Results 111 to 120 of about 44,016 (219)

Characterisation of Antisense Oligonucleotides by Ion‐Pair Reversed‐Phase UHPLC‐HRMS: Method development using Design of Experiments

Journal of Mass Spectrometry, Volume 61, Issue 4, April 2026.
ABSTRACT The quality control of therapeutic antisense oligonucleotides (ASOs) poses significant analytical challenges due to the complexity of their synthesis and degradation processes and the need to ensure the safety and efficacy of active pharmaceutical ingredients (APIs).
Antonio Triolo, Fabiana Tavani, Prisca Barnini, Sandra Furlanetto, Serena Orlandini   +4 more
wiley   +1 more source

Tet proteins: on track towards DNA demethylation?

Biomolecular Concepts, 2012
Dynamic DNA methylation is a prerequisite for many developmental processes and maintenance of cellular integrity. In mammals however, mechanisms of active DNA demethylation have for long been elusive.
Véron Nathalie
doaj   +1 more source

NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs

Nucleic Acids Research, 2019
Abstract Expression of human mitochondrial DNA is indispensable for proper function of the oxidative phosphorylation machinery. The mitochondrial genome encodes 22 tRNAs, 2 rRNAs and 11 mRNAs and their post-transcriptional modification constitutes one of the key regulatory steps during mitochondrial gene expression.
Van Haute, Lindsey, Lee, Song-Yi, McCann, Beverly J, Powell, Christopher A, Bansal, Dhiru, Vasiliauskaitė, Lina, Garone, Caterina, Shin, Sanghee, Kim, Jong-Seo, Frye, Michaela, Gleeson, Joseph G, Miska, Eric A, Rhee, Hyun-Woo, Minczuk, Michal   +13 more
openaire   +2 more sources

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Analysis of TET expression/activity and 5mC oxidation during normal and malignant germ cell development.

PLoS ONE, 2013
During mammalian development the fertilized zygote and primordial germ cells lose their DNA methylation within one cell cycle leading to the concept of active DNA demethylation.
Daniel Nettersheim, Lukas C Heukamp, Florian Fronhoffs, Marc J Grewe, Natalie Haas, Anke Waha, Friedemann Honecker, Andreas Waha, Glen Kristiansen, Hubert Schorle   +9 more
doaj   +1 more source

Integration of epigenetics into ecotoxicology: insights and fundamental research needs

Biological Reviews, Volume 101, Issue 2, Page 826-847, April 2026.
ABSTRACT Epigenetics refers to heritable changes in genome function that occur without direct alterations to the DNA sequence. A multitude of environmental contaminants can influence the epigenetic marks of a genome. Changes of epigenetic marks including DNA methylation, histone modifications, and non‐coding RNAs can induce alterations at the gene ...
Albano Pinto, Jana Asselman, Patrícia Pereira, Joana Luísa Pereira   +3 more
wiley   +1 more source

Epigenetic Modulation of the ACE System Underlies the Slow Aerobic Muscle Phenotype and Metabolic Exercise Response

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Weekly moderate‐to‐vigorous activity (≈6 h) induced a marked increase in ACE promoter methylation in exercised knee‐extensor muscle. In combination with the ACE I/D genotype, ACE methylation contributed to ACE gene activity regulation in ways aligning with the slow‐twitch, aerobic muscle phenotype and its metabolic response to endurance exercise ...
Flück Martin, Benedikt Gasser, Giraud Marie‐Noëlle   +2 more
wiley   +1 more source

NSUN5 promotes cholangiocarcinoma progression by enhancing GLS mRNA stabilization

Journal of Cancer Research and Clinical Oncology
Background NSUN5, also known as NOP2/Sun domain 5, is a pivotal RNA methyltransferase that catalyzes the formation of 5-methylcytosine (m5C). Cuproptosis, induced by elevated copper concentrations, is under investigation as a potential therapeutic ...
Ming Shu, Kunpeng Guo, Yikai Huang, Weishan Wang   +3 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, Volume 20, Issue 3, Page 709-726, March 2026.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

The versatile thymine DNA‐glycosylase: a comparative characterization of the human, Drosophila and fission yeast orthologs [PDF]

, 2017
Human thymine‐DNA glycosylase (TDG) is well known to excise thymine and uracil from G·T and G·U mismatches, respectively, and was therefore proposed to play a central role in the cellular defense against genetic mutation through spontaneous deamination ...
Bentele, Marc, Hardeland, Ulrike, Jiricny, Josef, Schär, Primo   +3 more
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