Results 111 to 120 of about 27,791 (179)

The prefrontal cortex as a target for the atypical antipsychotic RU-31 with 5-HT2A antagonistic activity in the treatment of cognitive symptoms

Research Results in Pharmacology
Introduction: Cognitive deficits in schizophrenia are poorly managed by current antipsychotics, making the 5-HT2A receptor a promising therapeutic target, given its influence on dopaminergic signaling in the prefrontal cortex (PFC) and its involvement in
Konstantin Y. Kalitin, Olga Y. Mukha, Viktor B. Voynov, Alexander A. Spasov   +3 more
doaj   +1 more source

Allosteric activation of the glutamate receptor mGlu2 by the serotonin receptor 5-HT2A

Nature Communications
G protein-coupled receptor (GPCR) dimers and higher-order oligomers are the subject of intense debates. The complexes formed between two or more different GPCRs enable the cell to integrate several signals.
Siyu Gai, Li Lin, Jiyong Meng, Yichen Wu, Li Xue, Chanjuan Xu, Qian Sun, Adrià Ricarte, James Dalton, Pedro Renault, Jesús Giraldo, Jean-Philippe Pin, Philippe Rondard, Jianfeng Liu   +13 more
doaj   +1 more source

In Vivo Serotonin 5-HT2A Receptor Availability and Its Relationship with Aggression Traits in Healthy Individuals: A Positron Emission Tomography Study with C-11 MDL100907. [PDF]

Int J Mol Sci, 2023
Kim JH, Kim HK, Son YD, Kim JH.
europepmc   +1 more source

The G protein biased serotonin 5-HT2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice. [PDF]

Front Mol Biosci, 2023
Pogorelov VM, Rodriguiz RM, Roth BL, Wetsel WC.   +3 more
europepmc   +1 more source

Beyond the 5-HT_2A Receptor: Classic and Nonclassic Targets in Psychedelic Drug Action. [PDF]

J Neurosci, 2023
Cameron LP, Benetatos J, Lewis V, Bonniwell EM, Jaster AM, Moliner R, Castrén E, McCorvy JD, Palner M, Aguilar-Valles A.   +9 more
europepmc   +1 more source

Effects of a psychedelic 5-HT2A receptor agonist on anxiety-related behavior and fear processing in mice. [PDF]

Neuropsychopharmacology, 2022
Pędzich BD, Rubens S, Sekssaoui M, Pierre A, Van Schuerbeek A, Marin P, Bockaert J, Valjent E, Bécamel C, De Bundel D.   +9 more
europepmc   +1 more source

Serotonergic Polymorphisms and Psychotic Disorders in Populations From North Spain [PDF]

, 2004
There is strong biological evidence relating alterations in the serotonergic system with mental disorders. These alterations may be originated at the DNA level by sequence mutations that alter the functioning of serotonin receptors and
Arranz, M.J. (M. J.), Beperet, M. (M.), Clark, D. (D.), Kerwin, R.W. (R. W.), Lai, T. (T.), Mata, I. (I.), Ortuño-Sanchez-Pedreño, F. (Felipe), Patiño-García, A. (Ana), Perez-Nievas, F. (F.), Richards, S. (S.), Sham, P. (P.), Sierrasesumaga, L. (Luis)   +11 more
core  

5-HT2A receptor dysregulation in a schizophrenia relevant mouse model of NMDA receptor hypofunction. [PDF]

Transl Psychiatry, 2022
Nakao K, Singh M, Sapkota K, Fitzgerald A, Hablitz JJ, Nakazawa K.   +5 more
europepmc   +1 more source

What's a brain: neuroanatomy and neurochemistry of anxiety disorders in dogs [PDF]

, 2011
This review deals with the neurocircuitry of fear and anxiety disorders, with the focus on neuroanatomy and neurochemistry. This knowledge is required to correctly diagnose and treat dogs with anxiety-related behavioral disorders.
Audenaert, Kurt, De Meester, Rudy, Dobbeleir, André, Peremans, Kathelijne, van Bree, Henri, Vandermeulen, Eva, Vermeire, Simon   +6 more
core   +1 more source

Gain control of sensory input across polysynaptic circuitries in mouse visual cortex by a single G protein-coupled receptor type (5-HT2A)

Nature Communications
Response gain is a crucial means by which modulatory systems control the impact of sensory input. In the visual cortex, the serotonergic 5-HT2A receptor is key in such modulation.
Ruxandra Barzan, Beyza Bozkurt, Mohammadreza M. Nejad, Sandra T. Süß, Tatjana Surdin, Hanna Böke, Katharina Spoida, Zohre Azimi, Michelle Grömmke, Dennis Eickelbeck, Melanie D. Mark, Lennard Rohr, Ida Siveke, Sen Cheng, Stefan Herlitze, Dirk Jancke   +15 more
doaj   +1 more source