Results 71 to 80 of about 8,386,191 (259)

Toxicity of azathioprine: why and when? analysis of the prevalence of polymorphism in Joinville, SC, Brazil

Arquivos de Gastroenterologia, 2012
CONTEXT: The use of thiopurine drugs such as azathioprine and 6-mercaptopurine has become quite common in the treatment of inflammatory bowel disease, transplantation and acute leukemias.
Gabriela Roncone Gastal, Simone Moreira, Caroline Furtado Noble, Leslie Ecker Ferreira, Paulo Henrique Condeixa de França, Mauro Pinho   +5 more
doaj   +1 more source

NUDT15 c.415C>T increases risk of 6-mercaptopurine induced myelosuppression during maintenance therapy in children with acute lymphoblastic leukemia

Haematologica, 2016
Acute lymphoblastic leukemia (ALL) is the most common hematologic malignancy in children[1][1]. Prolongation of therapy by incorporating a maintenance phase, containing 6-mercaptopurine (6-MP) as the backbone, has improved treatment outcomes in pediatric
Kanhatai Chiengthong, C. Ittiwut, Sasipa Muensri, J. Sophonphan, D. Sosothikul, P. Seksan, K. Suppipat, K. Suphapeetiporn, V. Shotelersuk   +8 more
semanticscholar   +1 more source

Adalimumab‐responsive Monogenic Inflammatory Bowel Disease With Pseudopolyposis Characteristic of TGFBR2 Variant in Loeys‐Dietz Syndrome

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Loeys‐Dietz syndrome (LDS) is an autosomal dominant connective tissue disorder caused by pathogenic variants in TGFBR1 or TGFBR2. It is characterized by vascular fragility, skeletal abnormalities, and predisposition to allergic and inflammatory conditions, including monogenic inflammatory bowel disease (IBD).
Tomomitsu Sado, Satoshi Ukai, Shingo Kurasawa, Yosuke Kono, Norio Hasuda, Mai Iwaya, Takaya Nakane, Tomomi Yamaguchi, Tomoki Kosho, Yoshiko Nakayama   +9 more
wiley   +1 more source

Successful private–public funding of paediatric medicines research: lessons from the EU programme to fund research into off-patent medicines [PDF]

, 2014
The European Paediatric Regulation mandated the European Commission to fund research on off-patent medicines with demonstrated therapeutic interest for children.
Baiardi, P, Bonifazi, D, Bonifazi, F, Ceci, A, Chiron, C, Davies, E H, Eichler, I, Felisi, M, Giannuzzi, V, Giaquinto, C, Jacqz-Aigrain, E, Neubert, A, on behalf of the GRiP Consortium,, Pressler, R, Rabe, H, Ruggieri, L, Turner, M A, Whitaker, M J   +17 more
core   +1 more source

Is Micronucleus Assay a Suitable Biomarker for Evaluating the Cancer Risk in Professionals Exposed to Antineoplastic Drugs? A Systematic Review

Journal of Applied Toxicology, Volume 46, Issue 3, Page 733-753, March 2026.
ABSTRACT The widespread use of antineoplastic drugs in cancer treatment has led to significant concerns regarding the potential health risks posed to healthcare professionals involved in the preparation, administration, and handling of these chemical compounds, including genotoxicity.
Thiago Guedes Pinto, Lorrany da Silva Avanci, Gabriel Carvalhal de Aguiar, Daniel Vitor de Souza, Patricia Ramos Cury, Ana Claudia Muniz Renno, Daniel Araki Ribeiro   +6 more
wiley   +1 more source

NADH‐Reductive Stress Induced by Dihydrolipoamide Dehydrogenase Activation Contributes to Cuproptosis

Advanced Science, Volume 13, Issue 9, 13 February 2026.
This study demonstrates a cuproptosis mechanism involving nicotinamide adenine dinucleotide (NADH)‐reductive stress in neural cells. Copper activates dihydrolipoamide dehydrogenase under mitochondrial pH, accumulating NADH. Copper also induces mitochondrial permeability transition pore opening, facilitating NADH translocation to the cytosol and ...
Si‐Yi Zhang, Xing‐Hua Ren, Cheng‐Hong Zhang, Zhan‐You Wang   +3 more
wiley   +1 more source

6-Mercaptopurine attenuates tumor necrosis factor-α production in microglia through Nur77-mediated transrepression and PI3K/Akt/mTOR signaling-mediated translational regulation

Journal of Neuroinflammation, 2016
The pathogenesis of several neurodegenerative diseases often involves the microglial activation and associated inflammatory processes. Activated microglia release pro-inflammatory factors that may be neurotoxic.
Hsin-Yi Huang, Hui‐Fen Chang, M. Tsai, Jhih-Si Chen, Mei‐Jen Wang   +4 more
semanticscholar   +1 more source

The Marriage of Metal Nanoclusters With Reticular Frameworks: Synthetic Strategies and Biomedical Applications

Aggregate, Volume 7, Issue 2, February 2026.
The integration of metal nanoclusters (MNCs) with reticular frameworks (RFs) has recently emerged as a powerful strategy to create composite materials with enhanced and synergistic functionalities. This review provides an overview of the synthetic strategies developed for constructing MNCs/RFs composites and their recent advances in biomedical ...
Wenfeng Liu, Qinyin Yin, Li‐Li Tan, Li Shang   +3 more
wiley   +1 more source

Charge Transfer-oxy Radical Mechanism for Anti-cancer Agents [PDF]

, 1986
The proposal is advanced that anti-cancer drugs generally function by charge transfer resulting in formation of toxic oxy radicals which destroy the neoplasm.
Ames, James R., Cox, O., Elo, Hannu, Kovacic, Peter, Lumme, Paavo, Ryan, Michael D.   +5 more
core   +1 more source

Induction of Mineralization [PDF]

, 2014
Vascular mineralization contributes to the high cardiovascular morbidity and mortality in patients who suffer from chronic kidney disease and in individuals who have undergone solid organ transplantation. The immunosuppressive regimen used to treat these
Giet, Markus van der, Höhne, Matthias, Prüfer, Jasmin, Prüfer, Nicole, Schuchardt, Mirjam, Tölle, Markus, Zidek, Walter   +6 more
core   +1 more source