Results 11 to 20 of about 8,386,191 (259)

Dietary polyphenols influence antimetabolite agents: methotrexate, 6-mercaptopurine and 5-fluorouracil in leukemia cell lines [PDF]

OncoTarget, 2017
Polyphenols have been previously shown to sensitize leukemia cell lines to topoisomerase inhibitors. Here, we assess the effects of five polyphenols when used alone and in combination with antimetabolites: methotrexate, 6-mercaptopurine and 5 ...
Abels, Chandra, Cidlowski, D'Arca, Day, Domenicotti, Estrela, Hung, Jacqz-Aigrain, Jia, Jordan-Mahy, Jordan-Mahy, Jordan-Mahy, Jordan-Mahy, Juillerat-Jeanneret, Krishnan, Ledwani, Lee, Lee, Li, Liang, Locasale, Lou, Manne, Mumper, Ni, Ong, Orlowski, Ramos, Rauko, Rodríguez-López, Scalbert, Schini-Kerth, Schmiegelow, Schönthal, Sharma, Singh, Sujatha, Tsao, Veit, Weng, Weng   +41 more
core   +2 more sources

Variants in TPMT, ITPA, ABCC4 and ABCB1 genes as predictors of 6-mercaptopurine induced toxicity in children with acute lymphoblastic leukemia [PDF]

Journal of Medical Biochemistry, 2018
Background: Acute lymphoblastic leukemia is the most common childhood malignancy. Optimal use of anti leukemic drugs has led to less toxicity and adverse reactions, and a higher survival rate. Thiopurine drugs, including 6-mercaptopurine, are mostly used
Milošević Goran, Kotur Nikola, Krstovski Nada, Lazić Jelena, Zukić Branka, Stanković Biljana, Janić Dragana, Katsila Theodora, Patrinos George P., Pavlović Sonja, Dokmanović Lidija   +10 more
doaj   +2 more sources

Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase-catalyzed xanthine and 6-mercaptopurine oxidation. [PDF]

J Sci Food Agric
Abstract BACKGROUND Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the treatment of hyperuricemia and gout, the potential application of phytochemicals has been widely studied.
Bencsik T, Balázs O, Vida RG, Zsidó BZ, Hetényi C, Valentová K, Poór M.   +6 more
europepmc   +2 more sources

Inhibition of resistant triple-negative breast cancer cells with low-dose 6-mercaptopurine and 5-azacitidine. [PDF]

Oncotarget, 2021
Highly adaptable breast cancer cells that can opportunistically switch between proliferation and quiescence are often responsible for disease relapse. We have developed a function-based selection strategy for such resistant cells, exemplified by SUM149 ...
Singh B, Sarli VN, Lucci A.
europepmc   +2 more sources

Genetic Determinants of Hematopoietic Toxicity Risk in Thai Pediatric Patients Undergoing 6-Mercaptopurine Treatment. [PDF]

Clin Transl Sci
ABSTRACT The nucleoside diphosphate‐linked moiety X‐type motif 15 (NUDT15) has been identified as a key genetic determinant of 6‐mercaptopurine (6‐MP)‐induced hematopoietic toxicity in populations with a high frequency of NUDT15 variants but a low frequency of thiopurine S‐methyltransferase (TPMT) variants.
Khaeso K, Chainansamit SO, Kuwatjanakul P, Komvilaisak P, Nakkam N, Suwannaying K, Vannaprasaht S, Dornsena A, Tassaneeyakul W.   +8 more
europepmc   +2 more sources

Precision therapy of 6-mercaptopurine in Chinese children with acute lymphoblastic leukaemia. [PDF]

Br J Clin Pharmacol, 2020
Chinese children are more susceptible to the development of thiopurine‐induced leukopenia compared with Caucasian populations. The aim of our study was to establish a 6‐mercaptopurine (6‐MP) dose–concentration–response relationship through exploration of
Zhou Y, Wang L, Zhai XY, Wen L, Tang F, Yang F, Liu XT, Dong L, Zhi LJ, Shi HY, Hao GX, Zheng Y, Jacqz-Aigrain E, Wang TY, Zhao W.   +14 more
europepmc   +2 more sources

Preparation, Characterization, Pharmacokinetic, and Therapeutic Potential of Novel 6-Mercaptopurine-Loaded Oral Nanomedicines for Acute Lymphoblastic Leukemia

International Journal of Nanomedicine, 2021
Background Acute lymphoblastic leukemia (ALL) is the most common hematologic malignancy in children. It requires a long and rigorous course of chemotherapy treatments.
Yaru Zou, D. Mei, Jinjie Yuan, Jiaqi Han, Jiamin Xu, Ning Sun, Huan He, Changqing Yang, Li-bo Zhao   +8 more
semanticscholar   +1 more source

Inhibition of Xanthine Oxidase-Catalyzed Xanthine and 6-Mercaptopurine Oxidation by Flavonoid Aglycones and Some of Their Conjugates

International Journal of Molecular Sciences, 2020
Flavonoids are natural phenolic compounds, which are the active ingredients in several dietary supplements. It is well-known that some flavonoid aglycones are potent inhibitors of the xanthine oxidase (XO)-catalyzed uric acid formation in vitro. However,
Violetta Mohos, Eszter Fliszár-Nyúl, M. Poór   +2 more
semanticscholar   +1 more source

Allopurinol use during pediatric acute lymphoblastic leukemia maintenance therapy safely corrects skewed 6-mercaptopurine metabolism, improving inadequate myelosuppression and reducing gastrointestinal toxicity

Pediatric Blood & Cancer, 2020
Inadequate myelosuppression during maintenance therapy for acute lymphoblastic leukemia (ALL) is associated with an increased risk of relapse. One mechanism is skewed metabolism of 6‐mercaptopurine (6MP), a major component of maintenance therapy, which ...
Gordon Cohen, S. Cooper, E. Sison, Colleen Annesley, Mariam M. Bhuiyan, P. Brown   +5 more
semanticscholar   +1 more source

6-Mercaptopurine teratogenicity [PDF]

Postgraduate Medical Journal, 2002
We read with interest the review article on inflammatory bowel disease (IBD) in pregnancy.1 The author mentions that there has never been any demonstration of teratogenicity of 6-mercaptopurine (or azathioprine) in humans. We would like to report a case, which we encountered, of an infant with multiple congenital abnormalities whose mother received 6 ...
D H Tegay, R Tepper, J P Willner
openaire   +1 more source