Results 41 to 50 of about 13,198 (194)
Engineering of Saccharomyces cerevisiae for 24-Methylene-Cholesterol Production
Biomolecules, 2021 24-Methylene-cholesterol is a necessary substrate for the biosynthesis of physalin and withanolide, which show promising anticancer activities. It is difficult and costly to prepare 24-methylene-cholesterol via total chemical synthesis. In this study, we
Jiao Yang, Changfu Li, Yansheng Zhang
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Journal of Lipid Research, 1968 The effect of long-term administration of AY-9944, a specific inhibitor of cholesterol biosynthesis, was examined in rats maintained on diets with low and high cholesterol and fat content.
D. Dvornik, P. Hill
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Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer. [PDF]
, 2016 1,25 dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D, and calcium regulate epidermal differentiation. 1,25(OH)2D exerts its effects through the vitamin D receptor (VDR), a transcription factor in the nuclear hormone receptor family ...
Bikle, Daniel D +4 more
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Journal of Lipid Research, 2005 Cholesterol is a major lipid component of the plasma membrane in animal cells. In addition to its structural requirement, cholesterol is essential in cell proliferation and other cell processes.
Carlos Fernández +3 more
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Vitamin D: Newer Concepts of Its Metabolism and Function at the Basic and Clinical Level. [PDF]
, 2020 The interest in vitamin D continues unabated with thousands of publications contributing to a vast and growing literature each year. It is widely recognized that the vitamin D receptor (VDR) and the enzymes that metabolize vitamin D are found in many ...
Bikle, Daniel D
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Atrioventricular canal defect and genetic syndromes: the unifying role of sonic hedgehog [PDF]
, 2019 The atrioventricular canal defect (AVCD) is a congenital heart defect (CHD) frequently associated with extracardiac anomalies (75%). Previous observations from a personal series of patients with AVCD and "polydactyly syndromes" showed that the distinct ...
Baban, A +9 more
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7-Dehydrocholesterol reductase activity is independent of cytochrome P450 reductase [PDF]
The Journal of Steroid Biochemistry and Molecular Biology, 2011 7-Dehydrocholesterol reductase (DHCR7) catalyzes the final step in cholesterol synthesis. The enzyme utilizes NADPH as a source of electrons and has been reported to require NADPH-cytochrome P450 reductase (POR) as its redox partner. To test this hypothesis, microsomes were prepared from the livers of mice in which hepatic cytochrome P450 reductase ...
Ling, Zou, Li, Li, Todd D, Porter
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Journal of Lipid Research, 2000 The Smith-Lemli-Opitz syndrome (SLOS) is a multiple malformation/mental retardation syndrome caused by a deficiency of the enzyme 7-dehydrocholesterol Δ7-reductase.
Robert D. Steiner +4 more
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Sterols in blood of normal and Smith-Lemli-Opitz subjects
Journal of Lipid Research, 2001 Smith-Lemli-Opitz syndrome (SLOS) is a hereditary disorder in which a defective gene encoding 7-dehydrocholesterol reductase causes the accumulation of noncholesterol sterols, such as 7- and 8-dehydrocholesterol.
Benfang Ruan +10 more
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Sterol profiles in plasma and erythrocyte membranes in patients with Smith-Lemli-Opitz syndrome: a six-year experience [PDF]
, 2011 Background: This study reports our experience over the last six years in the diagnosis of Smith-Lemli-Opitz syndrome and other inborn errors of cholesterol biosynthesis.
A. Nappi +6 more
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