The Role of Serum 5-HIAA as a Predictor of Progression and an Alternative to 24-h Urine 5-HIAA in Well-Differentiated Neuroendocrine Neoplasms [PDF]
Biology, 2021 Our aim was to investigate the clinical utility of serum 5HIAA for disease surveillance and diagnostic purposes in a cohort of patients with well-differentiated neuroendocrine neoplasms (WD-NENs).
Maria Wedin +4 more
doaj +7 more sources
Biomarker of urinary 5-HIAA as a valuable predictor of acute appendicitis [PDF]
Practical Laboratory Medicine, 2021 Background: Serotonin-containing cells are abundantly found in the appendix. Studies have shown that acute appendicitis is likely to be characterized by altered urinary 5-hydroxyindole acetic acid (5-HIAA), an active serotonin metabolite. The aim of this
Leila Haji Maghsoudi +4 more
doaj +6 more sources
Systemic Regulation of RAS/MAPK Signaling by the Serotonin Metabolite 5-HIAA. [PDF]
PLoS Genetics, 2015 Human cancer is caused by the interplay of mutations in oncogenes and tumor suppressor genes and inherited variations in cancer susceptibility genes. While many of the tumor initiating mutations are well characterized, the effect of genetic background ...
Tobias Schmid +5 more
doaj +9 more sources
5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer’s disease [PDF]
Acta Neuropathologica Communications, 2018 Serotoninergic activation which decreases brain Aβ peptides is considered beneficial in mouse models for Alzheimer’s disease (AD), but the mechanisms involved remain unclear.
Christian Klein +6 more
doaj +4 more sources
5-HIAA as a Potential Biological Marker for Neurological and Psychiatric Disorders. [PDF]
Adv Pharm Bull, 2019 Neurological and psychiatric disorders occur in about 6 percent of the global population indicating a significant amount of people suffering from neurological disorder on a varying range in day to day life. On an extensive view, there is a critical requirement for the development of an alternative biomarker for these conditions.
Jayamohananan H, Manoj Kumar MK, T P A.
europepmc +6 more sources
Low CSF 5-HIAA in Myoclonus Dystonia. [PDF]
Mov Disord, 2017 Peall KJ +7 more
europepmc +7 more sources
Gender-Specific Effect of 5-HT and 5-HIAA on Threshold Level of Behavioral Symptoms and Sex-Bias in Prevalence of Autism Spectrum Disorder [PDF]
Frontiers in Neuroscience, 2020 Platelet hyperserotonemia in a subset of Autism Spectrum Disorder (ASD) probands, efficacy of selective serotonin reuptake inhibitors (SSRIs) in reducing behavioral deficits and gender-bias in normal serotonin (5-hydroxy tryptamine or 5-HT) synthesis ...
Barnali Chakraborti +13 more
doaj +2 more sources
Measurement of urinary 5-HIAA: correlation between spot versus 24-h urine collection [PDF]
Endocrine Connections, 2019 Background: The 24-h urinary output of 5-hydroxyindoleacetic acid (5-HIAA) is used to monitor disease progression and treatment responses of neuroendocrine neoplasms (NENs).
Matilde Calanchini +5 more
doaj +2 more sources
5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, is responsible for complete Freund's adjuvant-induced thermal hyperalgesia in mice [PDF]
Molecular Pain, 2011 Background The role of serotonin (5-hydroxytrptamine, 5-HT) in the modulation of pain has been widely studied. Previous work led to the hypothesis that 5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, might by itself influence pain ...
Moessner Rainald +5 more
doaj +2 more sources
Transient elevation of serum 5-HIAA by dietary serotonin and distribution of 5-HIAA in serum protein fractions [PDF]
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2014 Introduction Dietary serotonin increases urinary secretion of 5-HIAA. A falsely elevated 5-HIAA may lead to incorrect suspicion of a neuroendocrine tumour. Therefore, we determined the effect and duration of dietary serotonin on serum 5-HIAA concentration. We also studied the distribution of 5-HIAA in serum fractions. Methods We used serum samples from
Niina Tohmola +5 more
openalex +4 more sources