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Enantioselectivity in Metabolism and Toxicity of 6PPD-Quinone in Salmonids

Environmental Science & Technology
The toxicity of N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6PPD-Q) in salmonids has been found to be sensitive to even minor structural changes on its alkyl side chain. Inspired by this, we herein isolated the enantiomers of 6PPD-Q and tested their in vitro metabolism and toxicity in rainbow trout (O.
Rui Li   +8 more
openaire   +2 more sources

Enantioselectivity in human urinary excretion of N-(1,3-dimethylbutyl)-N’-phenyl-1,4-benzenediamine (6PPD) and 6PPD-quinone

Environmental Pollution
Human exposure to of N-(1,3-dimethylbutyl)-N'-phenyl-1,4-benzenediamine (6PPD) has raised global concerns due to its documented toxic effects, including hepatotoxicity, metabolic disruption, and potential contributions to organ damage. 6PPD-quinone (6PPD-Q), a ubiquitous transformation product of 6PPD, has been identified as a major toxicant linked to ...
Hanfeng, Chen   +5 more
openaire   +2 more sources

Pakchoi (Brassica rapa L.) Modulates the Antioxidant System and Energy Metabolism in Response to 6PPD and 6PPD-Q

Journal of Agricultural and Food Chemistry
The widespread presence of the emerging contaminants N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and its derivative 6PPD-quinone (6PPD-Q), along with their associated environmental risks, has garnered significant public concern. To assess the food safety risk of 6PPD and its oxidized product 6PPD-Q in the environment, we explored the ...
Jinzheng Liu   +7 more
openaire   +2 more sources

Effects of biochar on the mobility and bioavailability of 6PPD, 6PPD-Q, and antimony in tire wear-impacted rhizosphere soil

Journal of Hazardous Materials
A pervasive environmental pollutant (tire wear particle (TWP)) leaches hazardous additives including N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD), 6PPD-quinone (6PPD-Q), and antimony (Sb) into thesoil-rhizosphere, which creates considerable ecological and agricultural hazards.
Stanley Chukwuemeka Ihenetu   +5 more
openaire   +2 more sources

Genome wide responses of the water flea, Daphnia carinata, to 6PPD and its oxidation product 6PPD-quinone

Journal of Hazardous Materials
The tyre additive N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and its oxidation product 6PPD-quinone (6PPD-Q) have emerged as potent toxicants in freshwater ecosystems, with 6PPD reacting with ozone to yield the more toxic 6PPD-Q. To characterise genome-wide responses to these contaminants, we used Daphnia carinata, an indicator species ...
Anupama Kumar   +6 more
openaire   +2 more sources

Oral exposure to tire rubber-derived contaminant 6PPD and 6PPD-quinone induce hepatotoxicity in mice

Science of the Total Environment, 2023
Xinquan Wang   +2 more
exaly  

[Comparison on neurotoxicity and immunotoxicity between 6PPD and 6PPD-Q in zebrafish under equimolar exposure conditions].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology
N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and its derivative N-(1,3-dimethylbutyl)-N'-phenyl-p-benzoquinone (6PPD-Q) have been widely detected in the environment and pose potential threats to ecosystems and human health. Given that 6PPD can be equimolarly converted to 6PPD-Q in the environment and organisms, the toxicity differences and
Linghao, Meng   +6 more
openaire   +1 more source

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