Results 91 to 100 of about 167,106 (231)

A Single Dose of LSD Does Not Alter Gene Expression of the Serotonin 2A Receptor Gene (HTR2A) or Early Growth Response Genes (EGR1-3) in Healthy Subjects

Frontiers in Pharmacology, 2017
Rationale: Renewed interest has been seen in the use of lysergic acid diethylamide (LSD) in psychiatric research and practice. The repeated use of LSD leads to tolerance that is believed to result from serotonin (5-HT) 5-HT2A receptor downregulation.
Patrick C. Dolder, Edna Grünblatt, Edna Grünblatt, Edna Grünblatt, Felix Müller, Stefan J. Borgwardt, Matthias E. Liechti   +6 more
doaj   +1 more source

A direct interaction of PSD-95 with 5-HT2A serotonin receptors regulates receptor trafficking and signal transduction

, 2003
The serotonin (5-hydroxytryptamine) 2A receptor (5-HT2A) is an important G protein-coupled receptor (GPCR) that mediates the effects of hallucinogens and is the target of a number of commonly prescribed medications including atypical antipsychotics ...
Xia, Zongqi, Xia, Z., Gray, John A, Roth, Bryan L, Compton-Toth, B.A., Compton-Toth, Beth A, Beth A. Compton-Toth, Roth, B.L., Zongqi Xia, Bryan L. Roth, Gray, J.A., John A. Gray   +11 more
core   +1 more source

Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview

MedComm, Volume 7, Issue 6, June 2026.
The role of deuterium replacement in drug discovery, its progress, opportunities, and challenges. ABSTRACT Deuterium, the heavy isotope of hydrogen, has unfolded as a cornerstone in modern drug discovery due to its potential to influence metabolic stability and pharmacokinetic behavior.
Mukta Lele, Ajit Manchare, Swapnali Parit, Amol D. Gholap, Krishna Jadhav, Navnath Hatvate, Keshav Raj Paudel, Satish Rojekar   +7 more
wiley   +1 more source

REGULATION OF DENDRITIC SPINES BY 5-HT2A RECEPTOR SIGNALING PATHWAYS [PDF]

, 2015
Dendritic spines are small membranous protrusions from the dendrites of neuron, which are thought to serve as basic units of synaptic transmission, learning and memory.
Mi, Zhen
core  

Plaque Deposition Dependent Decrease in 5-HT2A Serotonin Receptor in AβPPswe/PS1dE9 Amyloid Overexpressing Mice

, 2010
Intrahippocampal injections of aggregated amyloid-beta (Abeta)1-42 in rats result in memory impairment and in reduction of hippocampal 5-HT2A receptor levels.
Stensbøl, Tine B, Peter Holm, Anders B. Klein, Martin A. Santini, Kleijn, Susana Aznar, Gitte M. Knudsen, Jens D. Mikkelsen, Ettrup, Anders, Mikkelsen, Jens D, El-Sayed, Mona, Anders Ettrup, Klein, Anders B, Susana Aznar, Anders B. Elvang, Tine B. Stensbøl, Elvang, Anders B, Knudsen, Gitte M, Holm, Peter, Mona El-Sayed, Santini, Martin A   +19 more
core   +1 more source

Japanese Cohort Study and Meta‐Analysis Demonstrate Significant Association Between Serotonin Transporter‐Linked Polymorphic Region and Schizophrenia

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
This study demonstrates a significant association between the 5‐HTTLPR polymorphism and schizophrenia risk. The short allele was significantly overrepresented in patients (OR = 1.39, p = 0.007), suggesting a potential contribution to schizophrenia risk.
Masao Miyachi, Toshiyuki Shirai, Shohei Okada, Kiriko Minami, Ryo Tsukamoto, Kentaro Mouri, Satoshi Okazaki, Ikuo Otsuka, Akitoyo Hishimoto   +8 more
wiley   +1 more source

The Tricyclic Antidepressant Clomipramine Increases Plasma Glucose Levels of Mice

Journal of Pharmacological Sciences, 2003
: Effects of the tricyclic antidepressant clomipramine on plasma glucose levels in mice were studied. Clomipramine at doses ranging 5 – 20 mg/kg elicited significant hyperglycemia in mice.
Yumi Sugimoto, Kiyo Inoue, Jun Yamada
doaj   +1 more source

Activation of 5-HT2A receptor disrupts rat maternal behavior

Neuropharmacology, 2018
Serotonin 5-HT2A receptor is widely distributed in the central nervous system and plays an important role in sensorimotor function, emotion regulation, motivation, executive control, learning and memory. We investigated its role in rat maternal behavior, a naturalistic behavior encompassing many psychological functions that the 5-HT2A receptor is ...
Gao, Jun, Wu, Ruiyong, Davis, Collin, Li, Ming   +3 more
openaire   +3 more sources

The Effects of Serotonin Receptor Antagonists on Contraction and Relaxation Responses Induced by Electrical Stimulation in the Rat Small Intestine

, 2014
Background: The main source of 5-HT in body is in enterchromafin cells of intestine, different studies mentioned different roles for endogenous 5-HT and receptors involved and it is not clearified the mechanism of action of endogenous 5-HT. Objectives:
Farideh A. Javid, Javid, Farideh A., Mashhadi, Farzaneh Farajian, Robert J. Naylor, Farzaneh Farajian Mashhadi, Naylor, Robert J.   +5 more
core   +1 more source

Pharmacological Management, Safety, and Outcomes in Bipolar Disorder: An Integrated Narrative Review of Clinical and Translational Evidence

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
This graph summarizes bipolar disorder management, showing pharmacological treatments including lithium, valproate, antipsychotics, combination therapy, and emerging agents. It links these treatments to outcomes such as relapse reduction, mortality benefits, and cognitive effects, while highlighting safety issues, poor adherence, pregnancy risks, and ...
Gudisa Bereda
wiley   +1 more source