Results 81 to 90 of about 78,996,387 (176)

Obsessive–Compulsive Disorder: Comorbidity, Biomarkers, Circuits, and Treatment Strategies

MedComm, Volume 7, Issue 11, November 2026.
OCD has a high comorbidity with other psychiatric conditions, among which anxiety is the most frequent one. The shared genetic biomarkers and common neural circuits underlying the co‐occurrence of OCD and anxiety pave a new path for understanding the pathogenic mechanism of OCD and suggest tailored and integrative treatment therapies for OCD from the ...
Xiao‐Yang Zhang, Zi‐Hao Li, Li‐Ping Shen, Bing‐Qing Kong, Qi‐Peng Zhang, Ya Ke, Juan Tu, Fei Wang, Wing‐Ho Yung, Jing‐Ning Zhu   +9 more
wiley   +1 more source

Receptor 5-HT1A i ISRS: Escurçament de la resposta antidepressiva [PDF]

, 2017
Els fàrmacs antidepressius necessiten unes quantes setmanes per aconseguir una resposta clínica (Trivedi et al., 2006). Una possible explicació és que l’augment de la concentració de serotonina (5-HT) extracel·lular produïda pels inhibidors de la ...
Oller Canet, Sílvia
core  

Spiroxatrine derivatives towards 5-HT1A receptor selectivity

, 2020
Background: In our previous work, spiroxatrine was taken as reference compound to develop selective NOP ligands. Therefore, several triazaspirodecanone derivatives were synthesized.
Battisti U. M., Brasili L., Tait, Annalisa, Battisti, Umberto M., Tait A., Sorbi C., Sorbi, Claudia, Brasili, Livio   +7 more
core   +1 more source

A Sensitive Approach for the Determination of the Novel Antidepressant Vilazodone: Electrochemical Sensing Using a Boron‐Doped Diamond Electrode in Surfactant‐Containing Media

ChemistryOpen, Volume 15, Issue 11, November 2026.
The combination of BRBS with Tween 20 enhanced the VLD oxidation signal at ~+0.67 V through surfactant‐assisted adsorption and preconcentration on the BDD electrode surface, resulting in improved sensitivity and signal‐to‐noise ratio. In this study, VLD was also found to undergo oxidation via the piperazine ring through a 2e−/2H+ process at the boron ...
Birdem Bersu İlvan, Ipek Kucuk, Selenay Sadak, Hülya Silah, Bengi Uslu   +4 more
wiley   +1 more source

Effects of Tandospirone, a 5-HT1A Agonistic Anxiolytic Agent, on Haloperidol-Induced Catalepsy and Forebrain Fos Expression in Mice

Journal of Pharmacological Sciences, 2009
We studied the effects of tandospirone, a 5-HT1A agonistic anxiolytic agent, on haloperidol-induced catalepsy and forebrain Fos expression in mice. Haloperidol (0.5 mg/kg, i.p.) markedly increased the catalepsy time and enhanced Fos expression in the ...
Yukihiro Ohno, Saki Shimizu, Junta Imaki
doaj   +1 more source

The 5-HT1A Receptor Antagonist p-MPPI Blocks Responses Mediated by Postsynaptic and Presynaptic 5-HT1A Receptors

Pharmacology Biochemistry and Behavior, 1997
The present experiments examined the ability of the novel 5-HT1A receptor antagonist to block responses mediated by postsynaptic and presynaptic 5-HT1A receptors in vivo. Pretreatment with p-MPPI reduced or blocked the effect of the 5-HT1A receptor agonist 8-OH-DPAT on two responses mediated by postsynaptic 5-HT1A receptors, reduction of body ...
A R, Allen, A, Singh, Z P, Zhuang, M P, Kung, H F, Kung, I, Lucki   +5 more
openaire   +2 more sources

Opioid Modulation of Major Neurotransmitter Systems: Acute, Chronic, and Withdrawal Effects

European Journal of Neuroscience, Volume 64, Issue 9, November 2026.
Opioids are widely used but also frequently misused drugs that affect multiple neurotransmitter systems, including dopaminergic, glutamatergic, GABAergic, serotonergic, and cholinergic pathways. Opioid‐induced neuroadaptations depend on the duration of drug exposure, with distinct changes also emerging following drug discontinuation.
Daniela Novakova, Eliska Pritulova, Jiri Novotny   +2 more
wiley   +1 more source

Lateralization of the 5-HT1A receptors in the basolateral amygdala in metabolic and anxiety responses to chronic restraint stress

Amino Acids
Behavioral and functional studies describe hemispheric asymmetry in anxiety and metabolic behaviors in responses to stress. However, no study has reported serotonergic receptor (the 5-HT1A receptor) lateralization in the basolateral amygdala (BLA) in ...
Habib Valipour, Gholam Hossein Meftahi, Gila Pirzad Jahromi, Alireza Mohammadi   +3 more
doaj   +1 more source

Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 247-249, March 2025.
Umesh Singh, Jonathan A. Bernstein
wiley   +1 more source

Nature, nurture, and 5‐HT4R: Familial predisposition, not parental bonding, is associated with brain 5‐HT4R in a sex‐specific manner

Psychiatry and Clinical Neurosciences, Volume 80, Issue 11, Page 898-904, November 2026.
Background Major depressive disorder (MDD) aggregates in families. The neostriatum, key to reward and attachment circuits, has the highest density of serotonin 4 receptors (5‐HT4R). Striatal 5‐HT4R is low in MDD and linked to familial depression risk. Poor parental bonding increases depression risk, yet whether nature and nurture converge on 5‐HT4R is ...
Randi T. Kjær, Martin B. Jørgensen, Kristian H. R. Jensen   +2 more
wiley   +1 more source