Results 71 to 80 of about 9,064,090 (287)

Results of intraoperative 5-fluorouracil in patients undergoing trabeculectomy - pilot prial

Indian Journal of Ophthalmology, 1996
To study the effect of 5-Fluorouracil (5-FU) in glaucoma filtration surgery, 13 eyes of 12 patients with glaucoma were subjected to trabeculectomy with intraoperative one minute exposure of 50 mg/ml 5-FU. The average age of patients was 36.42 ± 18.
Shelat Binita, Rao B, Vijaya L, Revathi B, Garg Dinesh   +4 more
doaj  

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Dose reduction and toxicity according to gene polymorphisms and 5-FU-DR.

, 2016
Dose reduction and toxicity according to gene polymorphisms and 5-FU-DR.
Bruna Cerbelli (3133278), Marina Borro (440234), Claudia Sebastiani (3133269), Maurizio Simmaco (440241), Federica Mazzuca (3133257), Luca Marchetti (3133275), Andrea Botticelli (3133263), Giovanna Gentile (3133266), Paolo Marchetti (393307), Adriana Romiti (3133281), Luana Lionetto (3133254), Concetta Elisa Onesti (3133272), Mario Occhipinti (3133260), Lidia Strigari (51527)   +13 more
core   +1 more source

A randomised trial comparing 5-FU with 5-FU plus cisplatin in advanced pancreatic carcinoma

Annals of Oncology, 2002
Chemotherapy is moderately efficient as a treatment for pancreatic adenocarcinoma, but patient survival and quality of life has improved with this modality in some trials. In a previous phase II trial, 5-fluorouracil (5-FU) plus cisplatin (FUP) yielded a 26.5% response rate and a 29% survival rate at 1 year.
M, Ducreux, P, Rougier, J-P, Pignon, J-Y, Douillard, J-F, Seitz, R, Bugat, J-F, Bosset, Y, Merouche, J-L, Raoul, M, Ychou, A, Adenis, F, Berthault-Cvitkovic, M, Luboinski   +12 more
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Association between exposure to volatile organic compounds and female infertility: An NHANES analysis

Taiwanese Journal of Obstetrics & Gynecology
Objective: Infertility affects a large portion of the global population, with environmental, lifestyle, and biological factors contributing to its incidence.
Liang-Sien Chen, Hung-Keng Wu, Wen-Hsin Chang, Wei-Chu Wang, Chyi-Huey Bai   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Clinical Manifestations, Outcomes, and Etiologies of Perinatal Stroke in Taiwan: Comparisons between Ischemic, and Hemorrhagic Stroke Based on 10-year Experience in A Single Institute

Pediatrics and Neonatology, 2017
Perinatal stroke is a common cause of established neurological sequelae. Although several risk factors have been identified, many questions regarding causes and clinical outcomes remain unanswered.
Chien-Chung Lee, Jainn-Jim Lin, Kuang-Lin Lin, Wai-Ho Lim, Kai-Hsiang Hsu, Jen-Fu Hsu, Ren-Huei Fu, Ming-Chou Chiang, Shih-Ming Chu, Reyin Lien   +9 more
doaj   +1 more source