Results 91 to 100 of about 4,015 (203)
Metabolism of Various 8-Aminoquinolines in Rhesus Monkey.
Experimental Biology and Medicine, 1950 SummaryStudies on the metabolism of the 8-aminoquinolines, pamaquine, isopentaquine, primaquine, pentaquine, SN 13,058, and CN 1100, have been carried out in the rhesus monkey. As shown by differential analyses of the 8-aminoquinoline contents of plasma, each of the above compounds is degraded to alkali-soluble, ethylene dichloride-insoluble ...
H B, BUGHES, L H, SCHMIDT
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ChemMedChem, Volume 21, Issue 3, 12 February 2026.An enrichment map, developed using principal components analysis (PCA), shows the relative abundance of inhibitors of synthetic hemozoin (β‐hematin) formation in antiplasmodium chemical space. This 2‐dimensional landscape can be mined to unearth new chemotypes for antimalarial drug development.
Jessica L. Thibaud +9 more
wiley +1 more source
Recent advances using [Cp*Co(CO)I2] catalysts as a powerful tool for C-H functionalisation [PDF]
, 2017 Expansion of the synthetic chemists' toolbox is currently a topic of great interest, with successes providing access to novel compounds and more efficient routes towards new and known pharmaceuticals and agrochemicals.
Chirila, Paula G, Whiteoak, Christopher
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Some transition metal complexes of 8-aminoquinoline [PDF]
Journal of Inorganic and Nuclear Chemistry, 1965 Abstract The reaction of 8-aminoquinoline with chromium (III), manganese (II), iron (II) and (III), cobalt(II), nickel(II), copper(II), zinc(II), cadmium(II) and platinum(II) salts has been studied. In many instances definite compounds were prepared.
J.C. Fanning, L.T. Taylor
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Angewandte Chemie, Volume 138, Issue 7, 9 February 2026.Ni: neue Lösung für asymmetrische C(sp3)‐H‐Aktivierung. Die stereoselektive Synthese vollständig kohlenstoffsubstituierter quartärer Stereozentren gelingt durch eine enantioselektive C(sp3)‐H‐Arylierung unter Verwendung eines Ni‐Katalysators auf der Basis eines BINOL‐Derivaten.
Erwan Brunard +4 more
wiley +1 more source
Intermolecular Enantioselective Nickel‐Catalyzed Arylation of Un‐Activated C(sp3)─H Bond
Angewandte Chemie International Edition, Volume 65, Issue 7, 9 February 2026.Ni: a new solution for asymmetric C(sp3)─H activation. The stereoselective synthesis of all‐carbon quaternary stereogenic centres is achieved via enantioselective C(sp3)─H arylation using a Ni‐BINOL‐derived catalyst. Rational catalytic cycle design uncovers a new reaction pathway that can efficiently induce chiral information during the stereoselective
Erwan Brunard +4 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.Katalysatoren, die aus dem halogenverbrückten Methylnaphthyl‐Palladium‐Dimer [Pd(1‐MeNAP)Br]2 und Biarylphosphin‐Liganden in Kombination mit der Base LiHMDS generiert werden, katalysieren Buchwald‐Hartwig‐artige Aminierungen und para‐C–H‐Arylierungen von nicht‐aktivierten Arylfluoriden bereits bei 60 °C.
Jie Shen +4 more
wiley +1 more source
Pharmacological considerations in the design of anti-malarial drug combination therapies - is matching half-lives enough? [PDF]
, 2014 Anti-malarial drugs are now mainly deployed as combination therapy (CT), primarily as a mechanism to prevent or slow the spread of resistance. This strategy is justified by mathematical arguments that generally assume that drug 'resistance' is a binary ...
Hodel, Eva Maria
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High prevalence of antibodies to human herpesvirus 8 in relatives of patients with classic Kaposi's sarcoma from Sardinia [PDF]
, 1998 A survey for antibodies to a recombinant small viral capsid antigen (sVCA) of human herpesvirus type 8 (HHV‐8) was conducted in Sardinia, one of the world's highest incidence areas for classic Kaposi's sarcoma (KS). Prevalence of antibodies to HHV‐8 sVCA
Angeloni, Antonio +11 more
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Fluorimetric detection of tautomeric equilibria in 8-aminoquinolines
Talanta, 1985 The 1-methylquinolinium cations derived from 8-aminoquinoline and 8-amino-6-methoxyquinoline were prepared by methylation of the corresponding nitroquinolines and reduction of the nitro-compounds. The dissociation constants of the protonated species of these compounds are almost identical to those of doubly-protonated 8-aminoquinoline and 8-amino-6 ...
College of Pharmacy, University of Florida, Gainesville, Florida 32610, U.S.A. ( host institution ) +3 more
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