Results 41 to 50 of about 12,458,805 (285)
, 2023 N6 methyladenosine (m6A), methylation at the sixth N atom of adenosine, is the most common and abundant modification in mammalian mRNAs and non-coding RNAs.
HongLong Yu (17700908) +7 more
core +1 more source
Redox Biology, 2021 Although effective drugs have been developed, including 5-fluorouracil (5-FU), advanced colorectal cancer (CRC) shows low therapeutic sensitivity resulting from the development of 5-FU resistance.
Changwon Yang +5 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Adolescents with high‐risk cancer face complex developmental, psychosocial, and ethical challenges that extend beyond disease‐directed treatment. Although international recommendations exist for communication, psychosocial care, pediatric palliative care, survivorship, and shared decision‐making, these have largely evolved within ...
Johanna M. C. Blom +15 more
wiley +1 more source
5-FU and FAC intra-tumoral distribution.
, 2020 Autoradiography of [14C]-5-FU (A) and of [18F]-FAC (B) in an organoid tumor section. H&E staining of that tumor section (C). Scale bar = 5 mm. Scatter plot of the pixel-to-pixel comparison for [18F]-FAC and [14C]-5-FU autoradiography signal (D).
John L. Humm (8720559) +6 more
core +1 more source
Hypercapnic Ventilatory Response in the Weaning of Patients with Prolonged Mechanical Ventilation
Canadian Respiratory Journal, 2017 Objective. To investigate whether hypercapnic ventilatory response (defined as the ratio of the change in minute ventilation [ΔV˙E] to the change in end-tidal partial pressure of carbon dioxide [ΔPETCO2]) is a predictor of successful weaning in patients ...
Chung-Shu Lee +6 more
doaj +1 more source
Topical delivery of 5-fluorouracil (5-Fu) by 3-alkylcarbonyl-5-Fu prodrugs
International Journal of Pharmaceutics, 2001 The solubilities in isopropyl myristate (SIPM) and pH 4.0 buffer (SAQ) and the partition coefficients between IPM and pH 4.0 buffer (KIPM:AQ) have been measured for a series of 3-alkylcarbonyl-5-fluorouracil prodrugs (3-AC-5-FU). The 3-AC-5-FU prodrugs were all 100 times more soluble in IPM and the first two members of the series were also more soluble
Department of Pharmaceutical Sciences, The University of Montana Campus Drive #1552, Missoula, Montana 59812-1552, USA ( host institution ) +2 more
openaire +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld +5 more
wiley +1 more source
, 2017 Background: 5-fluorouracil (5-FU) is employed to enhance radiotherapy (RT) effect. Here, we evaluated the influence of whole-pelvic irradiation on the pharmacokinetics (PK) of 5-FU in plasma and lymphatic system of rats as the experimental model ...
Hsieh, Chen-Hsi;Hou, Mei-Ling;Wang, Li-Ying;Tai, Hung-Chi;Tsai, Tung-Hu;Chen, Yu-Jen +1 more
core +1 more source
PLoS ONE, 2012 5-Fluorouracil (5-FU) is a commonly used drug for the treatment of malignant cancers. However, approximately 80% of patients undergoing 5-FU treatment suffer from gastrointestinal mucositis.
Chung-Ta Chang +9 more
doaj +1 more source
Molecules, 2023 This study investigates the development of topically applied non-invasive amino-functionalized silica nanoparticles (AMSN) and O-Carboxymethyl chitosan-coated AMSN (AMSN-CMC) for ocular delivery of 5-Fluorouracil (5-FU).
Adel Ali Alhowyan +7 more
doaj +1 more source