Results 31 to 40 of about 13,198 (194)

Diatoms synthesize sterols by inclusion of animal and fungal genes in the plant pathway [PDF]

, 2020
Diatoms are ubiquitous microalgae that have developed remarkable metabolic plasticity and gene diversification. Here we report the first elucidation of the complete biosynthesis of sterols in the lineage.
, Angela, d’Ippolito, Giuliana, Fontana, Angelo, GALLO, CARMELA, LANDI, SIMONE, MANZO, EMILIANO, Nuzzo, Genoveffa, Sardo &   +7 more
core   +1 more source

Non-skeletal activities of vitamin d: From physiology to brain pathology [PDF]

, 2019
Vitamin D is a secosteroid hormone regulating the expression of almost 900 genes, and it is involved in the regulation of calcium and phosphate metabolism, immune response, and brain development.
Bruna Lo Sasso, Chiara Bellia, Concetta Scazzone, Giorgia Iacolino, Giulia Bivona, Luisa Agnello, Marcello Ciaccio   +6 more
core   +1 more source

7-Dehydrocholesterol is an endogenous suppressor of ferroptosis [PDF]

, 2021
Abstract Ferroptosis is a form of cell death that has received considerable attention not only as a means to eradicate defined tumour entities but also because it provides unforeseen insights into the metabolic adaptation exploited by tumours to counteract phospholipid oxidation.
Jose Pedro Friedmann Angeli, Florencio Porto Freitas, Palina Nepachalovich, Lohans Puentes, Omkar Zilka, Alex Inague, Svenja Lorenz, Viktoria Kunz, Helene Nehring, Thamara Nishida Xavier da Silva, Zhiyi Chen, Sebastian Doll, Werner Schmitz, Peter Imming, Sayuri Miyamoto, Judith Klein-Seetharaman, Lokender Kumar, Thiago Cardoso Genaro-Mattos, Karoly Mirnics, Svenja Meierjohann, Matthias Kroiss, Isabel Weigand, Kurt Bommert, Ralf Bargou, Ana Garcia-Saez, Derek Pratt, Maria Fedorova, Ann Wehmann, Aline Horling, Georg Bornkamm, Marcus Conrad   +30 more
openaire   +1 more source

Oxidized derivatives of 7-dehydrocholesterol induce growth retardation in cultured rat embryos: a model for antenatal growth retardation in the Smith-Lemli-Opitz syndrome

Journal of Lipid Research, 1999
7-Dehydrocholesterol accumulates in fetuses affected by the Smith-Lemli-Opitz syndrome as a result of a deficit in the ultimate step of cholesterol synthesis catalyzed by Δ7 reductase.
Wassila Gaoua, Françoise Chevy, Charles Roux, Claude Wolf   +3 more
doaj   +1 more source

Identification of 8-dehydrocholesterol (cholesta-5,8-dien-3 beta-ol) in patients with Smith-Lemli-Opitz syndrome.

Journal of Lipid Research, 1995
Cholesta-5,8-dien-3 beta-ol (8-dehydrocholesterol) and cholesta-5,7-dien-3 beta-ol (7-dehydrocholesterol) were isolated from the fecal neutral sterol fraction from homozygotes with Smith-Lemli-Opitz syndrome.
A K Batta, G S Tint, S Shefer, D Abuelo, G Salen   +4 more
doaj   +1 more source

Defective conversion of 7-dehydrocholesterol to cholesterol in cultured skin fibroblasts from Smith-Lemli-Opitz syndrome homozygotes

Journal of Lipid Research, 1995
The Smith-Lemli-Opitz syndrome is a common birth defect syndrome characterized biochemically by low plasma cholesterol levels and high concentrations of the cholesterol precursor 7-dehydrocholesterol.
A Honda, G S Tint, G Salen, A K Batta, T S Chen, S Shefer   +5 more
doaj   +1 more source

Effect of a new inhibitor of cholesterol biosynthesis (AY 9944) on serum and tissue sterols in the rat

Journal of Lipid Research, 1966
AY 9944 is a novel inhibitor of cholesterol biosynthesis which appears to act on the Δ7-reductase enzyme, interfering with the conversion of 7-dehydrocholesterol to cholesterol.
L. Horlick
doaj   +1 more source

Vitamin D in plants: a review of occurrence, analysis, and biosynthesis. [PDF]

, 2013
The major function of vitamin D in vertebrates is maintenance of calcium homeostasis, but vitamin D insufficiency has also been linked to an increased risk of hypertension, autoimmune diseases, diabetes and cancer. Therefore, there is a growing awareness
Jakobsen, Jette, Jäpelt, Rie Bak
core   +2 more sources

Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol

Journal of Lipid Research, 2001
Infants with the cholesterol synthesis defect Smith-Lemli-Opitz syndrome (SLO) have reduced activity of the enzyme 7-dehydrocholesterol-7-reductase and accumulate 7-dehydrocholesterol, with the highest concentration in the brain.
Ingemar Björkhem, Lena Starck, Ulla Andersson, Dieter Lütjohann, Sara von Bahr, Irina Pikuleva, Amir Babiker, Ulf Diczfalusy   +7 more
doaj   +1 more source

Individual and simultaneous treatment with antipsychotic aripiprazole and antidepressant trazodone inhibit sterol biosynthesis in the adult brain

Journal of Lipid Research, 2022
Polypharmacy, or the simultaneous use of multiple drugs to treat a single patient, is a common practice in psychiatry. Unfortunately, data on the health effects of commonly used combinations of medications are very limited.
Marta Balog, Allison Anderson, Thiago C. Genaro-Mattos, Zeljka Korade, Karoly Mirnics   +4 more
doaj   +1 more source