Results 101 to 110 of about 9,064,090 (287)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Investigation of the molecular and cellular effects of Shilajit on 5-fluorouracil (5-FU)-induced nephrotoxicity in rats [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): This study aimed to evaluate the protective effects of shilajit on 5-fluorouracil (5-FU)-induced nephrotoxicity in a rat model.Materials and Methods: Twenty male Sprague Dawley rats were divided into four groups: Control, 5-FU, shilajit ...
Mehmet Ezer, Melek Öztürkler, Kezban Yıldız Dalgınlı, Emine Atakisi, Hatice Beseren Havadar, Onur Atakisi   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Comparison of IC₅₀ of GC/5-FU, CS/5-FU and 5-FU for SW480 and SMMC-7721 cells (n = 3).

, 2013
Comparison of IC50 of GC/5-FU, CS/5-FU and 5-FU for SW480 and SMMC-7721 cells (n = 3).
Tao Wan (302796), Bing He (135034), Bingbing Zha (118060), Jiang Han (302799), Tao Ye (302804), Qing Li (84975), Wei Wang (17594), Hongzhi Xu (302803), Houxiang Chen (302801), Mingrong Cheng (302795), Weiping Zhu (302797), Fengxiao Yang (302802)   +11 more
core   +1 more source

Intralesional 5 fluorouracil in the management of hypertrophic oculofacial scar

Indian Journal of Ophthalmology. Case Reports
A 40-year-female came with chief complaints of scar on the lateral side of the right eye which was extending from lateral canthus to the inferior orbital rim associated with pain and redness over scar.
Gunjan Rathi, Rutuja Gawande, Nikhilesh Wairagade   +2 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Kung-Fu Exhibition program, May 5, 1984

, 1984
1984Established in 1963, the Seattle Kung Fu Club offers traditional martial arts classes for adults and children in Seattle's International District neighborhood.

core  

RREB1-mediated SUMOylation enhancement promotes chemoresistance partially by transcriptionally upregulating UBC9 in colorectal cancer

Frontiers in Pharmacology
Chemoresistance is a main cause of chemotherapy failure and tumor recurrence. The effects of global protein SUMOylation on chemoresistance in colorectal cancer (CRC) remains to be investigated.
Ya-nan Deng, Ying Chen, Shan Gao, Nan Zhang, Yinheng Luo, Shu Luo, Qiu Li, Xianghui Fu, Shufang Liang   +8 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Effects of 5-Fluorouracil on the Expression of Epigenetic Enzymes and Promoter Methylation of Selected Genes in Monolayer and Spheroid Cultures of Colorectal Cancer Cells [PDF]

Pharmaceutical Sciences
Background: Emerging evidence suggests that epigenetic mechanisms contribute to 5-fluorouracil (5-FU) resistance in colorectal cancer (CRC). However, there is limited research on the direct impact of 5-FU on epigenetic alterations in CRC.
Maryam Niknam, Masoumeh Varedi, Mozhdeh Zamani, Pooneh Mokarram, Fakhraddin Naghibalhossaini   +4 more
doaj   +1 more source