Molecules, 2023 This study investigates the development of topically applied non-invasive amino-functionalized silica nanoparticles (AMSN) and O-Carboxymethyl chitosan-coated AMSN (AMSN-CMC) for ocular delivery of 5-Fluorouracil (5-FU).
Adel Ali Alhowyan +7 more
doaj +1 more source
Uio-68-5-FU as a drug delivery platform for 5-FU
, 2022 The drug delivery application of Porous metal–organic frameworks (MOFs) have been investigated due to their unique structures which are built of inorganic nodes and organic ligands. In present study, Uio-68-5-FU was successfully prepared by applied for delivery of 5-fluorouracil (5-FU).
openaire +2 more sources
Locally-applied 5-fluorouracil-loaded slow-release patch prevents pancreatic cancer growth in an orthotopic mouse model [PDF]
, 2019 To obtain improved efficacy against pancreatic cancer, we investigated the efficacy and safety of a locally-applied 5-fluorouracil (5-FU)-loaded polymeric patch on pancreatic tumors in an orthotopic nude-mouse model.
CHO, DONG WOO +10 more
core +1 more source
Uio-66-5-FU as a drug delivery platform for 5-FU
, 2022 The drug delivery application of Porous metal–organic frameworks (MOFs) have been investigated due to their unique structures which are built of inorganic nodes and organic ligands. In present study, Uio-66-5-FU was successfully prepared by applied for delivery of 5-fluorouracil (5-FU).
openaire +1 more source
Quercetin synergistically induces sensitivity to 5-fluorouracil through p53 modulation in colorectal cancer cells [PDF]
, 2011 Colorectal tumors (CRC) with microsatellite instability (MSI) show resistance to chemotherapy with 5-fluorouracil (5-FU), the most widely used pharmacological drug for CRC treatment.
Lima, Cristóvão F. +2 more
core +1 more source
Diet and the risk of inflammatory bowel disease: A retrospective cohort study in Taiwan
Journal of the Formosan Medical AssociationBackground/purpose: The incidence of inflammatory bowel disease (IBD) rapidly increases in Asia, and western dietary pattern is suspected to be the major risk factor.
Ming Jung Meng +6 more
doaj +1 more source
Selective Chemical Labeling of Natural T Modifications in DNA. [PDF]
, 2015 We present a chemical method to selectively tag and enrich thymine modifications, 5-formyluracil (5-fU) and 5-hydroxymethyluracil (5-hmU), found naturally in DNA.
Balasubramanian, Shankar +3 more
core +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source
An RNA damage response network mediates the lethality of 5-FU in colorectal cancer
Cell Reports MedicineSummary: 5-fluorouracil (5-FU), a major anti-cancer therapeutic, is believed to function primarily by inhibiting thymidylate synthase, depleting deoxythymidine triphosphate (dTTP), and causing DNA damage.
Jung-Kuei Chen +19 more
doaj +1 more source
Clinical and cost-effectiveness of capecitabine and tegafur with uracil for the treatment of metastatic colorectal cancer: systematic review and economic evaluation [PDF]
, 2003 Objectives: To evaluate the clinical and costeffectiveness of capecitabine and tegafur with uracil (UFT/LV) as first-line treatments for patients with metastatic colorectal cancer, as compared with 5- fluorouracil/folinic acid (5-FU/FA) regimens.
Brewer, N. +3 more
core +1 more source