Results 131 to 140 of about 167,106 (231)

Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors

Molecular Psychiatry
Abstract Classical psychedelic drugs show promise as a treatment for major depressive disorder and related psychiatric disorders. This therapeutic efficacy stems from long-lasting psychedelic-induced neuroplasticity onto prefrontal cortical neurons and is thought to require the postsynaptic expression of serotonin
Tyler G. Ekins, Chloe Rybicki-Kler, Tao Deng, Isla A. W. Brooks, Izabela Jedrasiak-Cape, Ethan Donoho, Omar J. Ahmed   +6 more
openaire   +3 more sources

In Vivo Serotonin 5-HT2A Receptor Availability and Its Relationship with Aggression Traits in Healthy Individuals: A Positron Emission Tomography Study with C-11 MDL100907. [PDF]

Int J Mol Sci, 2023
Kim JH, Kim HK, Son YD, Kim JH.
europepmc   +1 more source

Gain control of sensory input across polysynaptic circuitries in mouse visual cortex by a single G protein-coupled receptor type (5-HT2A)

Nature Communications
Response gain is a crucial means by which modulatory systems control the impact of sensory input. In the visual cortex, the serotonergic 5-HT2A receptor is key in such modulation.
Ruxandra Barzan, Beyza Bozkurt, Mohammadreza M. Nejad, Sandra T. Süß, Tatjana Surdin, Hanna Böke, Katharina Spoida, Zohre Azimi, Michelle Grömmke, Dennis Eickelbeck, Melanie D. Mark, Lennard Rohr, Ida Siveke, Sen Cheng, Stefan Herlitze, Dirk Jancke   +15 more
doaj   +1 more source

DISTRIBUTION OF 5-HT2A RECEPTOR IMMUNOREACTIVITY IN THE RAT HIPPOCAMPAL FORMATION

, 2009
The hippocampal formation is composed of three layered allocortical structures, including the dentate gyrus, the hippocampus proper (which is subdivided into tree fields: CA3, CA2, and CA1), and the subiculum (Sharfmann, Ann. N.Y. Acad. Sci., 911, 2000).
BOMBARDI, CRISTIANO, GRANDIS, ANNAMARIA
core  

The G protein biased serotonin 5-HT2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice. [PDF]

Front Mol Biosci, 2023
Pogorelov VM, Rodriguiz RM, Roth BL, Wetsel WC.   +3 more
europepmc   +1 more source

Beyond the 5-HT_2A Receptor: Classic and Nonclassic Targets in Psychedelic Drug Action. [PDF]

J Neurosci, 2023
Cameron LP, Benetatos J, Lewis V, Bonniwell EM, Jaster AM, Moliner R, Castrén E, McCorvy JD, Palner M, Aguilar-Valles A.   +9 more
europepmc   +1 more source

Effects of a psychedelic 5-HT2A receptor agonist on anxiety-related behavior and fear processing in mice. [PDF]

Neuropsychopharmacology, 2022
Pędzich BD, Rubens S, Sekssaoui M, Pierre A, Van Schuerbeek A, Marin P, Bockaert J, Valjent E, Bécamel C, De Bundel D.   +9 more
europepmc   +1 more source

Regulation of Transglutaminase by 5-HT2A Receptor Signaling and Calmodulin

, 2009
Transglutaminase (TGase), nature’s biological glue, catalyzes the post-translational modification of proteins by formation of intra- and intermolecular protein cross-links or by primary amine incorporation. TGase has various physiological functions, such
Dai, Ying
core  

5-HT2A receptor dysregulation in a schizophrenia relevant mouse model of NMDA receptor hypofunction. [PDF]

Transl Psychiatry, 2022
Nakao K, Singh M, Sapkota K, Fitzgerald A, Hablitz JJ, Nakazawa K.   +5 more
europepmc   +1 more source

Novel Tricyclic Compounds as 5‑HT2A Receptor Agonists for Treating Depression, Anxiety, Substance Abuse, and Headaches. [PDF]

ACS Med Chem Lett
Sabnis RW, Sabnis AR.
europepmc   +1 more source