Results 41 to 50 of about 4,015 (203)

Scalable Preparation and Differential Pharmacologic and Toxicologic Profiles of Primaquine Enantiomers [PDF]

, 2016
Hematotoxicity in individuals genetically deficient in glucose-6-phosphate dehydrogenase (G6PD) activity is the major limitation of primaquine (PQ), the only antimalarial drug in clinical use for treatment of relapsing Plasmodium vivax malaria.
Bandara Herath, H. M. T., Baresel, Paul, Bartlett, Marilyn S., Dhammika Nanayakkara, N. P., Fronczek, Frank R., Gettayacamin, Montip, McChesney, James D., Melendez, Victor, Ohrt, Colin, Reichard, Gregory A., Rochford, Rosemary, Sahu, Rajnish, Tekwani, Babu L., Tungtaeng, Anchalee, Van Gessel, Yvonne, Walker, Larry A., Wickham, Kristina S.   +16 more
core   +1 more source

Blocking Plasmodium falciparum Malaria Transmission with Drugs: The Gametocytocidal and Sporontocidal Properties of Current and Prospective Antimalarials

Pharmaceuticals, 2010
Drugs that kill or inhibit the sexual stages of Plasmodium could potentially amplify or synergize the impact of other interventions by blocking transmission to mosquitoes.
Anthony E. Kiszewski
doaj   +1 more source

In silico modeling of tetraoxane-8-aminoquinoline hybrids active against Plasmodium falciparum

Beni-Suef University Journal of Basic and Applied Sciences, 2020
Background Quantitative structure-activity relationships (QSAR) is a technique that is used to produce a model that connects biological activities of compounds to their chemical structures, and molecular docking is a technique that reveals the binding ...
Aliyu Wappah Mahmud, Gideon Adamu Shallangwa, Adamu Uzairu   +2 more
doaj   +1 more source

The blood schizonticidal activity of tafenoquine makes an essential contribution to its prophylactic efficacy in nonimmune subjects at the intended dose (200 mg)

Malaria Journal, 2017
Tafenoquine (TQ) is an 8-aminoquinoline anti-malarial being developed for malaria prophylaxis. It has been generally assumed that TQ, administered prophylactically, acts primarily on the developing exoerythrocytic stages of malaria parasites (causal ...
Geoffrey Dow, Bryan Smith
doaj   +1 more source

A pharmacokinetic–pharmacodynamic model for chemoprotective agents against malaria

CPT: Pharmacometrics & Systems Pharmacology, 2023
Chemoprophylactics are a vital tool in the fight against malaria. They can be used to protect populations at risk, such as children younger than the age of 5 in areas of seasonal malaria transmission or pregnant women.
Mohammed H. Cherkaoui‐Rbati, Nicole Andenmatten, Lydia Burgert, Oluwaseun F. Egbelowo, Rolf Fendel, Chiara Fornari, Michael Gabel, John Ward, Jörg J. Möhrle, Nathalie Gobeau   +9 more
doaj   +1 more source

Haemolysis in G6PD Heterozygous Females Treated with Primaquine for Plasmodium vivax Malaria: A Nested Cohort in a Trial of Radical Curative Regimens.

PLoS Medicine, 2017
BackgroundRadical cure of Plasmodium vivax malaria with 8-aminoquinolines (primaquine or tafenoquine) is complicated by haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Cindy S Chu, Germana Bancone, Kerryn A Moore, Htun Htun Win, Niramon Thitipanawan, Christina Po, Nongnud Chowwiwat, Rattanaporn Raksapraidee, Pornpimon Wilairisak, Aung Pyae Phyo, Lily Keereecharoen, Stéphane Proux, Prakaykaew Charunwatthana, François Nosten, Nicholas J White   +14 more
doaj   +1 more source

Optimizing G6PD testing for Plasmodium vivax case management and beyond: why sex, counseling, and community engagement matter [version 2; peer review: 2 approved]

Wellcome Open Research, 2020
Safe access to the most effective treatment options for Plasmodium vivax malaria are limited by the absence of accurate point-of-care testing to detect glucose-6-phosphate dehydrogenase (G6PD) deficiency, the most common human genetic disorder.
Cindy S Chu, Germana Bancone, Maureen Kelley, Nicole Advani, Gonzalo J Domingo, Eva M Cutiongo-de la Paz, Nicole van der Merwe, Jessica Cohen, Emily Gerth-Guyette   +8 more
doaj   +1 more source

Genome‐Guided Discovery of Antimalarial 4‐Amino‐2,4‐Pentadienoate‐Containing Cyclolipodepsipeptides

Angewandte Chemie International Edition, EarlyView.
Halogenated and glycosylated 4‐amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) exhibit potent antiplasmodial activity (IC50 = 25–161 nM) against drug‐sensitive and resistant Plasmodium falciparum strains. ABSTRACT 4‐Amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) represent a structurally distinctive family of ...
Hartono Candra, Xue‐Jiao Wang, Ka Diam Go, Li Feng, Miaomiao Cai, Guang‐Lei Ma, Clarissa Widyantoro, Lik Tong Tan, Zbynek Bozdech, Zhe Wang, Zhao‐Xun Liang   +10 more
wiley   +1 more source

Validation of the quantitative point-of-care CareStart biosensor for assessment of G6PD activity in venous blood. [PDF]

PLoS ONE, 2018
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy in the human population affecting an estimated 8% of the world population, especially those living in areas of past and present malaria endemicity.
Germana Bancone, Gornpan Gornsawun, Cindy S Chu, Pen Porn, Sampa Pal, Pooja Bansil, Gonzalo J Domingo, Francois Nosten   +7 more
doaj   +1 more source

Real-life implementation of a G6PD deficiency screening qualitative test into routine vivax malaria diagnostic units in the Brazilian Amazon (SAFEPRIM study).

PLoS Neglected Tropical Diseases, 2021
BackgroundGlucose-6-phosphate dehydrogenase (G6PD) deficiency greatly hinders Plasmodium vivax malaria radical cure and further elimination due to 8-aminoquinolines-associated hemolysis.
Jose Diego Brito-Sousa, Felipe Murta, Sheila Vitor-Silva, Vanderson S Sampaio, Maxwell O Mendes, Marcelo A M Brito, Talita S B Batista, Alicia P C Santos, Leonardo L G Marques, Laila R A Barbosa, Marly M Melo, Djane C Baia-da-Silva, Alexandre V Silva-Neto, Thalie C Santos, Brenda K A Souza, Erick F G Figueiredo, Emanuelle L Silva, Sheila Rodovalho, Theresa H Nakagawa, Ana Ruth Arcanjo, André M Siqueira, Gisely C Melo, Judith Recht, Gonzalo J Domingo, Quique Bassat, Germana Bancone, Wuelton M Monteiro, Marcus V G Lacerda   +27 more
doaj   +1 more source