Results 101 to 110 of about 416 (114)

Involvement of μ-opioid receptors in antinociception and inhibition of gastrointestinal transit induced by 7-hydroxymitragynine, isolated from Thai herbal medicine Mitragyna speciosa

European Journal of Pharmacology, 2006
7-hydroxymitragynine, a constituent of the Thai herbal medicine Mitragyna speciosa, has been found to have a potent opioid antinociceptive effect. In the present study, we investigated the mechanism of antinociception and the inhibitory effect on gastrointestinal transit of 7-hydroxymitragynine, and compared its effects with those of morphine.
Kenjiro, Matsumoto, Yoshio, Hatori, Toshihiko, Murayama, Kimihito, Tashima, Sumphan, Wongseripipatana, Kaori, Misawa, Mariko, Kitajima, Hiromitsu, Takayama, Syunji, Horie   +8 more
openaire   +2 more sources

Interactions of Kratom Alkaloids–Mitragynine, 7-Hydroxymitragynine, and Mitragynine Pseudoindoxyl with Lipid Bilayers: A Molecular Dynamics Study

International Journal of Pharmaceuticals, Nutraceuticals and Cosmetic Science
Kratom, a plant native to Southeast Asia, has gained attention as a potential alternative to opioids for pain relief and managing withdrawal symptoms. However, concerns about its safety persist due to reported adverse effects and drug interactions. Despite having at least 50 alkaloids, the pharmacological properties of kratom remain poorly understood ...
Nur Syahirunelisa Mohd Zubri, Nur Alya Amirah Azhar, Nur Aqasyah Amran, Shirley In Siu Weng, Asmah Awal, Siti Azma Jusoh   +5 more
openaire   +1 more source

Rate and extent of mitragynine and 7‐hydroxymitragynine blood–brain barrier transport and their intra‐brain distribution: the missing link in pharmacodynamic studies

Addiction Biology, 2018
AbstractMitragyna speciosa is reported to be beneficial for the management of chronic pain and opioid withdrawal in the evolving opioid epidemic. Data on the blood–brain barrier (BBB) transport of mitragynine and 7‐hydroxymitragynine, the active compounds of the plant, are still lacking and inconclusive. Here, we present for the first time the rate and
Siti R. Yusof, Mahathir Mohd Uzid, Eng‐Huat Teh, Nur Aziah Hanapi, Mazlin Mohideen, Ahmad Saifuddin Mohamad Arshad, Mohd Nizam Mordi, Irena Loryan, Margareta Hammarlund‐Udenaes   +8 more
openaire   +2 more sources

In Vitro and In Vivo Pharmacokinetic Characterization of 7-Hydroxymitragynine, an Active Metabolite of Mitragynine, in Sprague-Dawley Rats

European Journal of Drug Metabolism and Pharmacokinetics
Kratom, a Southeast Asian tree, has been researched for its potential as a therapeutic for substance use disorders. The most abundant alkaloid in kratom, mitragynine, is being investigated individually for opioid use disorder. However, the active metabolite of mitragynine,7-hydroxymitragynine (7-HMG) has raised concerns because of its high binding ...
Yi-Hua Chiang, Siva Rama Raju Kanumuri, Michelle A. Kuntz, Alexandria S. Senetra, Erin C. Berthold, Shyam H. Kamble, Sushobhan Mukhopadhyay, Aidan J. Hampson, Christopher R. McCurdy, Abhisheak Sharma   +9 more
openaire   +2 more sources

Determination of Mitragynine and 7‐Hydroxymitragynine in Raw Kratom Plant Material by a Multisegment Injection Capillary Zone Electrophoresis‐Tandem Mass Spectrometry

Journal of Separation Science
ABSTRACTA novel validated analytical approach implementing multisegment injection strategy into the capillary zone electrophoresis‐tandem mass spectrometry hyphenation for determination of two psychoactive alkaloids, mitragynine (MIT), and 7‐hydoxymitraginine (7‐OH‐MIT), in kratom raw samples was introduced.
Andrea Horniakova, Peter Mikus, Juraj Piestansky   +2 more
openaire   +2 more sources

LC–MS-MS method for mitragynine and 7-hydroxymitragynine in hair and its application in authentic hair samples of suspected kratom abusers

Journal of Analytical Toxicology
Abstract Kratom is a natural psychoactive product known primarily in Southeast Asia, including Thailand, Malaysia, etc. It is also known as krathom, kakuam, ithang, thom (Thailand), biak-biak, ketum (Malaysia) and mambog (Philippines) and is sometimes used as an opium substitute. It is stimulant at doses of 1–5 g, analgesic at doses of 5–
Jongsook Rhee, Ilchung Shin, Jihyun Kim, Juseun Lee, Byungsuk Cho, Junghyun Kim, Meejung Park, Eunmi Kim   +7 more
openaire   +2 more sources

Determination of ADME properties of mitragynine, 7-hydroxymitragynine, and mitraphylline

Planta Medica, 2014
VK Manda, B Avula, Z Ali, IA Khan, LA Walker, SI Khan   +5 more
openaire   +1 more source

Complicating Factors Surrounding Concurrent Use of Kratom and a Novel 7-hydroxymitragynine Product Among a Participant Enrolled in a Kratom Clinical Trial

Journal of Addiction Medicine
Background: 7-Hydroxymitragynine (7-OH) is a highly selective mu opioid receptor agonist with binding affinity greater than morphine. Although trace amounts of 7-OH are found in kratom, it is formed by metabolism in humans after kratom ingestion.
Kirsten E. Smith, Siva Rama Raju Kanumuri, Abhisheak Sharma, Rachel Rattenni, Robert LeComte, Christopher R. McCurdy, Edward W. Boyer, Eric C. Strain   +7 more
openaire   +1 more source

Preliminary examination of mitragynine and 
7-hydroxymitragynine synthesis in response to production environment and postharvest techniques of Mitragyna speciosa

Acta Horticulturae, 2020
B.J. Pearson, S.M. Campbell, B. Avery, C. McCurdy, J. Francisco, A. Sharma, R. Kjelgren   +6 more
openaire   +1 more source

Assessment of abuse liability and respiratory effects of mitragynine and 7-hydroxymitragynine in rats

Journal of Pharmacological and Toxicological Methods
Julio D. Zuarth Gonzalez, Ragsdale K. Alexandria, Sushobhan Mukhopadyay, Christopher R. McCurdy, Lance R. McMahon, Jenny L. Wilkerson   +5 more
openaire   +1 more source