Results 81 to 90 of about 12,448,100 (233)

Russian wheat aphid: a model for genomic plasticity and a challenge to breeders

Insect Science, EarlyView.
Invasive foundress finds suitable habitat and reproduces through pathogenesis. Wingless females produce life offspring quickly, which leads to high population densities. High population densities result in competition, which may induce epigenetic changes and wing development for dispersal.
Astrid Jankielsohn, Vicky L. Tolmay, Marlon‐Schylor Luke le Roux, Lintle Mohase, Mpho S. Mafa, Vittorio F. Nicolis, Eduard Venter, Nicolaas Francois Visser Burger, Anna‐Maria Botha   +8 more
wiley   +1 more source

Analysis of TET expression/activity and 5mC oxidation during normal and malignant germ cell development.

PLoS ONE, 2013
During mammalian development the fertilized zygote and primordial germ cells lose their DNA methylation within one cell cycle leading to the concept of active DNA demethylation.
Daniel Nettersheim, Lukas C Heukamp, Florian Fronhoffs, Marc J Grewe, Natalie Haas, Anke Waha, Friedemann Honecker, Andreas Waha, Glen Kristiansen, Hubert Schorle   +9 more
doaj   +1 more source

5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages

Cell Research, 2017
5-Hydroxymethylcytosine (5hmC) is an important mammalian DNA epigenetic modification that has been linked to gene regulation and cancer pathogenesis. Here we explored the diagnostic potential of 5hmC in circulating cell-free DNA (cfDNA) using a sensitive
Chun-Xiao Song, S. Yin, Li Ma, A. Wheeler, Yu Chen, Yan Zhang, B. Liu, Jun-jie Xiong, Weihan Zhang, Jiankun Hu, Zongguang Zhou, Biao Dong, Zhiqi Tian, S. Jeffrey, M. Chua, S. So, Weimin Li, Yuquan Wei, Jiajie Diao, D. Xie, S. Quake   +20 more
semanticscholar   +1 more source

Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone‐Related Diseases

Cell Proliferation, EarlyView.
Engineered BMSCs and vesicles enhance therapy effects for bone diseases via multi‐strategic approaches. ABSTRACT Bone‐related diseases (e.g., osteoporosis, osteoarthritis and fractures) exhibit a rising global incidence, imposing significant burdens on both quality of life and healthcare systems.
Xuemei Long, Dan Tan, Qianke Tao, Qiaonan Ye, Luwen Ye, Qing Li, Jingang Xiao   +6 more
wiley   +1 more source

TET enzymes augment activation-induced deaminase (AID) expression via 5-hydroxymethylcytosine modifications at the Aicda superenhancer

Science immunology, 2019
TET enzymes promote B cell responses by augmenting Aicda expression via DNA modification at cis elements in the Aicda locus. Epigenetic enablers of B cell activation Initiation of immunoglobulin class switching and somatic hypermutation during B cell ...
C. Lio, V. Shukla, Daniela Samaniego-Castruita, Edahí González-Avalos, Abhijit Chakraborty, Xiaojing Yue, D. Schatz, F. Ay, A. Rao   +8 more
semanticscholar   +1 more source

Selective Capture of 5-hydroxymethylcytosine from Genomic DNA [PDF]

Journal of Visualized Experiments, 2012
5-methylcytosine (5-mC) constitutes ~2-8% of the total cytosines in human genomic DNA and impacts a broad range of biological functions, including gene expression, maintenance of genome integrity, parental imprinting, X-chromosome inactivation, regulation of development, aging, and cancer(1).
Yujing, Li, Chun-Xiao, Song, Chuan, He, Peng, Jin   +3 more
openaire   +2 more sources

Circulating Microbial Metabolites Predict Tumor Relapse and Chemotherapy Efficacy in Nasopharyngeal Carcinoma

MedComm, Volume 7, Issue 4, April 2026.
ABSTRACT The value of microbial metabolites in prognosis and treatment response prediction in patients with nasopharyngeal carcinoma (NPC) remains unclear. Here, through the untargeted metabolomic analysis of plasma in 48 paired NPC patients with or without tumor relapse, we identified distinct circulating metabolite atlases between NPC patients with ...
Jun‐Yan Li, Yao Yao, Xi‐Rong Tan, Nan Si, Wei Jiang, Ying‐Qi Lu, Jia‐Hao Dai, Tian‐Tian Yu, Hao‐Cheng Hu, Yu‐Fei Duan, Sen‐Yu Feng, Sai‐Wei Huang, Ye‐Lin Liang, Sha Gong, Na Liu, Yu‐Min Hu, Ying‐Qing Li   +16 more
wiley   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Induction of Radiata Pine Somatic Embryogenesis at High Temperatures Provokes a Long-Term Decrease in DNA Methylation/Hydroxymethylation and Differential Expression of Stress-Related Genes

Plants, 2020
Based on the hypothesis that embryo development is a crucial stage for the formation of stable epigenetic marks that could modulate the behaviour of the resulting plants, in this study, radiata pine somatic embryogenesis was induced at high temperatures (
Ander Castander-Olarieta, Cátia Pereira, Ester Sales, Mónica Meijón, Isabel Arrillaga, María Jesús Cañal, Tomás Goicoa, María Dolores Ugarte, Paloma Moncaleán, Itziar A. Montalbán   +9 more
doaj   +1 more source

Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain. [PDF]

, 2018
Restoring adult stem cell function provides an exciting approach for rejuvenating the aging brain. However, molecular mechanisms mediating neurogenic rejuvenation remain elusive.
Bieri, Gregor, Gontier, Geraldine, Iyer, Manasi, Ramalho-Santos, Miguel, Shea, Jeremy M, Villeda, Saul A, Wheatley, Elizabeth G   +6 more
core   +2 more sources