Results 51 to 60 of about 9,064,090 (287)

Apigenin enhances apoptosis induction by 5-fluorouracil through regulation of thymidylate synthase in colorectal cancer cells

Redox Biology, 2021
Although effective drugs have been developed, including 5-fluorouracil (5-FU), advanced colorectal cancer (CRC) shows low therapeutic sensitivity resulting from the development of 5-FU resistance.
Changwon Yang, Jisoo Song, Sunjae Hwang, Jungil Choi, Gwonhwa Song, Whasun Lim   +5 more
doaj   +1 more source

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

Image_1_Targeting Thymidylate Synthase Enhances the Chemosensitivity of Triple-Negative Breast Cancer Towards 5-FU-Based Combinatorial Therapy.jpeg

, 2023
BackgroundThe ongoing treatment modalities for breast cancer (BC) primarily rely on the expression status of ER, PR and HER-2 receptors in BC tissues. Our strategy of chemosensitization provides new insights to counter chemoresistance, a major obstacle ...
Sreekumar U. Aiswarya (11136633), Nair Hariprasad Haritha (11136615), Vinod Vijayakurup (11136618), Akbar Nawab (293152), Mundanattu Swetha (11136636), Maria V. Guijarro (11136642), Sankar Sundaram (10335804), Chittalakkottu Sadasivan (11136657), Archana Krishna (11136648), Nesteena K. Nestory (11136651), Ruby John Anto (11136663), Smitha V. Bava (11136654), Thomas Herlevich (11136645), Maria Zajac-Kaye (11136660), Vijai V. Alex (11136627), Areekkara Nisthul Amrutha (11136630), Nikhil Ponnoor Anto (11136621), Vijayasteltar B. Liju (11136624), Balachandran S. Vinod (11136639)   +18 more
core   +1 more source

Retrospective Analysis to Optimize the Detection of MET Exon 14 Skipping Mutations in Non-Small Cell Lung Cancer

Diagnostics
Our study optimized METex14 skipping mutation detection by analyzing 223 Oncomine™ Focus Assay-positive cases using Pan Lung Cancer PCR Panel and reverse transcription (RT)-PCR.
Jang-Jih Lu, Shu-Hui Tsai, Lee-Chung Lin, Tzong-Shi Chiueh   +3 more
doaj   +1 more source

Hypercapnic Ventilatory Response in the Weaning of Patients with Prolonged Mechanical Ventilation

Canadian Respiratory Journal, 2017
Objective. To investigate whether hypercapnic ventilatory response (defined as the ratio of the change in minute ventilation [ΔV˙E] to the change in end-tidal partial pressure of carbon dioxide [ΔPETCO2]) is a predictor of successful weaning in patients ...
Chung-Shu Lee, Ning-Hung Chen, Li-Pang Chuang, Chih-Hao Chang, Li-Fu Li, Shih-Wei Lin, Hsiung-Ying Huang   +6 more
doaj   +1 more source

5-fluorouracil Toxicity Mechanism Determination in Human Keratinocytes: in vitro Study on HaCaT

Prague Medical Report, 2018
5-fluorouracil (5-FU) and capecitabine therapy is often accompanied by palmar-plantar erythrodysesthesia (PPE) which is manifestation of 5-FU toxicity in keratinocytes. The main mechanisms of 5-FU action are thymidylate synthase (TS) inhibition which can
Jan Hartinger, Pavel Veselý, Martin Šíma, Irena Netíková, Eva Matoušková, Luboš Petruželka   +5 more
doaj   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Head and neck irradiation modulates pharmacokinetics of 5-fluorouracil and cisplatin

, 2017
Background: 5-fluorouracil (5-FU) and cisplatin (CDDP) are used to enhance radiotherapy (RT) effect for head and neck (HN) cancers. However, the effect of local RT on systemic chemotherapeutics remains unclear.
Hsieh, Chen-Hsi;Hou, Mei-Ling;Chiang, Meng-Hsuan;Tai, Hung-Chi;Tien, Hui-Ju;Wang, Li-Ying;Tsai, Tung-Hu;Chen, Yu-Jen, 王儷穎   +1 more
core   +1 more source

Table_1_Targeting Thymidylate Synthase Enhances the Chemosensitivity of Triple-Negative Breast Cancer Towards 5-FU-Based Combinatorial Therapy.doc

, 2023
BackgroundThe ongoing treatment modalities for breast cancer (BC) primarily rely on the expression status of ER, PR and HER-2 receptors in BC tissues. Our strategy of chemosensitization provides new insights to counter chemoresistance, a major obstacle ...
Sreekumar U. Aiswarya (11136633), Nair Hariprasad Haritha (11136615), Vinod Vijayakurup (11136618), Akbar Nawab (293152), Mundanattu Swetha (11136636), Maria V. Guijarro (11136642), Sankar Sundaram (10335804), Chittalakkottu Sadasivan (11136657), Archana Krishna (11136648), Nesteena K. Nestory (11136651), Ruby John Anto (11136663), Smitha V. Bava (11136654), Thomas Herlevich (11136645), Maria Zajac-Kaye (11136660), Vijai V. Alex (11136627), Areekkara Nisthul Amrutha (11136630), Nikhil Ponnoor Anto (11136621), Vijayasteltar B. Liju (11136624), Balachandran S. Vinod (11136639)   +18 more
core   +1 more source

MicroRNA-149 Increases the Sensitivity of Colorectal Cancer Cells to 5-Fluorouracil by Targeting Forkhead Box Transcription Factor FOXM1

Cellular Physiology and Biochemistry, 2016
Background/Aims: Previously, we have shown that microRNA (miR)-149 suppresses the migration and invasion of colorectal cancer (CRC) cells by targeting forkhead box transcription factor (FOXM1).
Xiaobei Liu, Tao Xie, Xiaobei Mao, Lijun Xue, Xiaoyuan Chu, Longbang Chen   +5 more
doaj   +1 more source