Results 91 to 100 of about 9,064,090 (287)
Chimeric Antigen Receptor Cell Therapy: Empowering Treatment Strategies for Solid Tumors
Current Issues in Molecular BiologyChimeric antigen receptor-T (CAR-T) cell therapy has demonstrated impressive efficacy in the treatment of blood cancers; however, its effectiveness against solid tumors has been significantly limited.
Tang-Her Jaing +2 more
doaj +1 more source
International Journal of Endocrinology, 2016 Background. The aims of this study were to analyze the clinical characteristics of SPM in patients with well-differentiated thyroid cancer and to determine the long-term prognosis in patients with double malignancies. Materials and Methods.
Miaw-Jene Liou +4 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
5-FU induced encephalopathy during 5-FU containing regimen for esophageal squamous cell carcinoma.
, 2012 138 Background: 5-FU induced encephalopathy was known as uncommon toxicity during the treatment which contain with 5-FU. But there were few reports such as clinical feature and risk factors of 5-FU induced encephalopathy.
Yoshitaka Honma +9 more
core +1 more source
, 2016 Targeted Drug Delivery to Chemoresistant Cells: Folic Acid Derivatization of FdUMP[10] Enhances Cytotoxicity toward 5-FU-Resistant Human Colorectal Tumor ...
William H. Gmeiner (1267275) +3 more
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Effect of BCL2A1 overexpression on 5-FU-resistance in MDA-MB-231 and T-47D.
, 2016 BCL2A1 protein expression of (A) MDA-MB-231 and (C) T-47D after transfection with a pCMV-Myc-DDK Entry vector (Vector) or a pCMV-Myc-DDK BCL2A1 vector (BCL2A1).
Minoru Narita (124368) +8 more
core +1 more source
Efeitos da sinvastatina na mucosite gastrointestinal induzida por 5-fluorouracil em ratos.
Revista do Colégio Brasileiro de Cirurgiões, 2018 RESUMO Objetivo: examinar os efeitos da sinvastatina na mucosite gástrica e intestinal após o tratamento com 5-fluorouracil (5-FU), determinados pela expressão de citocinas e histologia em ratos.
Aldo da Cunha Medeiros +4 more
doaj +1 more source