Results 111 to 120 of about 8,386,191 (259)

Genetic Polymorphism of Thiopurine S-Methyltransferase in Children with Acute Lymphoblastic Leukemia

Pakistan Journal of Medicine and Dentistry
Background: 6-Mercaptopurine (6-MP), a widely used anti-metabolite for the maintenance phase of childhood acute lymphoblastic leukemia (ALL), has been observed to cause myelotoxicity due to genetic polymorphism of thiopurine methyl transferase (TPMT ...
Afrina Raza, Shamil Ashraf, Soofia Nigar, Itimad Abdelsalam Mohamed Ayed   +3 more
doaj   +1 more source

Quantification of 6-Mercaptopurine and Its Metabolites in Patients with Acute Lympoblastic Leukemia Using Dried Blood Spots and UPLC-MS/MS

Scientia Pharmaceutica, 2018
This research aimed to quantitatively bioanalyze 6-mercaptopurine (6-MP), 6-methylmercaptopurine (6-MMP), and 6-thioguanosine-5′-monophosphate (6-TGMP) in dried blood spots (DBS) prepared from a small volume of acute lymphoblastic leukemia (ALL ...
Supandi Supandi, Yahdiana Harahap, Harmita Harmita, Rizka Andalusia   +3 more
doaj   +1 more source

Comparative risk of serious infection among biologic therapies for inflammatory bowel disease in pediatric patients: A target trial emulation

Journal of Pediatric Gastroenterology and Nutrition, Volume 82, Issue 2, Page 503-507, February 2026.
Serena Yun‐Chen Tsai, Ashwin N. Ananthakrishnan, Harland S. Winter, Kevin Sheng‐Kai Ma   +3 more
wiley   +1 more source

Azathioprine and 6-Mercaptopurine use in the Swiss IBD cohort : adverse effects, causes of discontinuation and risk of "flares" according to 6-TG levels [PDF]

, 2015
Background: To characterize and analyze in the Swiss IBD Cohort: a) reported Azathioprine (AZA) and 6-Mercaptopurine (6-MP) adverse effects (AE), b) causes of discontinuation and c) response to therapy according to gastroenterologists' clinical judgment,
Fournier, N., Lavrek, D., Mottet, C., Muller, D., Pittet, V.   +4 more
core  

Double Hydroxyl Salt as Smart Biocompatible pH-Responsive Carrier for 6-Mercaptopurine. [PDF]

Cancers (Basel), 2023
Sandomierski M, Jakubowski M, Ratajczak M, Patalas A, Gaweł-Bęben K, Lechwar P, Voelkel A.   +6 more
europepmc   +1 more source

Thiopurine S-methyltransferase polymorphisms in acute lymphoblastic leukemia, inflammatory bowel disease and autoimmune disorders: influence on treatment response

Pharmacogenomics and Personalized Medicine, 2017
Rachid Abaji,1 Maja Krajinovic2 1Department of Pharmacology, 2Departments of Pediatrics and Pharmacology, CHU Sainte-Justine Research Center, University of Montreal, Montreal, QC, Canada Abstract: The thiopurine S-methyltransferase (TPMT) gene encodes ...
Abaji R, Krajinovic M
doaj  

Pharmacogenetics of 6-mercaptopurine in a black Zimbabwean cohort treated for acute lymphoblastic leukaemia. [PDF]

Pharmacogenomics, 2023
Chikondowa P, Munkombwe D, Chikwambi Z, Kuona P, Masimirembwa C.   +4 more
europepmc   +1 more source

6-mercaptopurine Metabolites as Predictors of Neutropenia and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia [PDF]

Journal of Pediatrics Review
Background: 6-Mercaptopurine (6-MP) is used to treat childhood acute lymphoblastic leukemia (ALL). The concentrations of 6-MP metabolites in red blood cells (RBCs), specifically 6-thioguanine (6-TG) and 6-methyl mercaptopurine nucleotides (6-MMP), are ...
Ebrahim Salehifar, Omid Abed Khojasteh, Seyed Jalal Hosseinimehr, Hossein Karami, Mohammad Naderi Sorki, Hadi Darvish-Khezri, Kimia Karami   +6 more
doaj  

An unusual case of intertrigo in an adult caused by purely cutaneous Langerhans cell histiocytosis [PDF]

, 2016
We report a case of persistent intertrigo in an adult, eventually diagnosed as cutaneous Langerhans cell histiocytosis (LCH). It is known that LCH has a predilection for intertriginous areas, however purely cutaneous disease as in our case, is uncommon ...
Baldacchino, Godfrey, Betts, Alexandra, Boffa, Michael J., Gatt, Alex   +3 more
core  

Immunomodulatory therapy in paediatric inflammatory bowel disease

Zdravniški Vestnik, 2013
Immunomodulatory drugs are indispensable in the treatment of children with both Crohn’s disease and ulcerative colitis, especially in maintaining remission.
András Arató
doaj