Results 71 to 80 of about 44,016 (219)

Genome-wide analysis reveals TET-and TDG-mediated 5-methylcytosine oxidation dynamics [PDF]

, 2013
Stem Cell and Regenerative ...
Diep, Dinh, D’Alessio, Ana C, Fung, Alan, Shen, Li, Wu, Hao, Zhang, Kun, Zhang, Yi   +6 more
core   +1 more source

Gut microbiome‐derived metabolites show promise in cancer research and therapy

Interdisciplinary Medicine, EarlyView.
The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du   +4 more
wiley   +1 more source

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

The Methylation Game: Epigenetic and Epitranscriptomic Dynamics of 5-Methylcytosine

Frontiers in Cell and Developmental Biology, 2022
DNA and RNA methylation dynamics have been linked to a variety of cellular processes such as development, differentiation, and the maintenance of genome integrity.
Adele Alagia, Monika Gullerova
doaj   +1 more source

TET3‐Mediated m5C Modification of CCAT2 Accelerates Cardiac Microvascular Endothelial Cell Damage in Acute Coronary Syndrome

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Acute coronary syndrome (ACS) is a clinical syndrome involving myocardial ischemia. This study aimed to elucidate the mechanism of TET3 in ACS‐induced CMEC damage, thereby identifying a new target for ACS treatment. The expression of TET3 in ACS patients and healthy subjects was analyzed.
Jun‐Cheng Liu, Wen‐Juan Wang, Ting‐Ting Zhang, Qi‐Chong Yang, Haliminai Dilimulati, Song‐Tao An   +5 more
wiley   +1 more source

Direct Sensing of 5‐Methylcytosine by Polymerase Chain Reaction [PDF]

Angewandte Chemie International Edition, 2014
AbstractThe epigenetic control of genes by the methylation of cytosine resulting in 5‐methylcytosine (5mC) has fundamental implications for human development and disease. Analysis of alterations in DNA methylation patterns is an emerging tool for cancer diagnostics and prognostics.
Aschenbrenner, Joos, Drum, Matthias, Topal, Hüsnü, Wieland, Markus, Marx, Andreas   +4 more
openaire   +3 more sources

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, EarlyView.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

Detection of dioxin-induced demethylation of mouse Cyp1a1 gene promoter by a new labeling method for short DNA fragments possessing 5'-methylcytosine at the end

Genes and Environment, 2018
Environmental factors stimulate alteration of DNA methylation level. Investigation of the genome-wide DNA methylation status is important for environmental health studies.
Hisaka Kurita, Toshiki Aiba, Toshiyuki Saito, Seiichiroh Ohsako   +3 more
doaj   +1 more source

Intronic Non-CG DNA hydroxymethylation and alternative mRNA splicing in honey bees [PDF]

, 2013
Background Previous whole-genome shotgun bisulfite sequencing experiments showed that DNA cytosine methylation in the honey bee (Apis mellifera) is almost exclusively at CG dinucleotides in exons.
Bollig-Fischer, Aliccia, Cao, Xiaoyi, Chen, Chieh-Chun, Cingolani, Pablo, Coon, Melissa, Garfinkel, Mark D, Huang, Yun, Hudson, Matthew E, Khetani, Radhika S, Land, Susan, Robinson, Gene E, Ruden, Douglas M, Sammak, Alya\u27a, Zhong, Sheng   +13 more
core   +2 more sources

African Trypanosomes Contain 5-Methylcytosine in Nuclear DNA [PDF]

Eukaryotic Cell, 2008
ABSTRACT It is currently unclear if there are modified DNA bases in Trypanosoma brucei other than J-base. We identify herein a cytosine-5 DNA methyltransferase gene and report the presence and location of 5-methylcytosine in genomic DNA.
Kevin T, Militello, Ping, Wang, Sangeeta K, Jayakar, Rebecca L, Pietrasik, Christopher D, Dupont, Kristi, Dodd, Anthony M, King, Paul R, Valenti   +7 more
openaire   +2 more sources