The Role of Serum 5-HIAA as a Predictor of Progression and an Alternative to 24-h Urine 5-HIAA in Well-Differentiated Neuroendocrine Neoplasms [PDF]
Biology, 2021 Our aim was to investigate the clinical utility of serum 5HIAA for disease surveillance and diagnostic purposes in a cohort of patients with well-differentiated neuroendocrine neoplasms (WD-NENs).
Maria Wedin +4 more
doaj +4 more sources
Enhancing immunotherapy efficacy in NSCLC through the combined use of phenelzine and Akkermansia muciniphila to regulate gut microbial metabolite 5-HIAA [PDF]
Journal for ImmunoTherapy of CancerBackground Improving the efficacy of anti-programmed death 1 (PD-1) monoclonal antibody (mAb) therapy remains a major challenge for cancer immunotherapy in non-small cell lung cancer (NSCLC). Gut microbial metabolites can influence immunotherapy efficacy.
Jie Zhao +18 more
doaj +4 more sources
Biomarker of urinary 5-HIAA as a valuable predictor of acute appendicitis [PDF]
Practical Laboratory Medicine, 2021 Background: Serotonin-containing cells are abundantly found in the appendix. Studies have shown that acute appendicitis is likely to be characterized by altered urinary 5-hydroxyindole acetic acid (5-HIAA), an active serotonin metabolite. The aim of this
Leila Haji Maghsoudi +4 more
doaj +3 more sources
5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer’s disease [PDF]
Acta Neuropathologica Communications, 2018 Serotoninergic activation which decreases brain Aβ peptides is considered beneficial in mouse models for Alzheimer’s disease (AD), but the mechanisms involved remain unclear.
Christian Klein +6 more
doaj +4 more sources
Low CSF 5-HIAA in Myoclonus Dystonia. [PDF]
Mov Disord, 2017 Peall KJ +7 more
europepmc +7 more sources
Measurement of urinary 5-HIAA: correlation between spot versus 24-h urine collection [PDF]
Endocrine Connections, 2019 Background: The 24-h urinary output of 5-hydroxyindoleacetic acid (5-HIAA) is used to monitor disease progression and treatment responses of neuroendocrine neoplasms (NENs).
Matilde Calanchini +5 more
doaj +2 more sources
Gender-Specific Effect of 5-HT and 5-HIAA on Threshold Level of Behavioral Symptoms and Sex-Bias in Prevalence of Autism Spectrum Disorder [PDF]
Frontiers in Neuroscience, 2020 Platelet hyperserotonemia in a subset of Autism Spectrum Disorder (ASD) probands, efficacy of selective serotonin reuptake inhibitors (SSRIs) in reducing behavioral deficits and gender-bias in normal serotonin (5-hydroxy tryptamine or 5-HT) synthesis ...
Barnali Chakraborti +13 more
doaj +2 more sources
Elevated Cerebrospinal fluid 5-hydroxyindoleacetic acid in Macaques Following Early Life Stress (ELS) and Inverse Association with Hippocampal Volume: Preliminary Implications for Serotonin-Related Function in Mood and Anxiety Disorders [PDF]
Frontiers in Behavioral Neuroscience, 2014 Background: Early life stress (ELS) is cited as a risk for mood and anxiety disorders, potentially through altered serotonin neurotransmission. We examined the effects of ELS, utilizing the variable foraging demand (VFD) macaque model, on adolescent ...
Jeremy D Coplan +14 more
doaj +4 more sources
GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA. [PDF]
Cell, 2022 De Giovanni M +5 more
europepmc +6 more sources
The diagnostic utility of urinary 5-HIAA and leucine-rich alpha-2 glycoprotein in acute appendicitis: a narrative review [PDF]
Frontiers in MedicineBackgroundAcute appendicitis (AA) remains diagnostically challenging despite its global prevalence. Current methods rely on clinical scoring systems (e.g., Alvarado score) and imaging (US, CT, and MRI). Urinary biomarkers like 5-hydroxyindoleacetic acid (
Yahiya Baig +2 more
doaj +2 more sources