision Repair of Clustered DNA Damage in Nuclear Extracts of xrs5 Cells? A Biochemical Study [PDF]
Cells, 2021 The clustered DNA lesions (CDLs) are a characteristic feature of ionizing radiation’s impact on the human genetic material. CDLs impair the efficiency of cellular repair machinery, especially base excision repair (BER).
Karolina Boguszewska +3 more
doaj +6 more sources
Effects of Aging and Disease Conditions in Brain of Tumor-Bearing Mice: Evaluation of Purine DNA Damages and Fatty Acid Pool Changes [PDF]
Biomolecules, 2022 The consequences of aging and disease conditions in tissues involve reactive oxygen species (ROS) and related molecular alterations of different cellular compartments.
Marios G. Krokidis +5 more
doaj +5 more sources
The Influence of 5′R and 5′S cdA and cdG on the Activity of BsmAI and SspI Restriction Enzymes [PDF]
Molecules, 2021 Restriction endonucleases (REs) are intra-bacterial scissors that are considered tools in the fight against foreign genetic material. SspI and BsmAI, examined in this study, cleave dsDNA at their site of recognition or within a short distance of it. Both
Michał Szewczuk +3 more
doaj +6 more sources
The association constant of 5',8-cyclo-2'-deoxyguanosine with cytidine [PDF]
Frontiers in Chemistry, 2015 The association of 5',8-cyclo-2'-deoxyguanosine (cdG), a DNA tandem lesion, with its complementary base cytosine has been studied by voltammetry and NMR in chloroform, using properly silylated derivatives of the two nucleobases for increasing their ...
Amedeo eCapobianco +7 more
doaj +6 more sources
An ameliorative protocol for the quantification of purine 5',8-cyclo-2'-deoxynucleosides in oxidized DNA [PDF]
Frontiers in Chemistry, 2015 5',8-Cyclo-2'-deoxyadenosine (cdA) and 5',8-cyclo-2'-deoxyguanosine (cdG) are lesions resulting from hydroxyl radical (HO•) attack on the 5'H of the nucleoside sugar moiety and exist in both 5'R and 5'S diastereomeric forms.
Michael A. Terzidis +2 more
doaj +5 more sources
Radiation-induced formation of purine lesions in single and double stranded DNA: Revised quantification [PDF]
Frontiers in Chemistry, 2015 The formation of oxidative lesions arising from double stranded DNA damage is of major significance to chemical biology from the perspective of application to human health.
Michael A. Terzidis +3 more
doaj +5 more sources
The Influence of 5′,8-Cyclo-2′-deoxypurines on the Mitochondrial Repair of Clustered DNA Damage in Xrs5 Cells: The Preliminary Study [PDF]
Molecules, 2021 The 5′,8-cyclo-2′-deoxypurines (cdPus) affect the DNA structure. When these bulky structures are a part of clustered DNA lesions (CDL), they affect the repair of the other lesions within the cluster.
Karolina Boguszewska +2 more
doaj +2 more sources
5',8-Cyclopurine Lesions in DNA Damage: Chemical, Analytical, Biological, and Diagnostic Significance. [PDF]
Cells, 2019 Purine 5′,8-cyclo-2′-deoxynucleosides (cPu) are tandem-type lesions observed among the DNA purine modifications and identified in mammalian cellular DNA in vivo.
Chatgilialoglu C +8 more
europepmc +2 more sources