Results 111 to 120 of about 167,106 (231)
Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.This study compared five antidepressants (paroxetine, sertraline, duloxetine, mirtazapine, and vortioxetine) in mice using EEG/EMG, revealing distinct effects on REM and NREM sleep. The figure illustrates changes in sleep architecture during the light phase (ZT0–12).
Junya Maruoka +6 more
wiley +1 more source
Puerarin Acts Through Brain Serotonergic Mechanisms to Induce Thermal Effects
Journal of Pharmacological Sciences, 2004 The present study was attempted to investigate the effect of puerarin, an isoflavone compound isolated from Pueraria lobata, on both the basal body temperature and pyrogenic fever in unanesthetized, restrained rats.
Fu-Shin Chueh +3 more
doaj +1 more source
Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.Current bladder cancer therapies can cause toxicity and bladder dysfunction. Brief intravesical‐like aripiprazole exposure reduced bladder cancer cell viability and was associated with redox stress and caspase‐3 activation, while ex vivo findings suggested preserved bladder structure and function, warranting further investigation as a potential ...
Liam A. O'Callaghan +3 more
wiley +1 more source
Addiction, Volume 121, Issue 6, Page 1541-1556, June 2026.Abstract Background and aims Recreational ketamine use has increased globally and is associated with psychiatric and cognitive concerns. The hippocampus in preclinical models shows damage and working‐memory disruption with repeated dosing. However, whether specific hippocampal subregions may differ in people with chronic ketamine use remains unclear ...
Yi‐Hsuan Liu +8 more
wiley +1 more source
Biophysical Validation of Serotonin 5-HT2A and 5-HT2C Receptor Interaction
, 2018 Data supporting "Biophysical Validation of Serotonin 5-HT2A and 5-HT2C Receptor ...
daniel felsing (5688335)
core +1 more source
Mechanism‐Based Polypharmacy as a Repurposing Strategy: The Case of D‐Cycloserine and Lurasidone
Clinical and Translational Science, Volume 19, Issue 6, June 2026.ABSTRACT Modern psychiatric treatment often necessitates polypharmacy, yet combination regimens carry significant risks of metabolic burden and drug–drug interactions. There is growing interest in and clinical acceptance of rational, mechanism‐based drug combinations that are designed around desirable pharmacological properties rather than trial and ...
Avery D. Franzen +3 more
wiley +1 more source
Editorial: 5-HT2A/2B/2C receptors, memory and neuropsychiatric disorders
Frontiers in Pharmacology, 2016 Alfredo eMeneses, Antonella eGasbarri
doaj +1 more source
Olanzapine differentially affects 5-HT2A (and 2C) receptor mRNA expression in the rat brain
, 2014 This study examined regional changes in rat brain mRNA levels encoding 5-HT2A and 5-HT2C receptors following chronic olanzapine treatment. The immediate effect (2 h after the last treatment) was a down-regulation of 5-HT2A receptor mRNA expression ...
Han, M +4 more
core +1 more source
Chaihu-Shugan San modulates hippocampal 5-HT2A and BDNF in PSD rats
The European Zoological JournalTo investigate the effects of Chaihu-Shugan San (CSS) on the mRNA expression levels of 5-hydroxytryptamine 2A receptor (5-HT2A) and brain-derived neurotrophic factor (BDNF), as well as the amelioration of depressive-like behaviours of PSD rats.
K. Jia, L. Feng, L. Qian
doaj +1 more source
, 2018 Serotonin2A receptors and glutamate signaling have been implicated in the pathophysiology and treatment of compulsive spectrum disorders. Schedule-Induced Polydipsia (SIP), characterized by excessive drinking under intermittent food reinforcement ...
Vilchez, Olga +10 more
core +1 more source