Results 111 to 120 of about 216 (131)

Spatiotemporal variation of 6PPD and 6PPDQ in dust and soil from e-waste recycling areas

Science of the Total Environment
N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and its derivative 6PPDQ have been detected in various environmental media, with harmful consequences for both ecosystems and biological health. However, the distribution of 6PPD and 6PPDQ in areas around e-waste recycling areas is currently unknown. We collected soil and dust samples from areas
Xia Huo, Xijin Xu
exaly   +3 more sources

Stereoselective biotransformation and risk assessment of chiral 6PPDQ in the aquatic ecosystems with experimental-computational synergy

Water Research
The prevalent emerging contaminant 6PPD-quinone (6PPDQ) in aquatic environments has attracted great attention due to its acute mortality in coho salmon when exposed to urban runoff. It cannot be ignored that 6PPDQ exists as a pair of enantiomers (R-6PPDQ and S-6PPDQ), which may undergo enantioselective transformation in aquatic organisms and cause more
Kun Lu, Meizhen Wang, Dan Huang
exaly   +3 more sources

Elucidating organ-specific and cross-organ toxic effects of 6PPDQ in mice via integrated network toxicology and multi-omics analysis

N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6PPDQ) is an emerging pollutant generated via environmental oxidation of tire-derived 6PPD. Although concerns have been raised about its potential toxicity, the organ-specific and cross-organ toxicological mechanisms in mammalian liver and kidney remain poorly understood.
Jiewei Deng, Xinyan Li, Wang Chao, Shuting Zhong, Lili Jin, Yunyun Yang, Chunyan Hao, Tiangang Luan, Yuejia Wu, Yankeng Wang   +9 more
core   +3 more sources

AHR/cyp1b1 signaling-mediated extrinsic apoptosis contributes to 6PPDQ-induced cardiac dysfunction in zebrafish embryos

Environmental Pollution
N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone (6PPDQ) has raised significant concerns due to its widespread distribution and high toxicity to aquatic organisms. However, the cardiac developmental toxicity of 6PPDQ and the underlying mechanisms remain unclear.
Keqi Hu
exaly   +3 more sources

Network toxicology and multi-omics analyses identify diagnostic genes and elucidate underlying mechanisms of 6PPDQ-induced hepatocellular carcinoma

Environmental Pollution
With the rapid expansion of tire production, the antioxidant N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and its transformation product, 6PPD-quinone (6PPDQ), have emerged as widespread environmental contaminants with demonstrated toxicity.
Rongli Sun, Yuepu Pu, Yuxi Zhang
exaly   +3 more sources

6PPD and 6PPDQ exposure promote the proliferation and migration of non-small cell lung cancer cells through PTEN dysfunction and ARG2-mediated metabolic reprogramming

Journal of Hazardous Materials
N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) is a widely used antioxidant in tire rubber. Exposure to 6PPD and its quinone derivative, 6PPDQ, has increasingly been linked to environmental pollution and potential health risks. Given the established association between environmental contaminants and the incidence of lung cancer-particularly ...
Xinyan Li, Tiangang Luan, Jiewei Deng
exaly   +3 more sources

Investigating the Potential Effects of 6PPDQ on Clear Cell Renal Cell Carcinoma via Network Toxicology and Molecular Docking Analysis With In Vitro Experimental Validation

Journal of Applied Toxicology
ABSTRACT N ‐(1,3‐Dimethylbutyl)‐ N ′‐phenyl‐ p ‐phenylenediamine‐quinone (6PPDQ), as a recently identified environmental toxicant, has garnered significant attention because of its widespread detection in ecosystems
Shengde Wu, Yifan Hong
exaly   +3 more sources

Multi-omics insights into 6PPD- and 6PPDQ-induced gut-liver axis disruption and non-alcoholic fatty liver disease progression in zebrafish (Danio rerio)

Journal of Hazardous Materials
The pervasive environmental presence of N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and its transformation product, 6PPD-quinone (6PPDQ), has raised concerns about their potential toxicity, yet their interactions with the gut microbiota at environmentally relevant concentrations remain poorly understood.
Zhenlie Huang, Hongyi Xian, Yuji Huang   +2 more
exaly   +3 more sources

Exploration of emerging environmental pollutants 6PPD and 6PPDQ in honey and fish samples

Food Chemistry, 2022
N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone (6PPDQ) can pose a threat to human health through the food chain because of their ubiquitous presence in the environment and the biotoxicity on organisms.
Jiawen, Ji, Changsheng, Li, Bingjie, Zhang, Wenjuan, Wu, Jianli, Wang, Jianhui, Zhu, Desheng, Liu, Rumin, Gao, Yongqiang, Ma, Sen, Pang, Xuefeng, Li   +10 more
openaire   +2 more sources

Repeated versus single exposure to 6PPDQ induces differential toxicity in Escherichia coli revealed by oxidative stress, energy metabolism, extracellular polymeric substances structure, and metabolic response

Journal of Water Process Engineering
Shengnan Shi, Qianzhi Zeng, Yunhong Pu   +2 more
exaly   +2 more sources