Results 91 to 100 of about 78,996,387 (176)

New Imide 5-HT1A Receptor Ligands – Modification of Terminal Fragment Geometry

Molecules, 2004
Two sets of new o-methoxyphenylpiperazine (MPP; series a) and 1,2,3,4-tetrahydroisoquinoline (THIQ; series b) derivatives, containing various imide moietiesderived from NAN190, were synthesized and evaluated in vitro for their ability to bind tothe ...
Ryszard Bugno, Aneta Kozioł, Beata Duszyńska, Maria J. Mokrosz, Andrzej J. Bojarski   +4 more
doaj   +1 more source

Influence of 5-HT1A and 5-HTTLPR genetic variants on the schizophrenia symptoms and occurrence of treatment-resistant schizophrenia

, 2015
Tea Terzić,1 Matej Kastelic,2 Vita Dolžan,2 Blanka Kores Plesničar11Ljubljana University Psychiatric Hospital, Ljubljana, Slovenia; 2Pharmacogenetics Laboratory, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana ...
Terzić T, Dolžan V, Plesničar BK, Kastelic M   +3 more
core  

Genetic interaction of OPRM1 and 5-HT1a.

, 2022
A significant gene-to-gene interaction between OPRM1 and 5-HT1a was found on conditioned pain modulation (CPM) in fibromyalgia (FM) and healthy controls.
Angelica Sandström (10790852), Martin Schalling (72177), Diana Kadetoff (10790861), Eva Kosek (196823), Jeanette Tour (10790855)   +4 more
core   +1 more source

Major Depressive Disorder With Non‐Suicidal Self‐Injury in Adolescents: Altered Morphological Inverse Divergence Gradient in Brain Structure and Gene Expression Patterns

Human Brain Mapping, Volume 47, Issue 15, October 15, 2026.
Using the morphometric inverse divergence gradient network (MIND‐Gd), this study shows that adolescents with major depressive disorder (MDD) and non‐suicidal self‐injury (NSSI) exhibit altered principal structural gradients relative to adolescents with MDD without NSSI, and that these gradient changes are spatially coupled to neurotransmitter receptor ...
Yan Zhang, Xinyuan Hu, Wei Wang, Jing Wang, Hongying Li, Yumei Wan, Jianlei Zhu, Fei Liu, Shiyue Tao, Duanwei Wang, Xiangtao Lin, Yingying Zhang, Hongmei Zhang, Yuandong Gong   +13 more
wiley   +1 more source

Alterações na ingestão de alimento após a injeção de 8-OH-DPAT e MM-77 no núcleo arqueado do hipotálamo [PDF]

, 2012
Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em NeurociênciasEstudos em nosso laboratório mostraram que 8-hidroxi-2-(di-npropilamino)-tetralina (8-OH-DPAT) injetado no Núcleo ...
Felício, Daniela
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5-HT1A agonists for levodopa-induced dyskinesia in Parkinson’s disease supplementary table

, 2023
Levodopa is the most effective agent for treating the symptoms of Parkinson’s disease (PD). However, levodopa-induced dyskinesia remains a significant complication that manifests after few years of treatment, for which therapeutic options remain limited.
Christine Sun (15409986), Philippe Huot (306666), Jawad Al-Kassmy (15313151)   +2 more
core   +1 more source

Comparison of High and Low Affinity Serotonin 1A Receptors by PET In Vivo in Nonhuman Primates

Journal of Pharmacological Sciences, 2012
Serotonin (5-HT) 1A receptors exist in high and low affinity states. Agonist ligands bind preferentially to the high affinity state receptors, providing a more functionally relevant measure than antagonist binding.
J.S. Dileep Kumar, Matthew S. Milak, Vattoly J. Majo, Jaya Prabhakaran, Pratap Mali, Lyudmila Savenkova, J. John Mann, Ramin V. Parsey   +7 more
doaj   +1 more source

Two Distinct Serotonin Receptors Co-mediate Non-photic Signals to the Circadian Clock

Journal of Pharmacological Sciences, 2013
Several lines of evidence indicate that serotonin type 7 (5-HT7) receptors play a critical role for non-photic resetting of the mammalian circadian clock; however, the contributions of other types of 5-HT receptors to non-photic entrainment are not yet ...
Kazumasa Horikawa, Kazuyuki Fuji, Yuka Fukazawa, Shigenobu Shibata   +3 more
doaj   +1 more source

Dual role of endogenous serotonin in 2,4,6-trinitrobenzene sulfonic acid-induced colitis

Frontiers in Pharmacology, 2016
Background and Aims: Changes in gut serotonin content have been described in Inflammatory Bowel Disease and in different experimental models of colitis: the critical role of this monoamine in the pathogenesis of chronic gastrointestinal inflammation is ...
Alberto eRapalli, Simona eBertoni, Valentina eArcaro, Francesca eSaccani, Andrea eGrandi, Valentina eVivo, Anna Maria eCantoni, Elisabetta eBarocelli   +7 more
doaj   +1 more source

The internalization of the 5-HT1A receptor in central neurons : development of cellular models for studying the underlying mechanisms and functional correlates

, 2012
La sérotonine (5-HT) joue un rôle majeur dans la modulation de nombreuses fonctions physiologiques et des déficits de la neurotransmission sérotoninergique sont associés à la dépression.
Bouaziz-Amar, Elodie
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