Results 51 to 60 of about 4,015 (203)

Anti-pneumoscystis carinni activitiy of primaquine imidazolidin-4-ones [PDF]

, 2006
Pneumocystis pneumonia (PCP) is one of the most frequent causes of mortality among HIV-infected patients. Primaquine (PQ) is an antimalarial 8-aminoquinoline effective against PCP when given in combination with clindamycin.
Araújo, Maria João, Azevedo, Joana, Collins, Margaret S., Cushion, Melanie T., Ferraz, Ricardo, Gomes, Paula, Moreira, Rui, Vale, Nuno   +7 more
core  

Changing antimalarial drug resistance patterns identified by surveillance at three sites in Uganda. [PDF]

, 2016
: We assessed Plasmodium falciparum drug resistance markers in parasites collected in 2012, 2013, and 2015 at 3 sites in Uganda. The prevalence and frequency of parasites with mutations in putative transporters previously associated with resistance to ...
Asua, V, Conrad, M, Dorsey, G, Greenhouse, B, Kamya, MR, Nankabirwa, J, Nsobya, SL, Rosenthal, PJ, Ruhamyankaka, E, Staedke, SG, Taylor, A, Tukwasibwe, S, Tumwebaze, P, Walakira, A, Yeka, A   +14 more
core   +2 more sources

SYNTHESIS OF 8-AMINOQUINOLINES. PART VII

, 1957
Synthesis of 7-chioro-2-methyl-8-amino-4-(4’-hydroxy-3'-diethylaminomethyl)-anilinoquinaldine has been described.
ACHINTYA K. SEN, U. P. BASU
openaire   +1 more source

Regiodivergent C3 and C4 Amination of Quinolines via Radical and Ionic Pathways

Angewandte Chemie International Edition, EarlyView.
A regiodivergent strategy converts a single N‐aminoquinolinium precursor into either C3‐ or C4‐aminated quinolines. Nucleophile‐induced dearomatization diverges into light‐driven N‐centered radical capture (C3) or base‐promoted SNAr (C4), enabling rapid assembly of aminoquinoline libraries and late‐stage diversification.
Ye‐Eun Kim, Jieun Kim, Juyeon Lee, Sungwoo Hong   +3 more
wiley   +1 more source

Optimizing G6PD testing for Plasmodium vivax case management: why sex, counseling, and community engagement matter [version 1; peer review: 2 approved]

Wellcome Open Research, 2020
Safe access to the most effective treatment options for Plasmodium vivax malaria are limited by the absence of accurate point-of-care testing to detect glucose-6-phosphate dehydrogenase (G6PD) deficiency, the most common human genetic disorder.
Cindy S Chu, Germana Bancone, Maureen Kelley, Nicole Advani, Gonzalo J Domingo, Eva M Cutiongo-de la Paz, Nicole van der Merwe, Jessica Cohen, Emily Gerth-Guyette   +8 more
doaj   +1 more source

First evaluation of glucose-6-phosphate dehydrogenase (G6PD) deficiency in vivax malaria endemic regions in the Republic of Korea. [PDF]

PLoS ONE, 2014
BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect and affects more than 400 million people worldwide.
Youn-Kyoung Goo, So-Young Ji, Hyun-Il Shin, Jun-Hye Moon, Shin-Hyung Cho, Won-Ja Lee, Jung-Yeon Kim   +6 more
doaj   +1 more source

Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview

Chemistry – A European Journal, EarlyView.
The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati, Claudio Trapella, Vinicio Zanirato, Virginia Cristofori, Anna Fantinati   +4 more
wiley   +1 more source

Prevalence of glucose 6-phosphate dehydrogenase deficiency in highly malaria-endemic municipalities in the Brazilian Amazon: A region-wide screening study

The Lancet Regional Health. Americas, 2022
Summary: Background: Difficulties associated with the assessment of glucose-6-phosphate dehydrogenase deficiency (G6PDd), particularly in remote areas, hinders the safe use of 8-aminoquinolines such as primaquine (PQ) and tafenoquine against Plasmodium ...
Joabi Rocha Nascimento, Jose Diego Brito-Sousa, Anne Cristine Gomes Almeida, Marly M Melo, Monica Regina Farias Costa, Laila Rowena Albuquerque Barbosa, Reinaldo Nery Ramos, Alexandre Vilhena Silva-Neto, Patricia Carvalho da Silva Balieiro, Erick Frota Gomes Figueiredo, Emanuelle Lira Silva, Djane Clarys Baia-da-Silva, Quique Bassat, Gustavo Romero, Gisely Cardoso Melo, Vanderson Souza Sampaio, Marcus Lacerda, Wuelton Monteiro   +17 more
doaj   +1 more source

Chan–Lam Cross‐Coupling With Alkylboron Reagents: From Transmetallation to Radical Pathways

European Journal of Organic Chemistry, EarlyView.
Alkylative Chan–Lam coupling overcomes intrinsic transmetallation limitations of alkylboron reagents by engaging radical pathways. Recent advances reveal how radical and radical–polar crossover mechanisms enable mild C(sp3)—heteroatom bond formation. This minireview highlights key mechanistic insights and emerging strategies that transform alkylboron ...
Nicolas G.‐Simonian, Andrea Serafino, Luc Neuville, Géraldine Masson   +3 more
wiley   +1 more source

Safety, tolerability, and efficacy of high versus low-dose, short versus long-course daily primaquine for the radical cure of uncomplicated Plasmodium vivax malaria in children under 15 years of age: an open-label, non-inferiority, randomized controlled trial (CHILDPRIM)

Malaria Journal
Background Primaquine (PQ) is widely used to prevent Plasmodium vivax relapses. However, the most efficacious and safest dose is unknown, particularly in children.
Ana Luisa O. Pacheco, Aretha G. Omena, Djane C. Baía-da-Silva, Tyane A. P. Jardim, Debora C. B. Silva, Adriana P. B. Lopes, Laila R. A. Barbosa, Ingrid G. Souza, Renata F. Araujo, Luis O. S. Nogueira, Suianne C. N. Vale, Gisely C. Melo, Jady S. M. Cordeiro, Quique Bassat, Vanderson S. Sampaio, Valéria D. S. Lima, Flor E. Martinez-Espinosa, Maria Paula G. Mourão, Wuelton M. Monteiro, Maria Graças C. Alecrim, Jose Diego Brito-Sousa, Marcus V. G. Lacerda   +21 more
doaj   +1 more source