Results 81 to 90 of about 9,064,090 (287)
Calbindin 2 (CALB2) regulates 5-fluorouracil sensitivity in colorectal cancer by modulating the intrinsic apoptotic pathway. [PDF]
PLoS ONE, 2011 The role of the calcium binding protein, Calbindin 2 (CALB2), in regulating the response of colorectal cancer (CRC) cells to 5-Fluorouracil (5-FU) was investigated.
Leanne Stevenson +8 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
5-FU resistant CRC-PDX samples exhibit increased Rpl22L1 staining.
, 2019 A. Representative picture from a TMA constructed using CRC PDX samples reveals that RPL22L1 is highly expressed in CRC PDX samples compared with normal colon (20X magnification).
Jens Hoffmann (222702) +8 more
core +1 more source
Transdermal delivery of 5-fluorouracil (5-FU) by 1-alkylcarbonyl-5-FU prodrugs
International Journal of Pharmaceutics, 1996 The members of a series of 1-alkylcarbonyl-5-FU prodrug derivatives have been characterized and evaluated for their abilities to deliver 5-FU into and through skin. There was no correlation of lipid solubility or partition coefficient with relative abilities of the members of the 1-alkylcarbonyl series to deliver 5-FU through skin. However, there was a
Department of Medicinal Chemistry, P.O. Box 100485, University of Florida, Gainesville, FL 32610, USA ( host institution ) +2 more
openaire +2 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
LifeThis study aimed to investigate the possible histopathological and immunohistochemical effects of bovine colostrum (BC) against the toxic effects of 5-fluorouracil (5-FU) on the liver, kidney, and heart of Wistar Albino rats.
Muhammet Bahaeddin Dörtbudak +4 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
β-carotene as a novel adjuvant in the therapy with 5-FU of p53 deleted colon cancer cells
, 2021 Colon cancer is one of the leading causes of cancer-related death worldwide. The main cause of failure in colon cancer therapy is represented by drug resistance in the course of treatment which has become very common.
Giulia Russo +3 more
core
A Case of Hyperammonemia Associated with High Dihydropyrimidine Dehydrogenase Activity
Case Reports in Oncological Medicine, 2016 Over the past decades, 5-Fluorouracil (5-FU) has been widely used to treat several types of carcinoma, including esophageal squamous cell carcinoma. In addition to its common side effects, including diarrhea, mucositis, neutropenia, and anemia, 5-FU ...
Keiki Nagaharu +8 more
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source