Results 1 to 10 of about 24,769 (191)

Preparation and characterization of 6-mercaptopurine-coated magnetite nanoparticles as a drug delivery system [PDF]

Drug Design, Development and Therapy, 2013
Dena Dorniani,1 Mohd Zobir bin Hussein,1 Aminu Umar Kura,2 Sharida Fakurazi,2 Abdul Halim Shaari,3 Zalinah Ahmad4 1Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, 2Vaccines and Immunotherapeutics Laboratory ...
Dorniani D, Hussein MZ, Kura AU, Fakurazi S, Shaari AH, Ahmad Z   +5 more
doaj   +3 more sources

Antiviral Potential of Azathioprine and Its Derivative 6- Mercaptopurine: A Narrative Literature Review [PDF]

Pharmaceuticals
The use of azathioprine (AZA) in human medicine dates back to research conducted in 1975 that led to the development of several drugs, including 6-mercaptopurine.
Carolina Rios-Usuga, Marlen Martinez-Gutierrez, Julian Ruiz-Saenz   +2 more
doaj   +2 more sources

Toxicity evaluation of 6-mercaptopurine-Chitosan nanoparticles in rats [PDF]

Saudi Pharmaceutical Journal, 2020
Background: The 6-mercaptopurine (6-MP) is an effective immunosuppressant and anti-cancer drug. However, the usage of 6-MP is limited due to its well-known side effects, such as myelotoxicity and hepato-renal toxicity.
Prem Kumar Govindappa, Darukeshwara Joladarashi, Raghavendra Lakshmana Shetty Hallur, Jagadeesh S. Sanganal, Ayyalasomayajula Ratna Phani   +4 more
doaj   +2 more sources

Electrochemical sensing platform for simultaneous detection of 6-mercaptopurine and 6-thioguanine using RGO-Cu2O/Fe2O3 modified screen-printed graphite electrode

Journal of Electrochemical Science and Engineering, 2021
A sensitive electrochemical sensor was developed using reduced graphene oxide RGO-Cu2O/Fe2O3 nanocomposite for 6-mercaptopurine detection based on a facile fabrication method.
Fatemeh Irannezhad, Jamileh Seyed-Yazdi, Seyedeh Hoda Hekmatara   +2 more
doaj   +1 more source

gene variants and thiopurine-induced leukopenia in patients with inflammatory bowel disease [PDF]

Intestinal Research, 2020
Thiopurine has been used to maintain remission and to reduce antidrug antibody formation in monoclonal antibody therapy in patients with inflammatory bowel disease (IBD). The use of thiopurine is limited by side effects such as leukopenia.
Katsuyoshi Matsuoka
doaj   +1 more source

Effects of 6– Mercaptopurine on Salivary Glands in Rabbit [PDF]

Al-Rafidain Dental Journal, 2012
To study the effect of 6 – Mercaptopurine on salivary glands of rabbits. Materials and Methods: This study was carried out on 6 young rabbits of both sexes, aged 2 – 3 months, and weighing 1.250-1.350 Kg.
Alhan D Al–Moula, Fayhaa A Al-Mashhadane, Jawna’a K Mammdoh   +2 more
doaj   +1 more source

A Comprehensive Approach to Compatibility Testing Using Chromatographic, Thermal and Spectroscopic Techniques: Evaluation of Potential for a Monolayer Fixed-Dose Combination of 6-Mercaptopurine and Folic Acid

Pharmaceuticals, 2021
In this work, a systematical compatibility investigation of 6-mercaptopurine and folic acid, two commonly used medications in the treatment of inflammatory bowel disease, for the needs of a fixed-dose combination development strategy is shown.
Edvin Brusač, Mario-Livio Jeličić, Matija Cvetnić, Daniela Amidžić Klarić, Biljana Nigović, Ana Mornar   +5 more
doaj   +1 more source

Chromatographic Method for Determining 6‑Mercaptopurine in Skin Permeation Assays for Assessing Cutaneous Exposure Risk [PDF]

ACS Omega
Gabriel S. Oliveira, Ana Luiza Lima, Idejan P. Gross, Livia Sa-Barreto, Patrícia Medeiros-Souza, Tais Gratieri, Guilherme M. Gelfuso, Marcilio Cunha-Filho   +7 more
doaj   +2 more sources

Allele-specific polymerase chain reaction can determine the diplotype of NUDT15 variants in patients with childhood acute lymphoblastic Leukemia

Scientific Reports, 2023
Mercaptopurine intolerance is an adverse effect of mercaptopurine administration in pediatric patients with acute lymphoblastic leukemia (ALL). NUDT15 variants have emerged as major determinants of mercaptopurine intolerance, especially in the Asian ...
Chih-Hsiang Yu, Ya-Hsuan Chang, Der-Shiun Wang, Shiann-Tarng Jou, Chien-Yu Lin, Kai-Hsin Lin, Meng-Yao Lu, Kang-Hsi Wu, Chao-Neng Cheng, Hsiu-Hao Chang, Shu-Wei Chou, Min-Yu Su, Yu-Ling Ni, Pei-Yuan Xu, Dong-Tsamn Lin, Shu-Wha Lin, Hsuan-Yu Chen, Yung-Li Yang   +17 more
doaj   +1 more source

Impact of the homozygous mutation in Nudix hydrolase 15 on myelosuppression with 6-mercaptopurine in a European girl with acute lymphoblastic leukemia: a case report

Ars Pharmaceutica, 2023
A 6-year-old girl diagnosed with intermediate-risk acute lymphoblastic leukemia (ALL) presented with severe myelotoxicity and multiple infections during phase IB induction treatment with 6-mercaptopurine (6-MP).
Laura Elena Pineda-Lancheros, María del Mar Sánchez-Suárez, Luciana María Marangoni-Iglecias, Ricardo García-Fumero, Susana Rojo-Tolosa, Noelia Moreno-Toro   +5 more
doaj   +1 more source