Inhibition of 5-hydroxyindoleacetic acid to reduce neutrophil extracellular trap production improves lung condition in chronic obstructive pulmonary disease mice [PDF]
Annals of MedicineBackground Neutrophil extracellular trap (NET) correlate with chronic obstructive pulmonary disease (COPD) severity. Platelets can promote NET generation. However, serotonin alone or serotonin-deficient platelets do not adequately promote NET production.
Qiang Zeng +6 more
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CSF 5-HIAA and Nighttime Activity in Free-Ranging Primates [PDF]
Neuropsychopharmacology, 2000 Men with low CNS serotonin turnover, as measured by cerebrospinal fluid 5-hydroxyindoleacetic acid (CSF 5-HIAA) concentrations, exhibit aberrant circadian activity patterns characterized by disrupted sleep rhythms and daytime hyperactivity. To assess whether similar patterns are found in nonhuman primates we examined the relationships between CSF 5 ...
Patrick T. Mehlman
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Repetitive transcranial magnetic stimulation elevates the serum levels of neurotrophic factors and serotonin and its metabolites in patients with ischemic stroke [PDF]
Frontiers in NeurologyObjectiveRepetitive transcranial magnetic stimulation (rTMS) can effectively treat cognitive impairment in stroke patients; however, its mechanism of action remains unclear.
Wei Li +4 more
doaj +2 more sources
GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA. [PDF]
Cell, 2022 De Giovanni M +5 more
europepmc +4 more sources
Pre-gestational stress reduces the ratio of 5-HIAA to 5-HT and the expression of 5-HT1A receptor and serotonin transporter in the brain of foetal rat [PDF]
BMC Neuroscience, 2012 Background Many studies have found that stress before or during pregnancy is linked to an increased incidence of behavioural disorders in offspring.
Huang Yuejun +5 more
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Pancreas, 2012 5-Hydroxyindoleacetic acid (5-HIAA) is used for the evaluation of neuroendocrine tumors (NETs) but currently requires a 24-hour urine collection.We developed a gas chromatography mass spectroscopy-based plasma 5-HIAA assay. We compared 24-hour urine 5-HIAA values against plasma 5-HIAA values in 115 mixed-variety patients with NETs and in a subset of 72
Maria R. Tellez +4 more
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Is urinary 5-HIAA determination a valuable method in diagnosis of acute appendicitis in children?
Journal of Indian Association of Pediatric Surgeons, 2006 The aim of the study is to investigate the significance of spot urine 5-hydroxyindoleacetic acid (5-HIAA) levels in patients admitted with the suspicion of acute appendicitis.
Ozel S +4 more
doaj +2 more sources
Plasma 5-HIAA activity indicative of serotonergic disturbances in cognitively impaired, elderly patients experiencing postoperative delirium. [PDF]
Int J Geriatr Psychiatry, 2022 Heylen A +6 more
europepmc +3 more sources
5-Hydroxyindoleacetic acid as a biomarker for revealing perforation in acute appendicitis [PDF]
BMC GastroenterologyBackground The present study investigated the level of 5-hydroxyindoleacetic acid (5-HIAA) in perforated and nonperforated appendicitis patients. This issue is important for timely diagnosis of acute appendicitis complications and making decision about ...
Arash Mohammadi Tofigh +6 more
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