Results 111 to 120 of about 12,448,100 (233)

Maternal O‐GlcNAc Transferase Is Required for the Asymmetry of Epigenetic Modifications in Mouse Zygotes

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
OGT inhibition during in vitro oocyte maturation disrupts epigenetic asymmetry in the zygote. It reduces male pronuclear size and eliminates DNA methylation asymmetry by decreasing H3K9me2‐mediated 5mC protection in the female pronucleus and suppressing TET3‐dependent DNA demethylation in the male pronucleus.
Haoxue Wang, Dan Liu, Shinnosuke Honda, Shuntaro Ikeda   +3 more
wiley   +1 more source

Diesel exhaust and house dust mite allergen lead to common changes in the airway methylome and hydroxymethylome. [PDF]

, 2018
Exposures to diesel exhaust particles (DEP) from traffic and house dust mite (HDM) allergens significantly increase risks of airway diseases, including asthma. This negative impact of DEP and HDM may in part be mediated by epigenetic mechanisms.
Baccarelli, Andrea, Brandt, Eric B, Burleson, JD, Chen, Xiaoting, Ji, Hong, Weirauch, Matthew T, Zhang, Xiang, Zhang, Xue   +7 more
core  

Defending the genome from the enemy within:mechanisms of retrotransposon suppression in the mouse germline [PDF]

, 2013
The viability of any species requires that the genome is kept stable as it is transmitted from generation to generation by the germ cells. One of the challenges to transgenerational genome stability is the potential mutagenic activity of transposable ...
A Aravin, A Dupressoir, A Dupressoir, A Dupressoir, A Fadloun, A Inagaki, A Inoue, A Inoue, A Meissner, A Prokhortchouk, A Puech, A Sookdeo, A Tsumura, A Vourekas, AA Aravin, AA Aravin, AA Aravin, AA Zabolotneva, AE Peaston, AR Muotri, AR Muotri, B Hendrich, BH Schrans-Stassen, C Chen, C Lu, C Popp, C-X Song, C-X Song, CE Nestor, CG Lian, CM Davis, CP Walsh, D Bourc’his, D Bourc’his, D Branciforte, D Guallar, D Haig, D Lucifero, D Lucifero, D Reiss, D Ribet, D Ribet, D Ribet, D Sproul, D Wolf, D Wolf, DA Kramerov, DC Hancks, DJ Lees-Murdock, DM Maatouk, Donncha S. Dunican, DS Dunican, DT Ting, E Beyret, E Beyret, E Khazina, E Li, EB Chuong, EL Kuff, ES Lander, F Santos, F Yang, FD Araujo, G Hutvagner, G Velasco, GD Evrony, H Cedar, H Cedar, H Heyn, H Kano, H Khan, H Kobayashi, H Stroud, HJ Cooke, HM Rowe, HM Rowe, HM Rowe, I Cantone, I Martín Caballero, I Suetake, IA Maksakova, Ian R. Adams, J Borgel, J Brennecke, J Chen, J Gimenez, J Lange, J Reichmann, J Reichmann, J Rossant, J Sharif, J Xiol, J-H Ng, JA Hackett, JA Hackett, JA Yoder, James H. Crichton, JD Lewis, JK Baillie, JL Garcia-Perez, JL Goodier, JN Athanikar, JO Kriegs, JP Reddington, JP Reddington, JP Thomson, JP Thomson, JV Moran, K Dennis, K Hata, K Hayashi, K Hisada, K Kurimoto, K Myant, K Zheng, K Zheng, KP Koh, L Jackson-Grusby, L Ma, L Piko, L Shen, L-Q Sun, LK Hutnick, M Abe, M Chotalia, M Denne, M Dewannieux, M Dewannieux, M Dewannieux, M Freitag, M Kaneda, M Kaneda, M Ko, M Ko, M Leeb, M Okano, M Reuter, M Reuter, M Ruggiu, M Saitou, M Shoji, M Tachibana, M Tahiliani, M Weber, M Wiench, M Xu, MA Carmell, Marie MacLennan, MC Ward, MM Dawlaty, MM Dawlaty, MM Karimi, MT Romanish, N Bannert, N Gilbert, N Lane, N Mathioudakis, N Reynolds, N Yang, N Zamudio, OH Tam, P Hajkova, P Hajkova, PJ Skene, Q Feng, Q Yan, R Brunmeir, R Burdick, R Fuente De La, R Illingworth, R Lister, R Rebollo, R Shukla, R Yaman, R Öllinger, RH Waterston, Richard R. Meehan, RJ DeBerardinis, RJA Frost, RR Meehan, S Chuma, S Fazio De, S Guibert, S Ito, S Ito, S Kagiwada, S Kaufmann, S Kuntz, S Kuramochi-Miyagawa, S Kuramochi-Miyagawa, S Kuramochi-Miyagawa, S Kuramochi-Miyagawa, S Mi, S Milutinovic, S Salle La, S Schütt, S Seisenberger, S Solyom, S Takebayashi, S Yamaguchi, S-H Lee, SA Smallwood, SA Trelogan, SB Rothbart, SFC Soper, SK Mahadevaiah, SL Martin, SL Martin, SL Martin, SL Mathias, SP Sripathy, SS Tanaka, ST Grivna, T Matsui, T Singer, T Tanaka, T Watanabe, T Watanabe, T Watanabe, T-P Gu, TS Macfarlan, UM Galli, V Chapman, VV Vagin, W Deng, W Filipowicz, W Seifarth, W Wei, W Yan, WA Pastor, X Cai, X Nan, Y Kato, Y Seki, Y Tao, Y Unhavaithaya, Y Yabuta, Y Yotsuyanagi, Y-Q Su, Z Li, ZD Smith, ZD Smith   +241 more
core   +2 more sources

Environmental Epigenetics and Genome Flexibility: Focus on 5-Hydroxymethylcytosine

International Journal of Molecular Sciences, 2020
Convincing evidence accumulated over the last decades demonstrates the crucial role of epigenetic modifications for mammalian genome regulation and its flexibility.
O. Efimova, A. S. Koltsova, M. Krapivin, A. Tikhonov, A. Pendina   +4 more
semanticscholar   +1 more source

5-hydroxymethylcytosine DNA glycosylase activity in mammalian tissue

Biochemical and Biophysical Research Communications, 1988
The enzymatic release of 5-hydroxymethylcytosine from T2 bacteriophage DNA was effected by an extract of calf thymus. Like the previously described 5-hydroxymethyluracil DNA glycosylase, 5-hydroxymethylcytosine DNA glycosylase was not detectable in bacterial extracts.
S V, Cannon, A, Cummings, G W, Teebor
openaire   +2 more sources

Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin, Chen Qian, Wenhao Li, Qihan Wang, Qifeng Sheng, Zheqing Chen, Wei Zhang, Wenming Li, Gaoran Ge, Zhanjun Yan, Dechun Geng   +10 more
wiley   +1 more source

5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers

Cell Research, 2017
DNA modifications such as 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are epigenetic marks known to affect global gene expression in mammals.
Wenshuai Li, Xu Zhang, Xingyu Lu, L. You, Yanqun Song, Zhongguang Luo, Jun Zhang, Ji Nie, Wanwei Zheng, Diannan Xu, Ya-Ping Wang, Yuanqiang Dong, Shulin Yu, Jun-Feng Hong, Jianping Shi, H. Hao, F. Luo, Luchun Hua, P. Wang, X. Qian, Fang Yuan, Lian-Huan Wei, M. Cui, Taiping Zhang, Q. Liao, M. Dai, Ziwen Liu, Ge Chen, Katherine R Meckel, S. Adhikari, G. Jia, M. Bissonnette, Xinxiang Zhang, Yupei Zhao, Wei Zhang, Chuan He, Jie Liu   +36 more
semanticscholar   +1 more source

5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic and predictive biomarkers for coronary artery disease

Clinical Epigenetics, 2020
The 5-hydroxymethylcytosine (5hmC) DNA modification is an epigenetic marker involved in a range of biological processes. Its function has been studied extensively in tumors, neurodegenerative diseases, and atherosclerosis. Studies have reported that 5hmC
Chaoran Dong, Jiemei Chen, Ji-lin Zheng, Yiming Liang, Tao Yu, Yu-peng Liu, Feng Gao, Jie Long, Hangyu Chen, Qianhui Zhu, Zilong He, Songnian Hu, Chuan He, Jian Lin, Yida Tang, Haibo Zhu   +15 more
semanticscholar   +1 more source

Environmental enrichment modulates 5-hydroxymethylcytosine dynamics in hippocampus

Genomics, 2014
Gene-environment interactions mediated at the epigenetic level may provide an initial step in delivering an appropriate response to environmental changes. 5-Hydroxymethylcytosine (5hmC), a DNA base derived from 5-methylcytosine (5mC), accounts for ~40% of modified cytosine in the brain and has been implicated in DNA methylation-related plasticity.
Irier, Hasan, Street, R. Craig, Dave, Ronak, Lin, Li, Cai, Catherine, Davis, Timothy Hayden, Yao, Bing, Cheng, Ying, Jin, Peng   +8 more
openaire   +2 more sources

Prokaryotic defense systems: Diversity and evolutionary adaptation

mLife, Volume 5, Issue 1, Page 3-16, February 2026.
Abstract Bacteriophages and archaeal viruses are the most abundant biological entities on Earth. Through a long‐standing co‐evolutionary arms race, they have driven the emergence of a diverse repertoire of prokaryotic defense systems. This review summarizes these systems, highlighting their diverse antiviral mechanisms across distinct stages of viral ...
Changjialian Yang, Luyao Gong, Jing Guo, Hua Xiang   +3 more
wiley   +1 more source