Results 111 to 120 of about 714 (147)
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Journal of Psychopharmacology, 2002
The effects of the repeated administration of milnacipran, a serotonin (5-HT)-noradrenaline reuptake inhibitor (SNRI), on the functional status of somatodendritic 5-HT 1A receptors, and postsynaptic 5-HT 1A receptors were explored using ...
Daisuke, Mochizuki +3 more
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The effects of the repeated administration of milnacipran, a serotonin (5-HT)-noradrenaline reuptake inhibitor (SNRI), on the functional status of somatodendritic 5-HT 1A receptors, and postsynaptic 5-HT 1A receptors were explored using ...
Daisuke, Mochizuki +3 more
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European Journal of Pharmacology, 1993
In binding studies, WAY 100,135 (N-tertiobutyl-3-[4-(2-methoxyphenyl)-piperazinyl]-2-phenylpropana mide) and (-)-tertatolol showed affinities (Ki) of 29 nM and 10 nM, respectively, at 5-HT1A receptors. In vivo, they both dose dependently blocked the flat-body posture and corticosterone secretion provoked by an action of the 5-HT1A receptor agonist, S ...
F, Lejeune +4 more
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In binding studies, WAY 100,135 (N-tertiobutyl-3-[4-(2-methoxyphenyl)-piperazinyl]-2-phenylpropana mide) and (-)-tertatolol showed affinities (Ki) of 29 nM and 10 nM, respectively, at 5-HT1A receptors. In vivo, they both dose dependently blocked the flat-body posture and corticosterone secretion provoked by an action of the 5-HT1A receptor agonist, S ...
F, Lejeune +4 more
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The Journal of Pharmacology and Experimental Therapeutics, 1994
In the rat, activation of 5-hydroxytryptamine1A (5-HT1A) receptors causes hypothermia and the 5-HT syndrome. The effects of three chemically dissimilar 5-HT1A agonists administered s.c. [8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), gepirone, and (+)4-[n-5-(methoxychroman-3-yl)n-propylamino]butyl-8-azaspiro++ +[4,5] decane-7,adione ((+) S-20499)]
P A, Scott +3 more
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In the rat, activation of 5-hydroxytryptamine1A (5-HT1A) receptors causes hypothermia and the 5-HT syndrome. The effects of three chemically dissimilar 5-HT1A agonists administered s.c. [8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), gepirone, and (+)4-[n-5-(methoxychroman-3-yl)n-propylamino]butyl-8-azaspiro++ +[4,5] decane-7,adione ((+) S-20499)]
P A, Scott +3 more
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5-HT1A receptors and alcohol preference
European Neuropsychopharmacology, 1993Abstract Microinjection and lesion studies support the involvement of presynaptic 5-HT1A receptors in the reduction of ethanol (EtOH) intake induced by the selective 5-HT1A receptor agonists 8-OH-DPAT and ipsapirone in selectively bred Wistar rats, with high preference for EtOH over water in a two-bottle free choice situation.
J. De Vry +3 more
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1997
Publisher Summary For 5-HT1A receptors, many potent and selective ligands belonging to different chemical classes such as aminotetralins, indolylalkylamines, ergolines, aporphines, arylpiperazines, and aryloxyalkylamines are available. The majority of these compounds are agonists or partial agonists.
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Publisher Summary For 5-HT1A receptors, many potent and selective ligands belonging to different chemical classes such as aminotetralins, indolylalkylamines, ergolines, aporphines, arylpiperazines, and aryloxyalkylamines are available. The majority of these compounds are agonists or partial agonists.
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5-HT1A receptor-related anxiolytics
Trends in Pharmacological Sciences, 1987Abstract The brain serotonergic system has been implicated in the psychopathology of anxiety states and in the mechanism of action of the benzodiazepines downstream to the modulation of the GABA receptor/chloride channel complex. Jo¨rg Traber and Thomas Glaser report on the novel anti-anxiety agents buspirone, gepirone and ipsapirone which directly ...
Jo¨rg Traber, Thomas Glaser
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European Journal of Pharmacology, 1996
The effect of repeated treatment with imipramine on the 5-HT1A receptor-mediated inhibition of a population spike was studied in the rat CA1 hippocampal region ex vivo. Serotonin (5-hydroxytryptamine, 5-HT) and the selective 5-HT1A receptor agonist 8-hydroxy-2-(dipropylamino)tetralin (8-OH-DPAT) decreased dose-dependently the amplitude of population ...
M, Bijak +4 more
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The effect of repeated treatment with imipramine on the 5-HT1A receptor-mediated inhibition of a population spike was studied in the rat CA1 hippocampal region ex vivo. Serotonin (5-hydroxytryptamine, 5-HT) and the selective 5-HT1A receptor agonist 8-hydroxy-2-(dipropylamino)tetralin (8-OH-DPAT) decreased dose-dependently the amplitude of population ...
M, Bijak +4 more
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European Journal of Pharmacology, 1997
Twelve homing pigeons were trained to discriminate the 5-HT1A receptor agonist flesinoxan (0.25 mg/kg p.o.) from its vehicle in a fixed ratio (FR) 30 two-key operant drug discrimination procedure. Tests for generalization and antagonism showed that compounds with agonistic action at the 5-HT1A receptor, such as 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino ...
J, Mos +4 more
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Twelve homing pigeons were trained to discriminate the 5-HT1A receptor agonist flesinoxan (0.25 mg/kg p.o.) from its vehicle in a fixed ratio (FR) 30 two-key operant drug discrimination procedure. Tests for generalization and antagonism showed that compounds with agonistic action at the 5-HT1A receptor, such as 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino ...
J, Mos +4 more
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Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2005
Mice exposed to various stresses, especially restrained-stress, revealed the anxiogenic effect detected by the light-dark test. Under this condition, a remarkable decrease in [35S]GTPgammaS binding to membranes from the prefrontal cortex, amygdala and hypothalamus of restrained-stress mice stimulated by the selective 5-HT1A receptor agonist 5 ...
Minoru, Narita +5 more
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Mice exposed to various stresses, especially restrained-stress, revealed the anxiogenic effect detected by the light-dark test. Under this condition, a remarkable decrease in [35S]GTPgammaS binding to membranes from the prefrontal cortex, amygdala and hypothalamus of restrained-stress mice stimulated by the selective 5-HT1A receptor agonist 5 ...
Minoru, Narita +5 more
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5-HT1A Receptors and Cardiovascular Control
1989Substantial evidence implicates 5-hydroxytryptamine (5-HT) neurones in the control of cardiovascular function. The precise nature of that role remains, however, undefined, a reflection in part of the plurality of 5-HT receptors and, in particular, the absence until recently of truly selective agonists and antagonists for these sites (Bradley et al ...
J. R. Fozard, A. K. Mir, A. G. Ramage
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