Results 61 to 70 of about 12,448,100 (233)

5-Hydroxymethylcytosine discriminates between parathyroid adenoma and carcinoma [PDF]

Clinical Epigenetics, 2016
Primary hyperparathyroidism is characterized by enlarged parathyroid glands due to an adenoma (80-85 %) or multiglandular disease (~15 %) causing hypersecretion of parathyroid hormone (PTH) and generally hypercalcemia. Parathyroid cancer is rare (
Barazeghi, E, Gill, AJ, Sidhu, S, Norlen, O, Dina, R, Palazzo, FF, Hellman, P, Stalberg, P, Westin, G   +8 more
openaire   +5 more sources

Altering 5-hydroxymethylcytosine modification impacts ischemic brain injury [PDF]

Human Molecular Genetics, 2015
Epigenetic modifications such as cytosine methylation and histone modification are linked to the pathology of ischemic brain injury. Recent research has implicated 5-hydroxymethylcytosine (5hmC), a DNA base derived from 5-methylcytosine (5mC) via oxidation by ten-eleven translocation (Tet) enzymes, in DNA methylation-related plasticity.
Zhigang, Miao, Yuquan, He, Ning, Xin, Miao, Sun, Li, Chen, Li, Lin, Jizhen, Li, Jiming, Kong, Peng, Jin, Xingshun, Xu   +9 more
openaire   +2 more sources

Cell cycle-dependent turnover of 5-hydroxymethyl cytosine in mouse embryonic stem cells.

PLoS ONE, 2013
Hydroxymethylcytosine in the genome is reported to be an intermediate of demethylation. In the present study, we demonstrated that maintenance methyltransferase Dnmt1 scarcely catalyzed hemi-hydroxymethylated DNA and that the hemi-hydroxymethylated DNA ...
Junji Otani, Hironobu Kimura, Jafar Sharif, Takaho A Endo, Yuichi Mishima, Toru Kawakami, Haruhiko Koseki, Masahiro Shirakawa, Isao Suetake, Shoji Tajima   +9 more
doaj   +1 more source

{BiQ} Analyzer {HiMod}: An Interactive Software Tool for High-throughput Locus-specific Analysis of 5-Methylcytosine and its Oxidized Derivatives [PDF]

, 2014
Recent data suggest important biological roles for oxidative modifications of methylated cytosines, specifically hydroxymethylation, formylation and carboxylation. Several assays are now available for profiling these DNA modifications genome-wide as well
Becker, D., Bock, C., Ebert, P., Lengauer, T., Lutsik, P., Walter, J.   +5 more
core   +2 more sources

Tet-Mediated Formation of 5-Hydroxymethylcytosine in RNA [PDF]

Journal of the American Chemical Society, 2014
Oxidation of 5-methylcytosine in DNA by ten-eleven translocation (Tet) family of enzymes has been demonstrated to play a significant role in epigenetic regulation in mammals. We found that Tet enzymes also possess the activity of catalyzing the formation of 5-hydroxymethylcytidine (5-hmrC) in RNA in vitro.
Fu, Lijuan, Guerrero, Candace R., Zhong, Na, Amato, Nicholas J., Liu, Yunhua, Liu, Shuo, Cai, Qian, Ji, Debin, Jin, Seung-Gi, Niedernhofer, Laura J., Pfeifer, Gerd P., Xu, Guo-Liang, Wang, Yinsheng   +12 more
openaire   +2 more sources

High-throughput sequencing offers new insights into 5-hydroxymethylcytosine

Biomolecular Concepts, 2016
Chemical modifications of DNA comprise epigenetic mechanisms that contribute to the maintenance of cellular activities and memory. Although the function of 5-methylcytosine (5-mC) has been extensively studied, little is known about the function(s) of ...
Pang Alina P.S., Sugai Christopher, Maunakea Alika K.   +2 more
doaj   +1 more source

Aberrant gene-specific DNA methylation signature analysis in cervical cancer

Tumor Biology, 2017
Multicomponent molecular modifications such as DNA methylation may offer sensitive and specific cervical intraepithelial neoplasia and cervical cancer biomarkers.
Samatha Bhat, Shama Prasada Kabekkodu, Vinay Koshy Varghese, Sanjiban Chakrabarty, Sandeep P Mallya, Harish Rotti, Deeksha Pandey, Pralhad Kushtagi, Kapaettu Satyamoorthy   +8 more
doaj   +1 more source

DNA methylation dynamics in aging: How far are we from understanding the mechanisms? [PDF]

, 2018
DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered.Here we discuss the current knowledge ...
Caiafa, Paola, Ciccarone, Fabio, Tagliatesta, Stefano, Zampieri, Michele   +3 more
core   +1 more source

5‐Methylcytosine Analysis of miRNAs in Minimal Change Disease

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Minimal change disease (MCD) is a glomerular disorder, which is the most common cause of nephrotic syndrome in children. Additionally, the prevalence of MCD in adults has been increasing in recent years. During protein synthesis, noncoding RNAs can be regulated through a variety of modifications, which helps preserve biological diversity and ...
Huiyi Zeng, Dandan Li, Yunyi Li, Chen Yun, Xinzhou Zhang, Wenyu Gong, Mengyun Xiao, Haitao Li, Zhipeng Zeng, Ruqi Tan, Yishen Yang, Shaodong Luan, Yong Dai, Lianghong Yin, Donge Tang   +14 more
wiley   +1 more source

Metabotropic glutamate 2/3 receptors and epigenetic modifications in psychotic disorders: a review [PDF]

, 2016
Schizophrenia and Bipolar Disorder are chronic psychiatric disorders, both considered as "major psychosis"; they are thought to share some pathogenetic factors involving a dysfunctional gene x environment interaction.
Grayson, Danis R, Guidotti, Alessandro, MATRISCIANO, FRANCESCO, NICOLETTI, Ferdinando, PANACCIONE, ISABELLA   +4 more
core   +2 more sources