Results 131 to 140 of about 44,016 (219)
MedComm – Oncology, Volume 5, Issue 1, March 2026.Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang +7 more
wiley +1 more source
The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance
MedComm – Oncology, Volume 5, Issue 1, March 2026.One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang +3 more
wiley +1 more source
Neuroprotection, Volume 4, Issue 1, Page 14-29, March 2026.Three‐panel graphical abstract showing the Lifelong Neurobiological Trajectory framework for Parkinson's disease: (1) Vulnerability pathway (top, red) showing how early adversity → epigenetic dysregulation, neuroinflammation, and mitochondrial dysfunction → ↑ PD risk; (2) Lifespan timeline (middle, purple) spanning prenatal/infancy → childhood ...
Ayodeji Johnson Ajibare +2 more
wiley +1 more source
DNA methylation meets lineage tracing: History, recent progress, and future directions
Quantitative Biology, Volume 14, Issue 1, March 2026.Abstract Lineage tracing techniques have been developed rapidly in the past decades by employing new genetic engineering tools. However, due to their invasive nature, these are difficult to apply to humans. Although endogenous DNA mutations can be used for in vivo lineage tracing in humans, their extremely low mutation rate presents substantial ...
Ruijiang Fu +2 more
wiley +1 more source
Quantification of cytosine modifications in the aged mouse brain
Neuropsychopharmacology ReportsQuantifying cytosine modifications in various brain regions provides important insights into the gene expression regulation and pathophysiology of neuropsychiatric disorders.
Hiroko Sugawara +7 more
doaj +1 more source
Ageing Through the Looking‐Glass: The Different Flavours of Clonal Haematopoiesis
Aging Cell, Volume 25, Issue 3, March 2026.Different forms of CH share common germline and environmental risk factors and have overlapping prevalence and disease associations, suggesting common underlying ageing processes. We explore intersections of different forms of CH, clinical implications of these, and how this enhances our understanding of the biology of ageing.
Jasmine Singh +4 more
wiley +1 more source
Unveiling the potential impact of RNA m5C methyltransferases NSUN2 and NSUN6 on cellular aging
Frontiers in GeneticsNSUN2 and NSUN6, two family members of NOL1/NSUN protein, are mainly responsible for catalyzing the formation of 5-methylcytosine (m5C) in RNA and highly involved in the physiological and pathological processes of many diseases.
Jiale Zhou +7 more
doaj +1 more source
Hypoxia Promotes an Adrenergic to Mesenchymal Transcriptional Program Transition in Neuroblastoma
Clinical and Translational Science, Volume 19, Issue 3, March 2026.ABSTRACT Adrenergic (ADRN) neuroblastoma cells have a paradoxical increase in TET1 expression and 5‐hydroxymethylcytosine (5‐hmC) deposition in hypoxia. However, the effect of hypoxia on the mesenchymal (MES) lineage remains less well understood. To identify lineage specific hypoxia responses, we evaluated 5‐hmC and RNA expression in a panel of ADRN ...
Gepoliano S. Chaves +11 more
wiley +1 more source
EpigeneticsThe Nile tilapia (Oreochromis niloticus) exhibits a strong metabolic response to dietary carbohydrates (CHO). Short-term refeeding after fasting with a high-carbohydrate (HC) diet has been shown to modulate CHO metabolism, but the role of epigenetic ...
Sirijanya Thongchaitriwat +6 more
doaj +1 more source