Curcumin Chemosensitizes 5-Fluorouracil Resistant MMR-Deficient Human Colon Cancer Cells in High Density Cultures [PDF]
, 2014 Objective Treatment of colorectal cancer (CRC) remains a clinical challenge, as more than 15% of patients are resistant to 5-Fluorouracil (5-FU)-based chemotherapeutic regimens, and tumor recurrence rates can be as high as 50–60%.
Buhrmann, Constanze +5 more
core +11 more sources
Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy [PDF]
, 2017 BACKGROUND. Actinic keratosis is a precursor to cutaneous squamous cell carcinoma. Long treatment durations and severe side effects have limited the efficacy of current actinic keratosis treatments.
Ahu Turkoz +18 more
core +2 more sources
Future of 5-fluorouracil in cancer therapeutics, current pharmacokinetics issues and a way forward [PDF]
, 2019 Background: In addition to exhibiting antitumor potential, antitumor drugs exhibit toxicity due to a poor pharmacokinetic profile. An enormous amount of research has been carried out and is still ongoing to obtain more targeted, potent, and safe drugs to
Abd-Rabou +39 more
core +1 more source
A DFT study of 5-fluorouracil adsorption on the pure and doped BN nanotubes [PDF]
, 2015 The electronic and adsorption properties of the pristine, Al-, Ga-, and Ge-doped BN nanotubes interacted with 5-fluorouracil molecule (5-FU) were theoretically investigated in the gas phase using the B3LYP density functional theory (DFT) calculations. It
Baei, M.T. +4 more
core +1 more source
High incidence of Angina pectoris in patients treated with 5-fluorouracil - A planned surveillance study with 102 patients [PDF]
, 2003 Objective: Angina pectoris, arrhythmic sudden death and myocardial infarction, all these cardiac events have occasionally been reported during 5-fluorouracil (5-FU) chemotherapy.
Lersch, C. +4 more
core +1 more source
Early growth response protein-1 promoter-mediated synergistic antitumor effect of hTERTC27 gene therapy and 5-flurorouracil on nasopharyngeal carcinoma [PDF]
, 2012 hTERTC27 is a newly constructed polypeptide that can induce telomere dysfunction. To study the synergistic antitumor effects of the hTERTC27 polypeptide driven by the early growth response protein-1 (Egr-1) promoter and chemotherapeutic 5-flurorouracil ...
Chen, S +11 more
core +1 more source
Comparison of gene expression in HCT116 treatment derivatives generated by two different 5-fluorouracil exposure protocols [PDF]
, 2004 Background Established colorectal cancer cell lines subjected to different 5-fluorouracil (5-FU) treatment protocols are often used as in vitro model systems for investigations of downstream cellular responses to 5-FU and to generate 5-FU-
De Angelis, Paula M +4 more
core +2 more sources
Capecitabine as second-line treatment for metastatic cholangiocarcinoma: A report of two cases [PDF]
, 2002 Background: The management of recurrent, metastatic cholangiocarcinoma still remains a problem since this tumor entity is classified as chemotherapy-resistant.
Heinemann, Volker +2 more
core +1 more source
Delivery of sTRAIL variants by MSCs in combination with cytotoxic drug treatment leads to p53-independent enhanced antitumor effects [PDF]
, 2013 Mesenchymal stem cells (MSCs) are able to infiltrate tumor tissues and thereby effectively deliver gene therapeutic payloads. Here, we engineered murine MSCs (mMSCs) to express a secreted form of the TNF-related apoptosis-inducing ligand (TRAIL), which ...
A Ashkenazi +46 more
core +1 more source
Pharmaceuticals, 2020 In order to limit 5-fluorouracil (5-FU) toxicity, some health agencies recommend evaluating dihydropyrimidine dehydrogenase (DPD) deficiency before any 5-FU treatment introduction.
Marine Dolat +9 more
doaj +1 more source