Results 71 to 80 of about 78,996,387 (176)

(2,2-Diphenyl-[1,3]oxathiolan-5-ylmethyl)-(3-phenylpropyl)-amine: a Potent and Selective 5-HT1A Receptor Agonist

, 2009
Starting from compound 1, a previously reported a1D-adrenoceptorsantagonist, a new series of ligands acting at 5-HT1A serotoninreceptor were identified through simple structure modifications.Among them (2,2-diphenyl-[1,3]oxathiolan-5-yl-methyl)-(3 ...
Annalisa Tait, Rossella Gallesi, SORBI, Claudia, Gabriella Marucci, GALLESI, Rossella, BRASILI, Livio, G. Marucci, A. Cilia, Carla De Stefani, Antonio Cilia, Livio Brasili, TAIT, Annalisa, Claudia Sorbi, M. Buccioni, Michela Buccioni, C. De Stefani, Silvia Franchini, FRANCHINI, Silvia, PRANDI, adolfo, Adolfo Prandi   +19 more
core   +3 more sources

Discovery of a new series of 5-HT1A receptor agonists

, 2010
Starting from compounds previously identified as a1-adrenoceptor antagonists that were also found to bind to the 5-HT1A receptor, in an attempt to separate the two activities, a new series of 5-HT1A receptor agonists was identified and shown to have ...
BRASILI L., ANGELI P, FOSSA, PAOLA, TAIT A, POGGESI E, PRANDI A, SORBI C, BUCCIONI M, FRANCHINI S, CILIA A, BARALDI A   +10 more
core   +2 more sources

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

An Antihyperkinetic Action by the Serotonin 1A–Receptor Agonist Osemozotan Co-administered With Psychostimulants or the Non-stimulant Atomoxetine in Mice

Journal of Pharmacological Sciences, 2009
It has been demonstrated that treatment of hyperactive mice with psychostimulants produced a calming effect depending on serotonergic neurotransmission.
Rie Tsuchida, Masahiro Kubo, Mariko Kuroda, Yasuhiro Shibasaki, Norihito Shintani, Michikazu Abe, Katalin Köves, Hitoshi Hashimoto, Akemichi Baba   +8 more
doaj   +1 more source

Systematic profiling reveals broad G protein coupling and context‐dependent modulation of cyclic AMP by the orphan receptor GPR139

British Journal of Pharmacology, Volume 183, Issue 23, Page 6865-6882, December 2026.
Background and Purpose G protein‐coupled receptors (GPCRs) are major drug targets, yet many orphan receptors remain poorly characterized. GPR139 has been implicated in CNS disorders, including schizophrenia and depression, but its signalling mechanisms remain unclear.
Boris Trapkov, Hans Bräuner, Alexander Sebastian Hauser   +2 more
wiley   +1 more source

Disturbances in the FGFR1-5-HT1A Heteroreceptor Complexes in the Raphe-Hippocampal 5-HT System Develop in a Genetic Rat Model of Depression

Frontiers in Cellular Neuroscience, 2017
The FGFR1-5-HT1A heteroreceptor complexes are involved in neuroplasticity in the rat hippocampus and in the mesencephalic raphe 5-HT nerve cells. There exists a 5-HT1A protomer enhancement of FGFR1 protomer signaling.
Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Caitlin M. DuPont, Xiang Li, David Savelli, David Savelli, Davide Lattanzi, Ipsit Srivastava, Manuel Narváez, Michael Di Palma, Elisa Barbieri, Yuniesky Andrade-Talavera, Riccardo Cuppini, Yuji Odagaki, Miklos Palkovits, Patrizia Ambrogini, Maria Lindskog, Kjell Fuxe   +18 more
doaj   +1 more source

Advances in Multidimensional Molecular Mechanisms of Epilepsy and Precision Therapy Strategies

CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
Epilepsy arises from a multidimensional network imbalance, integrating genetic, inflammatory, and metabolic disruptions. This complexity drives neuronal hyperexcitability and underpins therapeutic challenges. Our review highlights how emerging precision strategies, from targeted molecular therapies to neuromodulation, offer a transformative path toward
Yimin Han, Jingxuan Xu, Yuntian Shen, Jitai Zhang, Xia Li, Xinlei Yao, Lei Qi, Hualin Sun   +7 more
wiley   +1 more source

Exhaustive CoMFA and CoMSIA analyses around different chemical entities: a ligand-based study exploring the affinity and selectivity profiles of 5-HT1A ligands

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
The 5-hydroxytryptamine (5-HT1A) receptors represent an attractive target in drug discovery. In particular, 5-HT1A agonists and partial agonists are deeply investigated for their potential role in the treatment of anxiety, depression, ischaemic brain ...
Sara Guariento, Silvia Franchini, Michele Tonelli, Paola Fossa, Claudia Sorbi, Elena Cichero, Livio Brasili   +6 more
doaj   +1 more source

Perospirone, a Novel Antipsychotic Drug, Inhibits Marble-Burying Behavior via 5-HT1A Receptor in Mice: Implications for Obsessive-Compulsive Disorder

Journal of Pharmacological Sciences, 2005
Perospirone is a novel atypical antipsychotic drug with dopamine (DA) D2- and serotonin (5-hydroxytryptamine, 5-HT) 5-HT2A-receptor antagonist, and 5-HT1A-receptor agonist properties.
Michihiko Matsushita, Nobuaki Egashira, Satoko Harada, Ryoko Okuno, Kenichi Mishima, Katsunori Iwasaki, Ryoji Nishimura, Michihiro Fujiwara   +7 more
doaj   +1 more source

Psilocybin as a Transdiagnostic Treatment for Eating Disorders and Comorbid Psychopathology: Implications for Clinical Nosology and Research Directions

International Journal of Eating Disorders, Volume 59, Issue 11, Page 2375-2388, November 2026.
ABSTRACT Objective Eating disorders (EDs) are characterized by high rates of psychiatric comorbidity and suboptimal treatment outcomes. There remain critical gaps in research, including the exploration of effective transdiagnostic interventions. This forum article examines the potential of psilocybin treatment (PT) as a transdiagnostic intervention for
Elena Koning, Jérémie Richard, Aaron Keshen   +2 more
wiley   +1 more source