Results 121 to 130 of about 167,106 (231)

Changes in 5-HT2A Receptor Expression in Untreated, de novo Patients with Parkinson's Disease

, 2014
Background: Serotonin (5-HT) has long been implied in the pathophysiology of Parkinson's disease (PD). In addition, the 5-HT2A receptor is associated with the regulation of motor function and mood. Objective: To assess regional 5-HT2A receptor expression
Temel, Yasin, Leentjens, Albert F. G., van Kroonenburgh, Marinus J. P. G., Leentjens, Albert F. G.; id_orcid, Melse, Maartje, Tan, Sonny K. H.   +5 more
core   +1 more source

Allosteric activation of the glutamate receptor mGlu2 by the serotonin receptor 5-HT2A

Nature Communications
G protein-coupled receptor (GPCR) dimers and higher-order oligomers are the subject of intense debates. The complexes formed between two or more different GPCRs enable the cell to integrate several signals.
Siyu Gai, Li Lin, Jiyong Meng, Yichen Wu, Li Xue, Chanjuan Xu, Qian Sun, Adrià Ricarte, James Dalton, Pedro Renault, Jesús Giraldo, Jean-Philippe Pin, Philippe Rondard, Jianfeng Liu   +13 more
doaj   +1 more source

Schizophrenia and the 5-HT2A receptor gene

The Lancet, 1996
Harrison, P, Geddes, J
openaire   +2 more sources

Characterization of the 5-HT2A serotoninergic receptor in human placental choriocarcinoma cells lines

, 2005
We have recently demonstrated a mitogenic effect of serotonin via stimulation of 5-HT2A receptors in placental choriocarcinoma cell lines, JEG-3 and BeWo.
Arseneault, Madeleine, Vaillancourt, Cathy   +1 more
core   +1 more source

The prefrontal cortex as a target for the atypical antipsychotic RU-31 with 5-HT2A antagonistic activity in the treatment of cognitive symptoms

Research Results in Pharmacology
Introduction: Cognitive deficits in schizophrenia are poorly managed by current antipsychotics, making the 5-HT2A receptor a promising therapeutic target, given its influence on dopaminergic signaling in the prefrontal cortex (PFC) and its involvement in
Konstantin Y. Kalitin, Olga Y. Mukha, Viktor B. Voynov, Alexander A. Spasov   +3 more
doaj   +1 more source

Characterization of the 5-HT(7) receptor as a new therapeutic target for the treatment of pain [PDF]

, 2012
[eng] The work showed in this Thesis has been part of the “5-HT7 and neuropathic pain” project in the pharmaceutical company Esteve. Thus, the aim of this Thesis was in line with the goal of the 5-HT7 project at Esteve, focused on drug discovery of 5-HT7
Brenchat Barberà, Àlex
core  

The role of 5-HT2A vs. 5-HT2C receptor subtypes in haloperidol-induced dyskinetic effects

, 2006
Acute and chronic administration of typical antipsychotic (AP) drugs indures extrapyramidal side effects (EPS) and tardive dyskinesia (TD), respectively.
Oraha, Alhan
core  

Identification of a rat glomerular mesangial cell mitogenic 5-HT2A receptor

, 1995
Previous studies have demonstrated the presence of mitogenic serotonin [i.e., 5-hydroxytryptamine (5-HT)] receptors on glomerular mesangial cells and have linked those receptors to a complicated array of intracellular and autocrine/paracrine signaling ...
J. R. Raymond, M. N. Garnovskaya, C. G. Nebigil, R. F. Spurney   +3 more
core   +1 more source

Small-Molecule Heterocyclic Compounds: Gq-Biased Agonists for the 5-HT2A Receptor in Neuropsychiatric Treatment. [PDF]

ACS Med Chem Lett, 2023
Kargbo RB.
europepmc   +1 more source

Species differences in 5-HT2A receptors: cloned pig and rhesus monkey 5-HT2A receptors reveal conserved transmembrane homology to the human rather than rat sequence

, 1995
Pig and rhesus monkey 5-HT2A receptor cDNA clones were isolated. The pig and rhesus monkey clones encode proteins that share a 94% and 95% homology, respectively, with the rat 5-HT2A receptor, and a 97% and > 99% homology, respectively, with the human 5 ...
Baez, Melvyn, Nelson, David L, Kursar, J.David, Johnson, Michael P   +3 more
core   +1 more source