Results 111 to 120 of about 12,458,805 (285)

Effects of 5-Fluorouracil on the Expression of Epigenetic Enzymes and Promoter Methylation of Selected Genes in Monolayer and Spheroid Cultures of Colorectal Cancer Cells [PDF]

Pharmaceutical Sciences
Background: Emerging evidence suggests that epigenetic mechanisms contribute to 5-fluorouracil (5-FU) resistance in colorectal cancer (CRC). However, there is limited research on the direct impact of 5-FU on epigenetic alterations in CRC.
Maryam Niknam, Masoumeh Varedi, Mozhdeh Zamani, Pooneh Mokarram, Fakhraddin Naghibalhossaini   +4 more
doaj   +1 more source

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida, Gisela Cristiane Miyamoto, Daniel da Costa Torres, Ian Setubal Reis Chaves, Jonas do Carmo Paschoalin, Braúlio Lima Nascimento, Luciana Dias Chiavegato   +6 more
wiley   +1 more source

Effect of BCL2A1 overexpression on 5-FU-resistance in MDA-MB-231 and T-47D.

, 2016
BCL2A1 protein expression of (A) MDA-MB-231 and (C) T-47D after transfection with a pCMV-Myc-DDK Entry vector (Vector) or a pCMV-Myc-DDK BCL2A1 vector (BCL2A1).
Minoru Narita (124368), Katsuhide Igarashi (589096), Yoshinori Kato (513791), Maky Otsuka (3207804), Takeshi Karasawa (3207801), Naoko Kuzumaki (124344), Atsunobu Sagara (277962), Noriko Gotoh (133877), Michiko Narita (124347)   +8 more
core   +1 more source

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

Comparison of IC₅₀ of GC/5-FU, CS/5-FU and 5-FU for SW480 and SMMC-7721 cells (n = 3).

, 2013
Comparison of IC50 of GC/5-FU, CS/5-FU and 5-FU for SW480 and SMMC-7721 cells (n = 3).
Tao Wan (302796), Bing He (135034), Bingbing Zha (118060), Jiang Han (302799), Tao Ye (302804), Qing Li (84975), Wei Wang (17594), Hongzhi Xu (302803), Houxiang Chen (302801), Mingrong Cheng (302795), Weiping Zhu (302797), Fengxiao Yang (302802)   +11 more
core   +1 more source

Successful outcomes of pediatric dacryocystorhinostomy with adjunctive 5-fluorouracil

Frontiers in Ophthalmology
PurposeTo determine whether nasal intramucosal 5-fluorouracil (5-FU) injection improves outcomes after external dacryocystorhinostomy (DCR) in pediatric patients with nasolacrimal duct obstruction (NLDO).MethodsMulti-center retrospective non-comparative ...
Alina K. Sinha, Ethan L. Kahana, Tomas E. Meijome, Adam Jacobson, Jane Z. Spadaro, Jane Z. Spadaro, Stella Y. Chung, Stella Y. Chung, Alon Kahana, Alon Kahana   +9 more
doaj   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Parameters after the administration of 5-Fu and 5-FU-NPS in plasma of mice.

, 2014
5-FU-NP compared with 5-FU solution by T-test ...
Lei Yu (70258), Shan Muhammad (492237), Yinggang Chen (492235), Zheng Liu (28397), Zheng Jiang (282949), Qingchao Tang (492232), Rui Huang (141490), Xishan Wang (282956), Qi You (492233), Yihui Wang (572378), Guiyu Wang (492234)   +10 more
core   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Targeted Drug Delivery to Chemoresistant Cells:  Folic Acid Derivatization of FdUMP[10] Enhances Cytotoxicity toward 5-FU-Resistant Human Colorectal Tumor Cells.

, 2016
Targeted Drug Delivery to Chemoresistant Cells:  Folic Acid Derivatization of FdUMP[10] Enhances Cytotoxicity toward 5-FU-Resistant Human Colorectal Tumor ...
William H. Gmeiner (1267275), Jinqian Liu (1825714), Terrence A. Lawson (3031200), Carol Kolar (232014)   +3 more
core   +2 more sources