Results 121 to 130 of about 216 (131)

Life stage, chorion, and hatchery origin differences in the toxicity of 6PPDQ to coho salmon

Canadian Journal of Fisheries and Aquatic Sciences
Several salmonid species die from acute exposure to 2-((4-methylpentan-2-yl)amino)-5-(phenylamino)cyclohexa-2,5-diene-1,4-dione (6PPDQ)—a ubiquitous pollutant that enters waterways via roadway runoff. Coho salmon ( Oncorhynchus kisutch) is the most sensitive species.
Garrett M. Foster, Melissa K. Driessnack, Melissa Gonzalez, Edward P. Kolodziej, Jenifer K. McIntyre   +4 more
openaire   +1 more source

Neurological impairment is crucial for tire rubber-derived contaminant 6PPDQ-induced acute toxicity to rainbow trout

Science Bulletin
N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6PPDQ) has attracted significant attention due to its highly acute lethality to sensitive salmonids. However, studies investigating the mechanisms underlying its acute toxicity have been lacking.
Xiao-Liang, Liao, Zhi-Feng, Chen, Shi-Ping, Ou, Qian-Yi, Liu, Shan-Hong, Lin, Jia-Ming, Zhou, Yujie, Wang, Zongwei, Cai   +7 more
openaire   +2 more sources

Contribution of AhR-mediated activation of the AC/cAMP/PKA cascade to 6PPDQ-induced cardiac defects in zebrafish

Environmental Research
The ecological and health risks of 6PPDQ (N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone) have raised significant concerns. We recently demonstrated that the Aryl Hydrocarbon Receptor (AhR) mediates 6PPDQ-caused extrinsic apoptosis and heart defects; however, the underlying molecular pathways remain elucidated.
Mengya Zhai, Jinhao Li, Mingxuan Zhang, Xinyue Yang, Qianqian Gan, Yan Jiang, Tao Chen   +6 more
openaire   +2 more sources

Acute Toxicity of 6PPDQ, 6PPD, and Other Transformation Products to a Freshwater Mussel (Lampsilis siliquoidea, Barnes 1823)

Bulletin of Environmental Contamination and Toxicology
The tire rubber antioxidant N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and its transformation product, 6PPD-quinone (6PPDQ), have garnered much research attention since the latter was identified as the causative agent of urban runoff mortality syndrome in Coho Salmon (Oncorhynchus kisutch) in the Pacific Northwest of the United States ...
David J. Soucek, Rebecca A. Dorman, Jeffery A. Steevens, Viviane Yargeau, Marco Pineda, Christopher D. Metcalfe, Erin R. Bennett   +6 more
openaire   +2 more sources

Exploring the toxicological impact of 6PPDQ exposure on psoriasis through network toxicology, machine learning, and multidimensional bioinformatics analysis

Environmental Pollution
N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6PPDQ), a derivative of the tire antioxidant 6-PPD, has recently emerged as an environmental contaminant of concern. This study employed a network toxicology framework to explore its potential role in psoriasis.
Xulei Zuo, Yuxi Zhang, Xiaoyu Hou, Cong Zhang, Juan Zhang   +4 more
openaire   +2 more sources

The AhR/ROS-mediated lipid peroxidation pathway contributes to 6PPDQ-induced intestine-specific injury in zebrafish during embryonic development

Fish & Shellfish Immunology
N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6PPDQ), an emerging environmental contaminant derived from tire rubber, has been reported to accumulate at higher levels in the intestine than in other tissues of zebrafish, raising concerns regarding intestinal susceptibility. However, its potential developmental toxicity toward the intestine
Zhe Wang, Yao Hu, Mingjun Zhu, Xinyue Yang, Qiancheng Huang, Anying Zhang, Xinyan Wang, Hong Zhou   +7 more
openaire   +2 more sources

Acute Toxicity of 4-hydroxydiphenylamine (4-HDPA) and N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone (6PPDQ), transformation products of 6PPD, to early instars of the mayfly, Neocloeon triangulifer

Environmental Toxicology and Chemistry
Abstract Our analysis of water samples collected during a rain event from two urban rivers in the Greater Toronto area, Ontario, Canada, indicated that selected transformation products (TPs) of the tire antioxidant, N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD), including 6PPD-quinone (6PPDQ) and 4-hydroxydiphenylamine (4 ...
David J, Soucek, Rebecca A, Dorman, Jeffery A, Steevens, Viviane, Yargeau, Marco, Pineda, Erin R, Bennett, Christopher D, Metcalfe   +6 more
openaire   +2 more sources

Binding of N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine Quinone (6PPDQ) to Mitochondrial Proteins Provokes Mitochondria Dysfunction.

Chemical research in toxicology
N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine Quinone (6PPDQ) not only causes acute mortality in salmon but also induces toxicities in other living organisms. The electrophilic quinone moiety in the 6PPDQ molecular structure can participate in binding to the cysteine residues that ubiquitously exist in protein nucleophiles, which are responsible ...
Naijie, Wei, Xiaowen, Yan, Mingyue, Yu, Rong, Li, Zhixin, Xiao, Shi, Chen, Limin, Yang, Qiuquan, Wang, Qian, Liu, Guibin, Jiang   +9 more
openaire   +1 more source

Chemoproteomic Profiling Reveals 6PPDQ-Mediated Neurotoxicity in Rainbow Trout through Disruption of the Glutamate–Glutamine Cycle

Environmental Science & Technology
Ruiqin Cheng, Wei Zhang, Yalan Su, Zhiyi Yang, Xiaojian Shao   +4 more
openaire   +1 more source

Binding of N -(1,3-Dimethylbutyl)- N’ -phenyl- p -phenylenediamine Quinone (6PPDQ) to Mitochondrial Proteins Provokes Mitochondria Dysfunction

Chemical Research in Toxicology
Naijie Wei, Xiaowen Yan, Mingyue Yu, Rong Li, Zhixin Xiao, Shi Chen, Limin Yang, Qiuquan Wang, Qian Liu, Guibin Jiang   +9 more
openaire   +1 more source