Results 71 to 80 of about 52,894 (243)

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

A randomised trial comparing 5-FU with 5-FU plus cisplatin in advanced pancreatic carcinoma

Annals of Oncology, 2002
Chemotherapy is moderately efficient as a treatment for pancreatic adenocarcinoma, but patient survival and quality of life has improved with this modality in some trials. In a previous phase II trial, 5-fluorouracil (5-FU) plus cisplatin (FUP) yielded a 26.5% response rate and a 29% survival rate at 1 year.
M, Ducreux, P, Rougier, J-P, Pignon, J-Y, Douillard, J-F, Seitz, R, Bugat, J-F, Bosset, Y, Merouche, J-L, Raoul, M, Ychou, A, Adenis, F, Berthault-Cvitkovic, M, Luboinski   +12 more
openaire   +2 more sources

Aspirin suppresses chemoresistance and enhances antitumor activity of 5-Fu in 5-Fu-resistant colorectal cancer by abolishing 5-Fu-induced NF-κB activation [PDF]

Scientific Reports, 2019
AbstractChemoresistance to 5-fluorouracil (5-Fu)-based chemotherapy is a leading obstacle in achieving effective treatment for colorectal cancer (CRC). Typically, NF-κB activation induced by the chemotherapeutics themselves is an important cause resulting in chemoresistance.
Fu Jinbo, Xu Yiming, Yang Yushan, Liu Yun, Ma Lulu, Zhang Yiyao   +5 more
openaire   +3 more sources

Quercetin enhances 5-fluorouracil-induced apoptosis in MSI colorectal cancer cells through p53 modulation [PDF]

, 2011
Purpose: Colorectal tumors (CRC) with microsatellite instability (MSI) show resistance to chemotherapy with 5-fluorouracil (5-FU), the most widely used pharmacological drug for CRC treatment.
A Preto, BB Aggarwal, BL Adamsen, C Rupnarain, CM Ribic, CP Xavier, Cristina P. R. Xavier, Cristina Pereira-Wilson, Cristovao F. Lima, CZ Wang, EF Wagner, F Bunz, F Bunz, FA Sinicrope, J Benhattar, J Gayet, J Liu, J Warusavitarne, JA McCubrey, JM Davies, K Soreide, KW Barbour, LR Coulthard, M Osaki, Mikkel Rohde, N Itoh, N Thompson, PG Rychahou, Q Hou, R Jover, R Seruca, R Shi, RA Subapriya Rajamanickam, RM Mader, S Bhushan, S Hector, S Huerta, S Mori, S Ramos, S Violette, XY Tang, YQ Zhang   +41 more
core   +1 more source

Inhibitory effect of the multi-target TKI, anlotinib, in 5-FU resistant colorectal cancer HCT-8/15 cells: down regulation of drug resistance-associated protein expression

Frontiers in Oncology
PurposeColorectal cancer is the most prevalent gastrointestinal malignancy. Treatment usually includes 5-fluorouracil (5-FU), oxaliplatin, and irinotecan, with 5-FU usually being the first choice.
Juan Liu, Haolin Sun, Xixi Zheng, Nina Ma, Xiaoling Liu, Ruizhen Cao, Bangwei Cao, Bing Liu   +7 more
doaj   +1 more source

Temperature and magnetism bi-responsive molecularly imprinted polymers: Preparation, adsorption mechanism and properties as drug delivery system for sustained release of 5-fluorouracil [PDF]

, 2015
This document is the Accepted Manuscript version of the following article: Longfei Li, Lin Chen, Huan Zhang, Yongshen Yang, Xuguang Liu, and Yongkang Chen, ‘Temperature and magnetism bi-responsive molecularly imprinted polymers: Preparation, adsorption ...
Chen, Lin, Chen, Yong, Li, Longfei, Liu, Xuguang, Yang, Yongzhen, Zhang, Huan   +5 more
core   +1 more source

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

Calbindin 2 (CALB2) regulates 5-fluorouracil sensitivity in colorectal cancer by modulating the intrinsic apoptotic pathway. [PDF]

PLoS ONE, 2011
The role of the calcium binding protein, Calbindin 2 (CALB2), in regulating the response of colorectal cancer (CRC) cells to 5-Fluorouracil (5-FU) was investigated.
Leanne Stevenson, Wendy L Allen, Irina Proutski, Gail Stewart, Louise Johnston, Karen McCloskey, Peter M Wilson, Daniel B Longley, Patrick G Johnston   +8 more
doaj   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Association between exposure to volatile organic compounds and female infertility: An NHANES analysis

Taiwanese Journal of Obstetrics & Gynecology
Objective: Infertility affects a large portion of the global population, with environmental, lifestyle, and biological factors contributing to its incidence.
Liang-Sien Chen, Hung-Keng Wu, Wen-Hsin Chang, Wei-Chu Wang, Chyi-Huey Bai   +4 more
doaj   +1 more source