Results 61 to 70 of about 4,015 (203)

Assessment of the drugability of initial malaria infection through miniaturized sporozoite assays and high-throughput screening [PDF]

, 2023
The sporozoite stages of malaria parasites are the primary cause of infection of the vertebrate host and are targeted by (experimental) vaccines. Yet, little is known about their susceptibility to chemical intervention. Phenotypic high-throughput screens
Bolscher, Judith M, Campo, Brice, Chen, Emily, de Bruijni, Marloes, Dechering, Koen J, Gray, David, Kiczun, Michael, Koolen, Karin J M, Miglianico, Marie, Rajagopal, Deeya S, Sauerwein, Robert W, Vos, Martijn W   +11 more
core   +2 more sources

A Sustainable Borrowing Hydrogen Strategy in Natural Deep Eutectic Solvents for the N‐Alkylation of Amines From Alcohols

European Journal of Organic Chemistry, EarlyView.
A sustainable, ligand‐free Pd‐catalyzed borrowing hydrogen protocol in a biodegradable hydrophobic natural deep eutectic solvent (NADES) (thymol/DL‐menthol) enables the N‐alkylation of primary amines with benzylic alcohols under mild, aerobic conditions, allowing efficient reuse of both catalyst and solvent for seven consecutive cycles. The hydrophobic
Maryam Saeb, Maristella Simone, Luciana Cicco, Paola Vitale, Filippo Maria Perna, Vito Capriati   +5 more
wiley   +1 more source

Syntheses, neural protective activities, and inhibition of glycogen synthase kinase-3beta of substituted quinolines. [PDF]

, 2014
A new series of fifteen 5-, 6-, and 8-appended 4-methylquinolines were synthesized and evaluated for their neural protective activities. Selected compounds were further examined for their inhibition of glycogen synthase kinase-3β (GSK-3β) and protein ...
Erenler, Ramazan, Hua, Duy H., Jin, Lee-Way, Li, Jun, Lu, Lu, Maezawa, Izumi, Nguyen, James, Nguyen, Thi D.T., Ranjan, Alok, Srivastava, Sanjay K., Swisher, Luxi Zhang, Weerasekara, Sahani   +11 more
core   +1 more source

Photochrome That Was Not: 2-Hydroxynaphtylidene-(8-aminoquinoline)

The Journal of Physical Chemistry A, 2011
We report the results of quantum-chemical calculations, which show that the keto form of 2-hydroxynaphtylidene-(8-aminoquinoline) (HNAQ) is slightly more stable than the enol form both in the ground and first excited ππ* electronic states. The barrier for proton transfer between the enol and the ketone in the ground state is ca.
Zgierski, Marek Z., Lim, Edward C.
openaire   +3 more sources

Tomato Spotted Wilt Virus Reprogrammes Host Glycolysis to Facilitate Proliferation by a Phase‐Separated Co‐Aggregate of Nucleocapsid Protein and Phosphoglycerate Kinase

Plant Biotechnology Journal, EarlyView.
ABSTRACT Efficient viral proliferation within the host is a critical step in pathogenicity and requires adenosine triphosphate (ATP). The replication, movement and immune evasion of many plant viruses within their hosts are associated with phase separation (PS)‐derived aggregates formed by viral components.
Guangcheng Zu, Zhifu Xing, Jiao Li, Tangbing Yang, Huan Wu, Qiangsheng Ge, Yanju Wang, Baoan Song, Runjiang Song   +8 more
wiley   +1 more source

Vivax malaria in pregnancy and lactation: a long way to health equity

Malaria Journal, 2020
Background The Sustainable Development Goals (SDG) call for increased gender equity and reduction in malaria-related mortality and morbidity. Plasmodium vivax infections in pregnancy are associated with maternal anaemia and increased adverse perinatal ...
Tobias Brummaier, Mary Ellen Gilder, Gornpan Gornsawun, Cindy S. Chu, Germana Bancone, Mupawjay Pimanpanarak, Kesinee Chotivanich, François Nosten, Rose McGready   +8 more
doaj   +1 more source

Copper‐ and Silver‐Catalyzed Reactions of Active Methylene Isocyanides: Facile Access to Highly Substituted Five‐ and Six‐Membered Heterocycles

Chemistry – A European Journal, Volume 32, Issue 13, 1 April 2026.
This review summarizes recent advances in copper‐ and silver‐catalyzed reactions of active methylene isocyanides for the synthesis of highly substituted five‐ and six‐membered heterocycles. Emphasis is placed on [3+n] cycloadditions, annulations, and asymmetric strategies, highlighting current limitations and future opportunities in heterocycle ...
Jimil George, Kyungsoo Oh
wiley   +1 more source

: who cares? [PDF]

, 2008
More attention is being focused on malaria today than any time since the world's last efforts to achieve eradication over 40 years ago. The global community is now discussing strategies aimed at dramatically reducing malarial disease burden and the ...
Mary R Galinski, John W Barnwell
core   +1 more source

Evaluation of the Diagnostic Accuracy of the Quantitative Point‐of‐Care SD Biosensor Standard G6PD Test for Assessment of G6PD Deficiency in Infectious Diseases

International Journal of Laboratory Hematology, Volume 48, Issue 2, Page 440-446, April 2026.
ABSTRACT Background G6PD deficiency affects about 500 million people worldwide and is prevalent in many malaria‐endemic settings. People with G6PD deficiency are at risk of hemolysis when exposed to certain medications, including 8‐aminoquinoline drugs used to treat Plasmodium vivax malaria.
Flavia Regina Medeiros da Silva, Alexandre Gomes Vizzoni, Daniela Mendes‐de‐Almeida, Joanna Bokel, Raquel de Vasconcellos Carvalhaes de Oliveira, André Machado Siqueira, Yasmine Rangel Vieira, Simone da Costa Cruz Silva   +7 more
wiley   +1 more source

Characterization of G6PD genotypes and phenotypes on the northwestern Thailand-Myanmar border.

PLoS ONE, 2014
Mutations in the glucose-6-phosphate dehydrogenase (G6PD) gene result in red blood cells with increased susceptibility to oxidative damage. Significant haemolysis can be caused by primaquine and other 8-aminoquinoline antimalarials used for the radical ...
Germana Bancone, Cindy S Chu, Raweewan Somsakchaicharoen, Nongnud Chowwiwat, Daniel M Parker, Prakaykaew Charunwatthana, Nicholas J White, François H Nosten   +7 more
doaj   +1 more source