Results 31 to 40 of about 7,934 (184)

Homovanillic acid and 5-hydroxyindole acetic acid as biomarkers for dementia with Lewy bodies and coincident Alzheimer's disease: An autopsy-confirmed study. [PDF]

PLoS ONE, 2017
Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) are the two most common causes of dementia. Both pathologies often coexist, and AD patients with concomitant neocortical LB pathology (referred to as the Lewy body variant of AD) generally show
Satoru Morimoto, Masaki Takao, Hiroyuki Hatsuta, Yasushi Nishina, Tadashi Komiya, Renpei Sengoku, Yuta Nakano, Akiko Uchino, Hiroyuki Sumikura, Yuko Saito, Kazutomi Kanemaru, Shigeo Murayama   +11 more
doaj   +1 more source

Elevated Cerebrospinal fluid 5-hydroxyindoleacetic acid in Macaques Following Early Life Stress (ELS) and Inverse Association with Hippocampal Volume: Preliminary Implications for Serotonin-Related Function in Mood and Anxiety Disorders

Frontiers in Behavioral Neuroscience, 2014
Background: Early life stress (ELS) is cited as a risk for mood and anxiety disorders, potentially through altered serotonin neurotransmission. We examined the effects of ELS, utilizing the variable foraging demand (VFD) macaque model, on adolescent ...
Jeremy D Coplan, Sasha L Fulton, Wade eReiner, Andrea eJackowski, Venkatesh ePanthangi, Tarique D Perera, Jack M Gorman, Yung-Yu eHuang, Cheuk Y Tang, Patrick R Hof, Arie eKaffman, Andrew eDwork, Sanjay J Mathew, Joan eKaufman, John J Mann   +14 more
doaj   +1 more source

Impact of plasma 5-hydroxyindoleacetic acid, a serotonin metabolite, on clinical outcome in septic shock, and its effect on vascular permeability

Scientific Reports, 2021
Septic shock is characterized by dysregulated vascular permeability. We hypothesized that the vascular permeability of endothelial cells (ECs) would be regulated by serotonin via serotonin-Rho-associated kinase (ROCK) signaling. We aimed to determine the
Takeshi Tanaka, Masahiko Mori, Motohiro Sekino, Ushio Higashijima, Masahiro Takaki, Yoshiro Yamashita, Satoshi Kakiuchi, Masato Tashiro, Konosuke Morimoto, Osamu Tasaki, Koichi Izumikawa   +10 more
doaj   +1 more source

Increase of Urinary 5-Hydroxyindoleacetic Acid Excretion but Not Serum Chromogranin a Following Over-The-Counter 5-Hydroxytryptophan Intake

Canadian Journal of Gastroenterology, 2008
BACKGROUND: 5-hydroxyindoleacetic acid (5-HIAA) excretion is commonly measured for biochemical detection of carcinoid tumours. A 77-year-old woman was referred for elevated 24 h urine 5-HIAA excretion (510 μmol/day; normal is less than 45 μmol/day) and ...
Tisha Joy, Grace Walsh, Sonya Tokmakejian, Stan HM Van Uum   +3 more
doaj   +1 more source

Assessment of Serotonin Metabolite 5-hydroxyindoleacetic Acid Levels in Urine Sample for Diagnosis and Treatment Efficacy in Children with Dysfunctional Voiding and Their Interaction with Biofeedback Therapy

Journal of Urological Surgery, 2018
Objective:Dysfunctional voiding (DV), which is explained as an incoordination between the external urethral sphincter and the bladder, is a situation developing in neurologically normal children.
Bahadır Topuz, Giray Ergin, Burak Köprü, Turgay Ebiloğlu, Hasan Cem Irkılata, Yusuf Kibar, Musa Murat Dayanç   +6 more
doaj   +1 more source

Season of sampling and season of birth influence serotonin metabolite levels in human cerebrospinal fluid. [PDF]

PLoS ONE, 2012
BACKGROUND: Animal studies have revealed seasonal patterns in cerebrospinal fluid (CSF) monoamine (MA) turnover. In humans, no study had systematically assessed seasonal patterns in CSF MA turnover in a large set of healthy adults.
Jurjen J Luykx, Steven C Bakker, Eef Lentjes, Marco P M Boks, Nan van Geloven, Marinus J C Eijkemans, Esther Janson, Eric Strengman, Anne M de Lepper, Herman Westenberg, Kai E Klopper, Hendrik J Hoorn, Harry P M M Gelissen, Julian Jordan, Noortje M Tolenaar, Eric P A van Dongen, Bregt Michel, Lucija Abramovic, Steve Horvath, Teus Kappen, Peter Bruins, Peter Keijzers, Paul Borgdorff, Roel A Ophoff, René S Kahn   +24 more
doaj   +1 more source

Central nervous system monoaminergic activity in hip osteoarthritis patients with disabling pain: associations with pain severity and central sensitization

PAIN Reports, 2022
. Introduction:. Monoaminergic activity modulates nociceptive transmission in the central nervous system (CNS). Although pain is the most disabling symptom of osteoarthritis (OA), limited knowledge exists regarding the CNS mechanisms that amplify pain ...
Martin F. Bjurström, Kaj Blennow, Henrik Zetterberg, Mikael Bodelsson, Markus Waldén, Nicholas Dietz, Sara Hall, Oskar Hansson, Michael R. Irwin, Niklas Mattsson-Carlgren   +9 more
doaj   +1 more source

Pitfalls in the diagnosis of carcinoid syndrome

Family Medicine & Primary Care Review, 2016
Background . Carcinoid syndrome (CS ) is a rare syndrome, most commonly associated with neuroendocrine neoplasms (NEN s) of the small intestine. Carcinoid syndrome consists of diarrhea, vomiting, abdominal pain, cutaneous flushing, teleangiectasias ...
Dorota Kaczmarska-Turek, Magdalena Pryć, Aleksander Kuś, Mateusz Klukowski, Mikołaj Radziszewski, Marzanna Staszewska-Skurczyńska, Aneta Jańczyk, Katarzyna Dźwiarek, Tomasz Bednarczuk   +8 more
doaj   +1 more source

Application of Wastewater-Based Epidemiology for Tracking Human Exposure to Deoxynivalenol and Enniatins

Toxins, 2022
Wastewater-based epidemiology (WBE) is a promising biomonitoring approach with the potential to provide direct information on human intake and exposure to food contaminants and environmental chemicals.
Zane Berzina, Romans Pavlenko, Martins Jansons, Elena Bartkiene, Romans Neilands, Iveta Pugajeva, Vadims Bartkevics   +6 more
doaj   +1 more source

Serotonergic Modulators in Alzheimer's Disease: A Hope in the Hopeless Condition

Chemistry &Biodiversity, EarlyView.
ABSTRACT Alzheimer's disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Najlaa Hamed Almohmadi, Hayder M. Al‐Kuraishy, Ali I. Al‐Gareeb, Ali K. Albuhadily, Morkoss M. Fakhry, Athanasios Alexiou, Marios Papadakis, Gaber El‐Saber Batiha   +7 more
wiley   +1 more source