Nopol-Based Quinoline Derivatives as Antiplasmodial Agents
Molecules, 2021 Malaria remains a significant cause of morbidity and mortality in Sub-Saharan Africa and South Asia. While clinical antimalarials are efficacious when administered according to local guidelines, resistance to every class of antimalarials is a persistent ...
Rogers J. Nyamwihura +4 more
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Review of mass drug administration for malaria and its operational challenges. [PDF]
, 2015 Mass drug administration (MDA) was a component of many malaria programs during the eradication era, but later was seldomly deployed due to concerns regarding efficacy and feasibility and fear of accelerating drug resistance.
Chen, Ingrid +12 more
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Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones [PDF]
, 2008 A series of primaquine-derived imidazolidin-4-ones were screened for their in vitro activity against Pneumocystis carinii and Plasmodium falciparum W2 strain. Most compounds were active against P.
Jiri Gut +7 more
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Synthesis, In Silico Studies, Antiprotozoal and Cytotoxic Activities of Quinoline‐Biphenyl Hybrids [PDF]
, 2020 This is the pre-peer reviewed version of the following article: Synthesis, In Silico Studies, Antiprotozoal and Cytotoxic Activities of Quinoline‐Biphenyl Hybrids, which has been published in final form at https://doi.org/10.1002/slct.201903835.
Carda, Miguel +6 more
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Heterogeneity of G6PD deficiency prevalence in Mozambique: a school-based cross-sectional survey in three different regions [PDF]
, 2017 Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked hereditary enzymatic abnormality that affects more than 400 million people worldwide.
Aide, Pedro Carlos Paulino +11 more
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A first example of cobalt-catalyzed remote C-H functionalization of 8-aminoquinolines operating through a single electron transfer mechanism [PDF]
, 2016 The development of new C[BOND]H functionalization protocols based on inexpensive cobalt catalysts is currently attracting significant interest. Functionalized 8-aminoquinoline compounds are high-potential building blocks in organic chemistry and ...
Ackermann +49 more
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Recent developments in 8-aminoquinoline antimalarials [PDF]
, 1984 Malaria is an old scourge of mankind and mention of the disease is found in ancient writings in India, Egypt and China [1]. The clinical symptoms of this disease were described by Hippocrates 400 years before the Christian era [1]. Human population affected by malaria is alarmingly large in tropical regions although in the past the disease was also ...
B K, Bhat, M, Seth, A P, Bhaduri
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Wide range of G6PD activities found among ethnic groups of the Chittagong Hill Tracts, Bangladesh.
PLoS Neglected Tropical Diseases, 2020 The proportion of Plasmodium vivax malaria among all malarias is increasing worldwide. Treatment with 8-aminoquinolines remain the only radical cure.
Benedikt Ley +12 more
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Cu(II) and Fe(III) complexes of sulphadoxine mixed with pyramethamine: Synthesis, characterization, antimicrobial and toxicology study [PDF]
, 2012 Two new mixed ligands metal complexes of sulphadoxine and pyramethamine were prepared by using CuCl2.6H2O and FeCl3.6H2O. The complexes were characterized by elemental analysis, melting point determination, molar conductivity, metal content analysis (AAS)
Adekoya, J. A. +5 more
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8-Aminoquinoline Therapy for Latent Malaria [PDF]
Clinical Microbiology Reviews, 2019 The technical genesis and practice of 8-aminoquinoline therapy of latent malaria offer singular scientific, clinical, and public health insights. The 8-aminoquinolines brought revolutionary scientific discoveries, dogmatic practices, benign neglect, and, finally, enduring promise against endemic malaria.
openaire +2 more sources