Results 61 to 70 of about 12,458,805 (285)

RBFOX3 Regulates the Chemosensitivity of Cancer Cells to 5-Fluorouracil via the PI3K/AKT, EMT and Cytochrome-C/Caspase Pathways

Cellular Physiology and Biochemistry, 2018
Background/Aims: RBFOX3, an RNA-binding fox protein, plays an important role in the differentiation of neuronal development, but its role in the chemosensitivity of hepatocellular carcinoma (HCC) to 5-FU is unknown.
Tianze Liu, Xiaojun Wu, Yizhuo Li, Wenjing Lu, Fufu Zheng, Changlin Zhang, Qian Long, Huijuan Qiu, Yixin Li, Qin Ge, Miao Chen, Xinfa Yu, Wangbing Chen, Hongyang Zhang, Wenlin Huang, Meihua Luo, Wuguo Deng, Liren Li   +17 more
doaj   +1 more source

Measurements of 5-FU Plasma Concentrations in Patients with Gastrointestinal Cancer: 5-FU Levels Reflect the 5-FU Dose Applied

Journal of Cancer Therapy, 2012
Introduction: 5-Fluorouracil (5-FU) is the basis of most combination chemotherapies for gastrointestinal tumors. It is generally well tolerated, but side-effects might require dose-adjustment. As adverse events are not specific to the 5-FU component of the chemotherapy-combination, i.e.
Martina Blaschke, Jutta Blumberg, Ulrike Wegner, Martin Nischwitz, Giuliano Ramadori, Silke Cameron   +5 more
openaire   +2 more sources

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

Incidence of complications following 5-fluorouracil with trabeculectomies

Indian Journal of Ophthalmology, 1993
To investigate the incidence of complications reportedly caused by the use of 5-fluorouracil (5-FU) in glaucoma filtering surgery, we performed trabeculectomy with 5-FU on 57 eyes of 56 patients with advanced glaucoma.
Thomas Ravi, Jacob Aby, Raju Renu, Gieser Stephen, Sen Subir   +4 more
doaj  

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

PFS of patients with normal and altered 5-FU-DR (p = 0.03).

, 2016
PFS of patients with normal and altered 5-FU-DR (p = 0.03).
Bruna Cerbelli (3133278), Marina Borro (440234), Claudia Sebastiani (3133269), Maurizio Simmaco (440241), Federica Mazzuca (3133257), Luca Marchetti (3133275), Andrea Botticelli (3133263), Giovanna Gentile (3133266), Paolo Marchetti (393307), Adriana Romiti (3133281), Luana Lionetto (3133254), Concetta Elisa Onesti (3133272), Mario Occhipinti (3133260), Lidia Strigari (51527)   +13 more
core   +1 more source

Results of intraoperative 5-fluorouracil in patients undergoing trabeculectomy - pilot prial

Indian Journal of Ophthalmology, 1996
To study the effect of 5-Fluorouracil (5-FU) in glaucoma filtration surgery, 13 eyes of 12 patients with glaucoma were subjected to trabeculectomy with intraoperative one minute exposure of 50 mg/ml 5-FU. The average age of patients was 36.42 ± 18.
Shelat Binita, Rao B, Vijaya L, Revathi B, Garg Dinesh   +4 more
doaj  

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Dose reduction and toxicity according to gene polymorphisms and 5-FU-DR.

, 2016
Dose reduction and toxicity according to gene polymorphisms and 5-FU-DR.
Bruna Cerbelli (3133278), Marina Borro (440234), Claudia Sebastiani (3133269), Maurizio Simmaco (440241), Federica Mazzuca (3133257), Luca Marchetti (3133275), Andrea Botticelli (3133263), Giovanna Gentile (3133266), Paolo Marchetti (393307), Adriana Romiti (3133281), Luana Lionetto (3133254), Concetta Elisa Onesti (3133272), Mario Occhipinti (3133260), Lidia Strigari (51527)   +13 more
core   +1 more source

Solid lipid-based nanoparticulate system for sustained release and enhanced in-vitro cytotoxic effect of 5-fluorouracil on skin Melanoma and squamous cell carcinoma.

PLoS ONE, 2023
The present study aimed to prepare solid lipid-based nanoparticles (SLNs) using Precirol® ATO 5 as solid lipid and Poloxamer 188 and Tween 80 as surfactant and co-surfactant respectively, and SLNs-derived gel for sustained delivery, enhanced in-vitro ...
Ahsan Ali, Asadullah Madni, Hassan Shah, Talha Jamshaid, Nasrullah Jan, Safiullah Khan, Muhammad Muzamil Khan, Muhammad Ahmad Mahmood   +7 more
doaj   +1 more source