Results 31 to 40 of about 32,355 (207)
Journal of Pharmacological Sciences, 2006 DJ-1 has multiple functions and its dysfunction may be linked to the onset of familial Parkinson’s disease PARK7. However, the function and distribution of DJ-1 is unclear.
Takashi Yanagida +7 more
doaj +1 more source
N-acetylcysteine protects against motor, optomotor and morphological deficits induced by 6-OHDA in zebrafish larvae [PDF]
PeerJ, 2018 Background Parkinson’s disease (PD) is the second most common neurodegenerative disorder. In addition to its highly debilitating motor symptoms, non-motor symptoms may precede their motor counterparts by many years, which may characterize a prodromal ...
Radharani Benvenutti +7 more
doaj +2 more sources
CIB1 protects against MPTP-induced neurotoxicity through inhibiting ASK1. [PDF]
, 2017 Calcium and integrin binding protein 1 (CIB1) is a calcium-binding protein that was initially identified as a binding partner of platelet integrin αIIb. Although CIB1 has been shown to interact with multiple proteins, its biological function in the brain
Choi, Eui-Ju +8 more
core +4 more sources
Baicalein Prevents 6-Hydroxydopamine-Induced Dopaminergic Dysfunction and Lipid Peroxidation in Mice
Journal of Pharmacological Sciences, 2005 The effects of baicalein on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity were evaluated. Intracerebroventricularly (i.c.v.) injection of 6-OHDA was done to young mice. Baicalein was administered intraperitoneally 30 min before and 90 min after i.c.v.
Heh-In Im +5 more
doaj +1 more source
The unilateral nigral lesion induces dramatic bilateral modification on rat brain monoamine neurochemistry [PDF]
, 2009 6-Hydroxydopamine (6-OHDA) is a neurotoxic compound commonly used to induce dopamine (DA) depletion in the nigrostriatal system, mimicking Parkinson's disease (PD) in animals.
Beal +41 more
core +1 more source
The Effect of Chronic Administration of Buspirone on 6-Hydroxydopamine-Induced Catalepsy in Rats [PDF]
Advanced Pharmaceutical Bulletin, 2012 Purpose: Several evidences show that serotonergic neurons play a role in the regulation of movements executed by the basal ganglia. Recently we have reported that single dose of buspirone improved 6-hydroxydopamine (6-OHDA) and haloperidol-induced ...
Hamdolah Sharifi +2 more
doaj
Reduced proliferation in the adult mouse subventricular zone increases survival of olfactory bulb interneurons. [PDF]
PLoS ONE, 2012 Neurogenesis in the adult brain is largely restricted to the subependymal zone (SVZ) of the lateral ventricle, olfactory bulb (OB) and the dentate subgranular zone, and survival of adult-born cells in the OB is influenced by factors including sensory ...
Yi Sui, Malcolm K Horne, Davor Stanić
doaj +1 more source
Advanced Science, EarlyView.Wang et al reveal that in the olfactory system, the selective impairment of gamma‐driven Barcode features underlying early olfactory deficits, while the selective impairment of theta‐driven Barcode features underlying later cognitive deficits, further establishing cross‐network gamma oscillations in the early stage as a biomarker of later cognitive ...
Shuaishuai Wang +13 more
wiley +1 more source
6‐Hydroxydopamine induces brain vascular endothelial inflammation [PDF]
IUBMB Life, 2017 AbstractDisruption of the blood‐brain barrier associated with endothelial dysfunction is an important hallmark of Parkinson's disease (PD). 6‐Hydroxydopamine (6‐OHDA) is a synthetic dopamine derivate often used to model PD as it results in retrograde degeneration of striatal dopaminergic (DA) terminals.
Qizhi Fu +4 more
openaire +2 more sources
Advanced Science, EarlyView.Netrin‐1 expression is upregulated in hepatic stellate cells (HSCs) during metabolic dysfunction–associated steatohepatitis and injury‐mediated liver fibrosis. Secreted Netrin‐1 establishes an autocrine positive feedback loop by binding to UNC5B receptors on HSCs.
Jiahui Zhao +8 more
wiley +1 more source