Results 71 to 80 of about 12,458,805 (285)

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz   +8 more
wiley   +1 more source

Association between exposure to volatile organic compounds and female infertility: An NHANES analysis

Taiwanese Journal of Obstetrics & Gynecology
Objective: Infertility affects a large portion of the global population, with environmental, lifestyle, and biological factors contributing to its incidence.
Liang-Sien Chen, Hung-Keng Wu, Wen-Hsin Chang, Wei-Chu Wang, Chyi-Huey Bai   +4 more
doaj   +1 more source

Dipeptidyl-peptidase-4 (DPP-4) inhibitor ameliorates 5-flurouracil induced intestinal mucositis

BMC Cancer, 2019
Background Chemotherapy-induced alimentary mucositis (AM) is difficult to prevent and treatment is rarely effective. Recent study have been showed that glucagon-like peptide (GLP)-1 and GLP-2 has protective in chemotherapy-induced AM.
Jung Min Lee, In Kyung Yoo, Jae Min Lee, Seung Han Kim, Hyuk Soon Choi, Eun Sun Kim, Bora Keum, Yeon Seok Seo, Yoon Tae Jeen, Hoon Jai Chun, Hong Sik Lee, Soon Ho Um, Chang Duck Kim   +12 more
doaj   +1 more source

Both hMutSα and hMutSß DNA mismatch repair complexes participate in 5-fluorouracil cytotoxicity. [PDF]

PLoS ONE, 2011
Patients with advanced microsatellite unstable colorectal cancers do not show a survival benefit from 5-fluorouracil (5-FU)-based chemotherapy. We and others have shown that the DNA mismatch repair (MMR) complex hMutSα binds 5-FU incorporated into DNA ...
Akihiro Tajima, Moriya Iwaizumi, Stephanie Tseng-Rogenski, Betty L Cabrera, John M Carethers   +4 more
doaj   +1 more source

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

Table_1_Targeting Thymidylate Synthase Enhances the Chemosensitivity of Triple-Negative Breast Cancer Towards 5-FU-Based Combinatorial Therapy.doc

, 2023
BackgroundThe ongoing treatment modalities for breast cancer (BC) primarily rely on the expression status of ER, PR and HER-2 receptors in BC tissues. Our strategy of chemosensitization provides new insights to counter chemoresistance, a major obstacle ...
Sreekumar U. Aiswarya (11136633), Nair Hariprasad Haritha (11136615), Vinod Vijayakurup (11136618), Akbar Nawab (293152), Mundanattu Swetha (11136636), Maria V. Guijarro (11136642), Sankar Sundaram (10335804), Chittalakkottu Sadasivan (11136657), Archana Krishna (11136648), Nesteena K. Nestory (11136651), Ruby John Anto (11136663), Smitha V. Bava (11136654), Thomas Herlevich (11136645), Maria Zajac-Kaye (11136660), Vijai V. Alex (11136627), Areekkara Nisthul Amrutha (11136630), Nikhil Ponnoor Anto (11136621), Vijayasteltar B. Liju (11136624), Balachandran S. Vinod (11136639)   +18 more
core   +1 more source

Inhibitory effect of the multi-target TKI, anlotinib, in 5-FU resistant colorectal cancer HCT-8/15 cells: down regulation of drug resistance-associated protein expression

Frontiers in Oncology
PurposeColorectal cancer is the most prevalent gastrointestinal malignancy. Treatment usually includes 5-fluorouracil (5-FU), oxaliplatin, and irinotecan, with 5-FU usually being the first choice.
Juan Liu, Haolin Sun, Xixi Zheng, Nina Ma, Xiaoling Liu, Ruizhen Cao, Bangwei Cao, Bing Liu   +7 more
doaj   +1 more source

Clinical Manifestations, Outcomes, and Etiologies of Perinatal Stroke in Taiwan: Comparisons between Ischemic, and Hemorrhagic Stroke Based on 10-year Experience in A Single Institute

Pediatrics and Neonatology, 2017
Perinatal stroke is a common cause of established neurological sequelae. Although several risk factors have been identified, many questions regarding causes and clinical outcomes remain unanswered.
Chien-Chung Lee, Jainn-Jim Lin, Kuang-Lin Lin, Wai-Ho Lim, Kai-Hsiang Hsu, Jen-Fu Hsu, Ren-Huei Fu, Ming-Chou Chiang, Shih-Ming Chu, Reyin Lien   +9 more
doaj   +1 more source

A randomised trial comparing 5-FU with 5-FU plus cisplatin in advanced pancreatic carcinoma

Annals of Oncology, 2002
Chemotherapy is moderately efficient as a treatment for pancreatic adenocarcinoma, but patient survival and quality of life has improved with this modality in some trials. In a previous phase II trial, 5-fluorouracil (5-FU) plus cisplatin (FUP) yielded a 26.5% response rate and a 29% survival rate at 1 year.
M, Ducreux, P, Rougier, J-P, Pignon, J-Y, Douillard, J-F, Seitz, R, Bugat, J-F, Bosset, Y, Merouche, J-L, Raoul, M, Ychou, A, Adenis, F, Berthault-Cvitkovic, M, Luboinski   +12 more
openaire   +2 more sources

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source