Results 31 to 40 of about 4,015 (203)
Life Science Alliance, 2022 Infusions from two Artemisia species, one containing artemisinin, the other not, equally inhibit pre-erythrocytic and erythrocytic stages of different Plasmodium species, including two relapsing species.
Kutub Ashraf +18 more
doaj +1 more source
Antimalarial and antimicrobial activities of 8-aminoquinoline-uracils metal complexes [PDF]
, 2016 8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities. This study investigated the potency of 8AQ-5-substituted (iodo and nitro) uracils metal (Mn, Cu, Ni) complexes (1-6) as antimalarial and ...
Kunwittaya, Sarun +6 more
core +1 more source
A Guide to Directing Group Removal: 8‐Aminoquinoline
Chemistry – A European Journal, 2021 AbstractThe use of directing groups allows high levels of selectivity to be achieved in transition metal‐catalyzed transformations. Efficient removal of these auxiliaries after successful functionalization, however, can be very challenging. This review provides a critical overview of strategies used for removal of Daugulis’ 8‐aminoquinoline (2005–2020),
Liam S. Fitzgerald, Miriam L. O'Duill
openaire +2 more sources
Strategies for Understanding and Reducing the Plasmodium vivax and Plasmodium ovale Hypnozoite Reservoir in Papua New Guinean Children: A Randomised Placebo-Controlled Trial and Mathematical Model [PDF]
, 2015 The undetectable hypnozoite reservoir for relapsing Plasmodium vivax and P. ovale malarias presents a major challenge for malaria control and elimination in endemic countries.
Bassat, Quique +19 more
core +11 more sources
Malaria Journal, 2018 Background The study aimed to gain first data on the prevalence of G6PD enzyme deficiency measured by spectrophotometry and associated genetic variants in Jimma and surroundings, Ethiopia.
Nora Kießling +9 more
doaj +1 more source
G6PD Variants and Haemolytic Sensitivity to Primaquine and Other Drugs
Frontiers in Pharmacology, 2021 Restrictions on the cultivation and ingestion of fava beans were first reported as early as the fifth century BC. Not until the late 19th century were clinical descriptions of fava-induced disease reported and soon after characterised as “favism” in the ...
Germana Bancone +3 more
doaj +1 more source
Implications of current therapeutic restrictions for primaquine and tafenoquine in the radical cure of vivax malaria. [PDF]
PLoS Neglected Tropical Diseases, 2018 The 8-aminoquinoline antimalarials, the only drugs which prevent relapse of vivax and ovale malaria (radical cure), cause dose-dependent oxidant haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Patients with
James Watson +5 more
doaj +1 more source
Scientific Reports, 2022 With its strong effect on vector-borne diseases, and insecticidal effect on mosquito vectors of malaria, inhibition of sporogonic and blood-stage development of Plasmodium falciparum, as well as in vitro and in vivo impairment of the P.
Lovepreet Singh +4 more
doaj +1 more source
Malaria Journal, 2020 Background Trials to assess the efficacy of the radical cure of Plasmodium vivax malaria with 8-aminoquinolines require that most post-treatment relapses are identified, but there is no consensus on the optimal duration of follow-up in either symptomatic
Koukeo Phommasone +18 more
doaj +1 more source
Peptidomimetic and Organometallic Derivatives of Primaquine Active against Leishmania infantum [PDF]
, 2012 The current treatment of visceral leishmaniasis is made difficult by the low efficacy, elevated costs, low bioavailability, and high toxicity of many of the available drugs.
Ana Tomas +6 more
core +1 more source