Results 11 to 20 of about 4,015 (203)

Identifying Drugs Associated With Parkinson's Disease Risk Using Machine Learning. [PDF]

Basic Clin Pharmacol Toxicol
ABSTRACT Machine learning (ML)–based methods have been proposed as a potential approach for identifying candidate drugs to be repurposed as disease‐modifying treatments for Parkinson's disease (PD). We applied an ML‐based signal detection method to identify drugs associated with PD and evaluated the method's generalizability.
Pylkkö E, Courtois É, Paakinaho A, Hartikainen S, Kaasinen V, Elbaz A, Thiébaut ACM, Ahmed I, Tolppanen AM.   +8 more
europepmc   +2 more sources

Catalyst controlled remote CH activation of 8-aminoquinolines with NFSI for CN versus CF coupling

Catalysis Communications, 2021
A catalyst-controlled selective functionalization of 8-aminoquinolines with N-fluorobenzenesulfonimide (NFSI) has been developed. The use of GTP-Cu catalysts leads to CN coupling products and whereas the CF coupling reaction is dominant for GPT-Ni ...
Kai Zheng, Enmu Zhou, Letian Zhang, Lixi Zhang, Wenbo Yu, Hao Xu, Chao Shen   +6 more
doaj   +1 more source

Primaquine for Plasmodium vivax radical cure: What we do not know and why it matters

International Journal for Parasitology: Drugs and Drug Resistance, 2021
Plasmodium vivax radical cure requires the administration of a blood schizonticide for killing blood-stage parasites and the addition of a drug able to kill hypnozoites, the dormant parasite stages residing in the liver of infected patients.
Jean Popovici, Kieran Tebben, Benoit Witkowski, David Serre   +3 more
doaj   +1 more source

A Review of the Current Status of G6PD Deficiency Testing to Guide Radical Cure Treatment for Vivax Malaria

Pathogens, 2023
Plasmodium vivax malaria continues to cause a significant burden of disease in the Asia-Pacific, the Horn of Africa, and the Americas. In addition to schizontocidal treatment, the 8-aminoquinoline drugs are crucial for the complete removal of the ...
Arkasha Sadhewa, Sarah Cassidy-Seyoum, Sanjaya Acharya, Angela Devine, Ric N. Price, Muthoni Mwaura, Kamala Thriemer, Benedikt Ley   +7 more
doaj   +1 more source

Submicroscopic carriage of Plasmodium falciparum and Plasmodium vivax in a low endemic area in Ethiopia where no parasitaemia was detected by microscopy or rapid diagnostic test. [PDF]

, 2015
BACKGROUND: Motivated by the success in malaria control that was documented over the last decade Ethiopia is aiming at malaria elimination by 2020 in selected districts.
Baidjoe, Amrish, Bousema, Teun, Drakeley, Chris, Grignard, Lynn, Hall, Tom, Lanke, Kjerstin, Mamo, Hassen, Pett, Helmi, Sutherland, Colin, Tadesse, Fitsum G   +9 more
core   +12 more sources

G6PD deficiency in malaria endemic areas of Nepal

Malaria Journal, 2020
Background Glucose-6-phosphate dehydrogenase (G6PD) deficiency is currently a threat to malaria elimination due to risk of primaquine-induced haemolysis in G6PD deficient individuals.
Baburam Marasini, Bibek Kumar Lal, Suman Thapa, Kiran Raj Awasthi, Bijay Bajracharya, Pratik Khanal, Sanjeev Neupane, Shambhu Nath Jha, Sanjaya Acharya, Smriti Iama, Madan Koirala, Dinesh Koirala, Suresh Bhandari, Ram Kumar Mahato, Arun Chaudhary, Pramin Ghimire, Rahachan Gharti Magar, Rajan Kumar Bhattarai, Gornpan Gornsawun, Pimsupah Penpitchaporn, Germana Bancone, Bhim Prasad Acharya   +21 more
doaj   +1 more source

Molecular characterization and mapping of glucose-6-phosphate dehydrogenase (G6PD) mutations in the Greater Mekong Subregion

Malaria Journal, 2019
Background Plasmodium vivax malaria elimination can only be achieved by the deployment of 8-aminoquinolines (primaquine and tafenoquine) in combination with ACT to kill both blood and liver-stage parasites.
Germana Bancone, Didier Menard, Nimol Khim, Saorin Kim, Lydie Canier, Chea Nguong, Koukeo Phommasone, Mayfong Mayxay, Sabine Dittrich, Malavanh Vongsouvath, Nadine Fievet, Jean-Yves Le Hesran, Valerie Briand, Sommay Keomany, Paul N. Newton, Gornpan Gorsawun, Kaelan Tardy, Cindy S. Chu, Orpreeya Rattanapalroj, Le Thanh Dong, Huynh Hong Quang, Nguyen Tam-Uyen, Nguyen Thuy-Nhien, Tran Tinh Hien, Michael Kalnoky, Francois Nosten   +25 more
doaj   +1 more source

KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. [PDF]

, 2014
Preventing relapses of Plasmodium vivax malaria through a radical cure depends on use of the 8-aminoquinoline primaquine, which is associated with safety and compliance issues.
Borboa, Rachel, Campo, Brice, Chatterjee, Arnab K, Chen, Zhong, Diagana, Thierry T, Gagaring, Kerstin, Glynne, Richard J, Klooster, Els J, Kocken, Clemens HM, Kuhen, Kelli, Leroy, Didier, Luty, Adrian, McNamara, Case W, Nagle, Advait, Plouffe, David M, Remarque, Edmond J, Roland, Jason, Sauerwein, Robert, Thomas, Alan W, van Amsterdam, Sandra M, van den Berg, Alexander, van Gemert, Geert-Jan, Voorberg-van der Wel, Annemarie, Winzeler, Elizabeth A, Yeung, Bryan KS, Zeeman, Anne-Marie   +25 more
core   +1 more source

Primaquine-induced haemolysis in females heterozygous for G6PD deficiency

Malaria Journal, 2018
Oxidative agents can cause acute haemolytic anaemia in persons with G6PD deficiency. Understanding the relationship between G6PD genotype and the phenotypic expression of the enzyme deficiency is necessary so that severe haemolysis can be avoided.
Cindy S. Chu, Germana Bancone, François Nosten, Nicholas J. White, Lucio Luzzatto   +4 more
doaj   +1 more source

4-Aminoquinoline-Based Adamantanes as Potential Anticholinesterase Agents in Symptomatic Treatment of Alzheimer’s Disease

Pharmaceutics, 2022
Considering that acetylcholinesterase (AChE) inhibition is the most important mode of action expected of a potential drug used for the treatment of symptoms of Alzheimer’s disease (AD), our previous pilot study of 4-aminoquinolines as potential human ...
Katarina Komatović, Ana Matošević, Nataša Terzić-Jovanović, Suzana Žunec, Sandra Šegan, Mario Zlatović, Nikola Maraković, Anita Bosak, Dejan M. Opsenica   +8 more
doaj   +1 more source