Results 101 to 110 of about 216 (131)

Photoaging enhances the leaching of di(2-ethylhexyl) phthalate and transformation products from polyvinyl chloride microplastics into aquatic environments. [PDF]

Commun Chem
Henkel C, Hüffer T, Peng R, Gao X, Ghoshal S, Hofmann T.   +5 more
europepmc   +1 more source

Indole-3-Carboxaldehyde Alleviates LPS-Induced Intestinal Inflammation by Inhibiting ROS Production and NLRP3 Inflammasome Activation. [PDF]

Antioxidants (Basel)
Cao J, Bao Q, Hao H.
europepmc   +1 more source

Maternal and infant gut microbiome. [PDF]

Imeta
Wang H, Tin F, Chen H, Jiao F, Wu M, Sun S, Lin L, Li D, Zheng H, Niu Z, Lan M, Yilmaz B, Eriksson JG, Wang M, Macpherson A, Clemente JC, Xu J, Xie RH, Zheng X, Zhou T, Wang J, Shen W, Huang B, Chen X, Li H, He Y.   +25 more
europepmc   +1 more source

Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications. [PDF]

Signal Transduct Target Ther
Akter S, Madhuvilakku R, Kar AK, Nila IS, Liu P, Inuzuka H, Wei W, Hong Y.   +7 more
europepmc   +1 more source

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6PPD and its metabolite 6PPDQ induce different developmental toxicities and phenotypes in embryonic zebrafish

Journal of Hazardous Materials, 2023
The automobile tire antioxidant N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and its quinone metabolite 6PPDQ have recently received much attention for their acute aquatic toxicity. The present study investigated the mechanistic developmental toxicity of 6PPD and 6PPDQ in embryonic zebrafish.
Jiangfei Chen, Chenglian Bai
exaly   +3 more sources

Transformation of 6PPDQ during disinfection: Kinetics, products, and eco-toxicity assessment

Water Research
N-phenyl-N'-(1,3-dimethyl butyl)-p-phenylenediamine-quinone (6PPDQ) currently arouses broad concerns because of its acute lethality to coho salmon and rainbow trout at environmentally relevant concentrations and the wide occurrence in runoff-impacted water.
Chang Jing, Tao Zhang, Jean-Philippe Croue   +2 more
exaly   +3 more sources

6PPDQ induces cardiomyocyte senescence via AhR/ROS-mediated autophagic flux blockage

Environmental Pollution
Recently, attention has been drawn to the adverse outcomes of N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6PPDQ) on human health, but its cardiac toxicity has been relatively understudied. This work aims to investigate the effects of 6PPDQ on differentiated H9c2 cardiomyocytes.
Yan Jiang
exaly   +3 more sources

Combined Analysis of Network Toxicology and Multiomics Revealed the Potential Mechanism of 6PPDQ-Induced Hepatotoxicity in Mice

Environmental Science & Technology
6PPDQ, a rubber tire-derived environmental pollutant, exhibits significant hepatotoxicity. However, its hepatotoxic mechanisms remain insufficiently studied and systematically evaluated. This study integrated network toxicology, transcriptomics, and metabolomics to investigate its toxicity mechanisms.
Zhang Ziwei
exaly   +3 more sources

Associations of human exposure to 6PPD and 6PPDQ with colorectal cancer: A mixture analysis

Environmental Pollution
N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and its oxidation product, 6PPD-quinone (6PPDQ), are widely present in the environment. Toxicological studies have demonstrated that they can induce adverse health effects on the intestinal system.
Hangbiao Jin
exaly   +3 more sources