Results 31 to 40 of about 9,064,090 (287)

A comparative study of PALA, PALA plus 5-FU, and 5-FU in advanced breast cancer [PDF]

Cancer, 1985
Sixty-three patients with Stage IV breast carcinoma refractory to standard combination chemotherapy agents such as 5-fluorouracil (5-FU) were entered into a study to determine the efficacy of a multiple dose schedule of N-(phosphonacetyl)-L-aspartic acid (PALA) and whether the addition of PALA improves the therapeutic efficacy of 5-FU.
G B, Mann, G N, Hortobagyi, A U, Buzdar, H Y, Yap, M, Valdivieso   +4 more
openaire   +2 more sources

N6-methyladenosine methylation analysis of long noncoding RNAs and mRNAs in 5-FU-resistant colon cancer cells

, 2023
N6 methyladenosine (m6A), methylation at the sixth N atom of adenosine, is the most common and abundant modification in mammalian mRNAs and non-coding RNAs.
HongLong Yu (17700908), Zhiyong Zhou (339121), Xiaoqiang Niu (17700914), Huizi Li (6241586), Xingyao Su (17700911), Kan Hu (1410607), Shengxun Mao (12243353), Jie Lai (13047181)   +7 more
core   +1 more source

Mesoporous Silica Nanoparticles Coated with Carboxymethyl Chitosan for 5-Fluorouracil Ocular Delivery: Characterization, In Vitro and In Vivo Studies

Molecules, 2023
This study investigates the development of topically applied non-invasive amino-functionalized silica nanoparticles (AMSN) and O-Carboxymethyl chitosan-coated AMSN (AMSN-CMC) for ocular delivery of 5-Fluorouracil (5-FU).
Adel Ali Alhowyan, Mohd Abul Kalam, Muzaffar Iqbal, Mohammad Raish, Ahmed M. El-Toni, Musaed Alkholief, Aliyah A. Almomen, Aws Alshamsan   +7 more
doaj   +1 more source

Uio-66-5-FU as a drug delivery platform for 5-FU

, 2022
The drug delivery application of Porous metal–organic frameworks (MOFs) have been investigated due to their unique structures which are built of inorganic nodes and organic ligands. In present study, Uio-66-5-FU was successfully prepared by applied for delivery of 5-fluorouracil (5-FU).
openaire   +1 more source

EpCAM Aptamer Activated 5-FU-Loaded PLGA Nanoparticles in CRC Treatment; In vitro and In vivo study

, 2022
In this study, EpCAM aptamer-activated nanoparticles (Ap-NPs) were synthesized to enhance treatment efficiency in colorectal cancer (CRC). PLGA [poly (D, L-lactide-co-glycolide)] copolymer was fabricated by conjugation of COOH-PEG-NH2 to PLGA-COOH ...
Rezvan Najafi (5811593), Akram Jalali (13179807), Bahram Yavari (14138433), Yadollah Omidi (843100), Seyyed Shamsadin Athari (9715841)   +4 more
core   +1 more source

Progression free survival (PFS) acconding to gene polymorphisms and 5-FU degradation rate (5-FU-DR).

, 2016
Progression free survival (PFS) acconding to gene polymorphisms and 5-FU degradation rate (5-FU-DR).
Bruna Cerbelli (3133278), Marina Borro (440234), Claudia Sebastiani (3133269), Maurizio Simmaco (440241), Federica Mazzuca (3133257), Luca Marchetti (3133275), Andrea Botticelli (3133263), Giovanna Gentile (3133266), Paolo Marchetti (393307), Adriana Romiti (3133281), Luana Lionetto (3133254), Concetta Elisa Onesti (3133272), Mario Occhipinti (3133260), Lidia Strigari (51527)   +13 more
core   +1 more source

Diet and the risk of inflammatory bowel disease: A retrospective cohort study in Taiwan

Journal of the Formosan Medical Association
Background/purpose: The incidence of inflammatory bowel disease (IBD) rapidly increases in Asia, and western dietary pattern is suspected to be the major risk factor.
Ming Jung Meng, Jyun Huang, Yung Kuan Tsou, Yu Bin Pan, Cheng Tang Chiu, Yan Ting Lin, Puo Hsien Le   +6 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Combination of 5-FU and MDM2/4 peptide inhibitors as a promising strategy to enhance 5-FU induced nucleolar stress.

, 2022
The inactivation of tumor suppressor p53 is crucial for tumor onset and progression. Half of colorectal cancer cases carry wild-type p53 that is inactivated by the overexpression of MDM2 and MDM4, the main negative regulators of p53 activity [1].
Giulia Russo, Annalisa Pecoraro, Daniele Bravoco, Chiara Brignola, Annapina Russo., Francesco Merlino, Valeria La Pietra   +6 more
core  

Gemcitabine: Progress in the treatment of pancreatic cancer [PDF]

, 2001
Unresectable pancreatic cancer has a dismal prognosis with a median survival of 3-5 months in untreated disease. Since the introduction of gemcitabine, pancreatic cancer may no longer be regarded a chemotherapy-resistant tumor.
Heinemann, Volker
core   +1 more source